Imperial College London

DrAndreBrown

Faculty of MedicineInstitute of Clinical Sciences

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

5006Hammersmith HospitalHammersmith Campus

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Summary

 

Summary

See out lab website here: tierpsy.com

We explore the molecular mechanisms underlying nervous system function by finding genes and gene networks that affect behaviour.

The goal of behavioural genomics is to understand the mapping between genome variation and behaviour. However, technology for sequencing and perturbing genomes is advancing more rapidly than our ability to assess all of the consequences of genetic perturbation. To help redress the imbalance between measures of genotype and phenotype, we are developing high-throughput imaging platforms to capture complex behavioural sequences and automated algorithms to interpret them.

Motor behaviour is a useful phenotype because it is the principal output of the nervous system and has previously been used to find genes with roles in synaptic transmission, neural development, and many kinds of sensation among other things. The nematode worm C. elegans is a great model for behavioural genomics in part because of its relatively simple and exceptionally well-characterised nervous system. Its locomotion is sufficiently complex to reliably identify subtle differences between mutants yet simple enough to quantify nearly completely. Well-developed reagents for imaging gene expression and neural activity make for a tight loop between hypothesis generating screens and hypothesis testing functional experiments.

Publications

Journals

Miguel-Aliaga I, Hadjieconomou D, King G, et al., 2020, Enteric neurons increase maternal food intake during reproduction, Nature, ISSN:0028-0836

Li Y, Osuma A, Correa E, et al., 2020, Establishment and maintenance of motor neuron identity via temporal modularity in terminal selector function, Elife, Vol:9, ISSN:2050-084X

Newton H, Wang Y-F, Camplese L, et al., 2020, Systemic muscle wasting and coordinated tumour response drive tumourigenesis, Nature Communications, Vol:11, ISSN:2041-1723

Ding SS, Muhle LS, Brown A, et al., 2020, Comparison of solitary and collective foraging strategies of Caenorhabditis elegans in patchy food distributions, Philosophical Transactions of the Royal Society B: Biological Sciences, Vol:375, ISSN:0962-8436

Martineau CN, Brown AEX, Laurent P, 2020, Multidimensional phenotyping predicts lifespan and quantifies health in C. elegans, Plos Computational Biology, Vol:16, ISSN:1553-734X

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