Imperial College London
Alternate

Emeritus ProfessorAndrewHolmes

Faculty of Natural Sciences, Department of Chemistry

Distinguished Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 9286andrew.holmes Website

 
 
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Assistant

 

Ms Maria Tortelli +44 (0)20 7594 9286

 
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Location

 

Molecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Billington:2004:10.1042/BJ20031284,
author = {Billington, RA and Thuring, JW and Conway, SJ and Packman, L and Holmes, AB and Genazzani, AA},
doi = {10.1042/BJ20031284},
journal = {Biochem J},
pages = {275--280},
title = {Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).},
url = {http://dx.doi.org/10.1042/BJ20031284},
volume = {378},
year = {2004}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The pyridine nucleotide NAADP (nicotinic acid-adenine dinucleotide phosphate) has been shown to act as a Ca2+-releasing intracellular messenger in a wide variety of systems from invertebrates to mammals and has been implicated in a number of cellular processes. NAADP is structurally very similar to its precursor, the endogenous coenzyme NADP and while much is known about the reduced form of NADP, NADPH, it is not known whether NAADP can also exist in a reduced state. Here we report that NAADP can be reduced to NAADPH by endogenous cellular enzymes and that NAADPH is functionally inert at the NAADP receptor. These data suggest that NAADPH could represent a mechanism for rapidly inactivating NAADP in cells.
AU  - Billington,RA
AU  - Thuring,JW
AU  - Conway,SJ
AU  - Packman,L
AU  - Holmes,AB
AU  - Genazzani,AA
DO  - 10.1042/BJ20031284
EP  - 280
PY  - 2004///
SP  - 275
TI  - Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).
T2  - Biochem J
UR  - http://dx.doi.org/10.1042/BJ20031284
UR  - https://www.ncbi.nlm.nih.gov/pubmed/14606955
VL  - 378
ER  -
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