Imperial College London
Alternate

DrAndreBrown

Faculty of Medicine, Institute of Clinical Sciences

Reader in Behavioural Phenomics
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

4.15BLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Essmann:2020:10.1038/s41467-020-14785-0,
author = {Essmann, CL and Martinez-Martinez, D and Pryor, R and Leung, K-Y and Krishnan, KB and Lui, PP and Greene, NDE and Brown, AEX and Pawar, VM and Srinivasan, MA and Cabreiro, F},
doi = {10.1038/s41467-020-14785-0},
journal = {Nature Communications},
pages = {1--16},
title = {Mechanical properties measured by Atomic Force Microscopy define health biomarkers in ageing C. elegans},
url = {http://dx.doi.org/10.1038/s41467-020-14785-0},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Genetic and environmental factors are key drivers regulating organismal lifespan but how these impact healthspan is less well understood. Techniques capturing biomechanical properties of tissues on a nano-scale level are providing new insights into disease mechanisms. Here, we apply Atomic Force Microscopy (AFM) to quantitatively measure the change in biomechanical properties associated with ageing Caenorhabditis elegans in addition to capturing high-resolution topographical images of cuticle senescence. We show that distinct dietary restriction regimes and genetic pathways that increase lifespan lead to radically different healthspan outcomes. Hence, our data support the view that prolonged lifespan does not always coincide with extended healthspan. Importantly, we identify the insulin signalling pathway in C. elegans and interventions altering bacterial physiology as increasing both lifespan and healthspan. Overall, AFM provides a highly sensitive technique to measure organismal biomechanical fitness and delivers an approach to screen for health-improving conditions, an essential step towards healthy ageing.
AU  - Essmann,CL
AU  - Martinez-Martinez,D
AU  - Pryor,R
AU  - Leung,K-Y
AU  - Krishnan,KB
AU  - Lui,PP
AU  - Greene,NDE
AU  - Brown,AEX
AU  - Pawar,VM
AU  - Srinivasan,MA
AU  - Cabreiro,F
DO  - 10.1038/s41467-020-14785-0
EP  - 16
PY  - 2020///
SN  - 2041-1723
SP  - 1
TI  - Mechanical properties measured by Atomic Force Microscopy define health biomarkers in ageing C. elegans
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/s41467-020-14785-0
UR  - https://www.nature.com/articles/s41467-020-14785-0
UR  - http://hdl.handle.net/10044/1/77395
VL  - 11
ER  -
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