Imperial College London
Alternate

DrAndreBrown

Faculty of Medicine, Institute of Clinical Sciences

Reader in Behavioural Phenomics
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

4.15BLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Javer:2018:10.1098/rstb.2017.0375,
author = {Javer, A and Ripoll-Sanchez, L and Brown, AE},
doi = {10.1098/rstb.2017.0375},
journal = {Philosophical Transactions B: Biological Sciences},
title = {Powerful and interpretable behavioural features for quantitative phenotyping of C. elegans},
url = {http://dx.doi.org/10.1098/rstb.2017.0375},
volume = {373},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Behaviour is a sensitive and integrative readout of nervous system function and therefore an attractive measure for assessing the effects of mutation or drug treatment on animals. Video data provide a rich but high-dimensional representation of behaviour, and so the first step of analysis is often some form of tracking and feature extraction to reduce dimensionality while maintaining relevant information. Modern machine-learning methods are powerful but notoriously difficult to interpret, while handcrafted features are interpretable but do not always perform as well. Here, we report a new set of handcrafted features to compactly quantify Caenorhabditis elegans behaviour. The features are designed to be interpretable but to capture as much of the phenotypic differences between worms as possible. We show that the full feature set is more powerful than a previously defined feature set in classifying mutant strains. We then use a combination of automated and manual feature selection to define a core set of interpretable features that still provides sufficient power to detect behavioural differences between mutant strains and the wild-type. Finally, we apply the new features to detect time-resolved behavioural differences in a series of optogenetic experiments targeting different neural subsets.
AU  - Javer,A
AU  - Ripoll-Sanchez,L
AU  - Brown,AE
DO  - 10.1098/rstb.2017.0375
PY  - 2018///
SN  - 0962-8436
TI  - Powerful and interpretable behavioural features for quantitative phenotyping of C. elegans
T2  - Philosophical Transactions B: Biological Sciences
UR  - http://dx.doi.org/10.1098/rstb.2017.0375
UR  - http://hdl.handle.net/10044/1/63291
VL  - 373
ER  -
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