Imperial College London
Alternate

DrAndreBrown

Faculty of Medicine, Institute of Clinical Sciences

Reader in Behavioural Phenomics
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

4.15BLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Schwarz:2015:10.1371/journal.pcbi.1004322,
author = {Schwarz, RF and Branicky, R and Grundy, LJ and Schafer, WR and Brown, AEX},
doi = {10.1371/journal.pcbi.1004322},
journal = {PLOS Computational Biology},
title = {Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion},
url = {http://dx.doi.org/10.1371/journal.pcbi.1004322},
volume = {11},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Locomotion is driven by shape changes coordinated by the nervous system through time;thus, enumerating an animal's complete repertoire of shape transitions would provide abasis for a comprehensive understanding of locomotor behaviour. Here we introduce a discreterepresentation of behaviour in the nematode C. elegans. At each point in time, theworm’s posture is approximated by its closest matching template from a set of 90 posturesand locomotion is represented as sequences of postures. The frequency distribution of posturalsequences is heavy-tailed with a core of frequent behaviours and a much larger set ofrarely used behaviours. Responses to optogenetic and environmental stimuli can be quantifiedas changes in postural syntax: worms show different preferences for differentsequences of postures drawn from the same set of templates. A discrete representation of behaviour will enable the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behaviour.
AU  - Schwarz,RF
AU  - Branicky,R
AU  - Grundy,LJ
AU  - Schafer,WR
AU  - Brown,AEX
DO  - 10.1371/journal.pcbi.1004322
PY  - 2015///
SN  - 1553-734X
TI  - Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion
T2  - PLOS Computational Biology
UR  - http://dx.doi.org/10.1371/journal.pcbi.1004322
UR  - http://hdl.handle.net/10044/1/32428
VL  - 11
ER  -
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