Imperial College London
Alternate

DrAndreBrown

Faculty of Medicine, Institute of Clinical Sciences

Reader in Behavioural Phenomics
 
 
 
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Contact

 

+44 (0)20 3313 8218andre.brown

 
 
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Location

 

4.15BLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Keaveny:2017:1478-3975/aa5ce6,
author = {Keaveny, E and Brown, AE},
doi = {1478-3975/aa5ce6},
journal = {Physical Biology},
title = {Predicting path from undulations for C. elegans using linear and nonlinear resistive force theory},
url = {http://dx.doi.org/10.1088/1478-3975/aa5ce6},
volume = {14},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A basic issuein the physics of behaviouris the mechanical relationship between an animal and its surroundings.  The nematode and model organism C. elegans provides an excellent platform to explore this relationship due to its anatomical simplicity.  Nonetheless,the physics of nematode crawling, in which the worm undulates its body to move on a wet surface, is not completely understoodand the mathematical models often used to describe this phenomenon are empirical.  We confirm that linear resistive force theory, one such empirical model,is effective at predicting a worm’s path from its sequence of body postures for forward crawling, reversing, and turning and for a broad range of different behavioural phenotypes observedin mutant worms.  However, agreement between the predicted and observed path is lost when using this model with recently measured valuesof the drag anisotropy.  A recently proposed nonlinear extensionof the resistive force theory model also provides accurate predictions, but does not resolve the discrepancy between the parameters required to achieve good path prediction and the experimentally measured parameters.  This meansthat while we have good effective models of worm crawling that can be used in applications such as whole-animal simulations and advanced tracking algorithms, there are still unanswered questions about the precise nature of the physical interaction between worms and their most commonly studied laboratory substrate.
AU  - Keaveny,E
AU  - Brown,AE
DO  - 1478-3975/aa5ce6
PY  - 2017///
SN  - 1478-3975
TI  - Predicting path from undulations for C. elegans using linear and nonlinear resistive force theory
T2  - Physical Biology
UR  - http://dx.doi.org/10.1088/1478-3975/aa5ce6
UR  - http://hdl.handle.net/10044/1/44246
VL  - 14
ER  -
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