Imperial College London

Dr Andrew Thorley

Faculty of MedicineNational Heart & Lung Institute

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2990andrew.thorley Website

 
 
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Location

 

B140BGuy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

53 results found

Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DEet al., 2017, The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis, ONCOTARGET, Vol: 8, Pages: 48737-48754, ISSN: 1949-2553

JOURNAL ARTICLE

Thorley A, Ogger P, Legorburo-Schofield M, Tetley T, Wollin Let al., 2017, Nintedanib Effectively Inhibits Carbon Nanotube-Induced Fibrotic Responses In Human Alveolar Epithelial Cells, Fibroblasts And Pulmonary Microvascular Endothelial Cells, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Chen S, Goode AE, Skepper JN, Thorley AJ, Seiffert JM, Chung KF, Tetley TD, Shaffer MSP, Ryan MP, Porter AEet al., 2016, Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments, JOURNAL OF MICROSCOPY, Vol: 261, Pages: 157-166, ISSN: 0022-2720

JOURNAL ARTICLE

Ruenraromgsak P, Chen S, Hu S, Melbourne J, Sweeney S, Thorley AJ, Skepper JN, Shaffer MSP, Tetley TD, Porter AEet al., 2016, Translocation of Functionalized Multi-Walled Carbon Nanotubes across Human Pulmonary Alveolar Epithelium: Dominant Role of Epithelial Type 1 Cells, ACS NANO, Vol: 10, Pages: 5070-5085, ISSN: 1936-0851

JOURNAL ARTICLE

Sweeney S, Leo BF, Chen S, Abraham-Thomas N, Thorley AJ, Gow A, Schwander S, Zhang JJ, Shaffer MSP, Chung KF, Ryan MP, Porter AE, Tetley TDet al., 2016, Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 145, Pages: 167-175, ISSN: 0927-7765

JOURNAL ARTICLE

Cryer AM, Ruenraroengsak P, Tetley TD, Thorley AJet al., 2015, SYNTHESIS OF GOLD-BASED NANOMEDICINES TO TREAT NON-SMALL CELL LUNG CANCER, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376

CONFERENCE PAPER

Sweeney S, Berhanu D, Ruenraroengsak P, Thorley AJ, Valsami-Jones E, Tetley TDet al., 2015, Nano-titanium dioxide bioreactivity with human alveolar type-I-like epithelial cells: Investigating crystalline phase as a critical determinant, NANOTOXICOLOGY, Vol: 9, Pages: 482-492, ISSN: 1743-5390

JOURNAL ARTICLE

Chen S, Hu S, Smith EF, Ruenraroengsak P, Thorley AJ, Menzel R, Goode AE, Ryan MP, Tetley TD, Porter AE, Shaffer MSPet al., 2014, Aqueous cationic, anionic and non-ionic multi-walled carbon nanotubes, functionalised with minimal framework damage, for biomedical application, BIOMATERIALS, Vol: 35, Pages: 4729-4738, ISSN: 0142-9612

JOURNAL ARTICLE

Mukherjee D, Royce SG, Sarkar S, Thorley A, Schwander S, Ryan MP, Porter AE, Chung KF, Tetley TD, Zhang J, Georgopoulos PGet al., 2014, Modeling in vitro cellular responses to silver nanoparticles., J Toxicol, Vol: 2014, ISSN: 1687-8191

Engineered nanoparticles (NPs) have been widely demonstrated to induce toxic effects to various cell types. In vitro cell exposure systems have high potential for reliable, high throughput screening of nanoparticle toxicity, allowing focusing on particular pathways while excluding unwanted effects due to other cells or tissue dosimetry. The work presented here involves a detailed biologically based computational model of cellular interactions with NPs; it utilizes measurements performed in human cell culture systems in vitro, to develop a mechanistic mathematical model that can support analysis and prediction of in vivo effects of NPs. The model considers basic cellular mechanisms including proliferation, apoptosis, and production of cytokines in response to NPs. This new model is implemented for macrophages and parameterized using in vitro measurements of changes in cellular viability and mRNA levels of cytokines: TNF, IL-1b, IL-6, IL-8, and IL-10. The model includes in vitro cellular dosimetry due to nanoparticle transport and transformation. Furthermore, the model developed here optimizes the essential cellular parameters based on in vitro measurements, and provides a "stepping stone" for the development of more advanced in vivo models that will incorporate additional cellular and NP interactions.

JOURNAL ARTICLE

Novak P, Shevchuk A, Ruenraroengsak P, Miragoli M, Thorley AJ, Klenerman D, Lab MJ, Tetley TD, Gorelik J, Korchev YEet al., 2014, Imaging Single Nanoparticle Interactions with Human Lung Cells Using Fast Ion Conductance Microscopy, NANO LETTERS, Vol: 14, Pages: 1202-1207, ISSN: 1530-6984

JOURNAL ARTICLE

Sweeney S, Berhanu D, Misra SK, Thorley AJ, Valsami-Jones E, Tetley TDet al., 2014, Multi-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cells, CARBON, Vol: 78, Pages: 26-37, ISSN: 0008-6223

JOURNAL ARTICLE

Thorley AJ, Ruenraroengsak P, Potter TE, Tetley TDet al., 2014, Critical Determinants of Uptake and Trans location of Nanoparticles by the Human Pulmonary Alveolar Epithelium, ACS NANO, Vol: 8, Pages: 11778-11789, ISSN: 1936-0851

JOURNAL ARTICLE

Chen S, Goode AE, Sweeney S, Theodorou IG, Thorley AJ, Ruenraroengsak P, Chang Y, Gow A, Schwander S, Skepper J, Zhang JJ, Shaffer MS, Chung KF, Tetley TD, Ryan MP, Porter AEet al., 2013, Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism, NANOSCALE, Vol: 5, Pages: 9839-9847, ISSN: 2040-3364

JOURNAL ARTICLE

Nestorowa S, Tetley TD, Thorley AJ, 2013, PULMONARY SURFACTANT PROTECTS AGAINST SILVER NANOPARTICLE-INDUCED INFLAMMATION IN THE PERIPHERAL HUMAN LUNG, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A138-A139, ISSN: 0040-6376

CONFERENCE PAPER

Solomon A, Smyth E, Mitha N, Pitchford S, Vydyanath A, Luther PK, Thorley AJ, Tetley TD, Emerson Met al., 2013, Induction of platelet aggregation after a direct physical interaction with diesel exhaust particles, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Vol: 11, Pages: 325-334, ISSN: 1538-7933

JOURNAL ARTICLE

Tetley TD, Thorley AJ, 2013, Health effects, Biochemist, Vol: 35, Pages: 14-20, ISSN: 0954-982X

JOURNAL ARTICLE

Thorley AJ, Tetley TD, 2013, New perspectives in nanomedicine, PHARMACOLOGY & THERAPEUTICS, Vol: 140, Pages: 176-185, ISSN: 0163-7258

JOURNAL ARTICLE

Zambianchi MZ, Tetley TD, Thorley AJ, 2013, ALVEOLAR EPITHELIAL DNA DAMAGE, INFLAMMATION AND ALTERED AUTOPHAGY FOLLOWING EXPOSURE TO SILVER NANOPARTICLES IS EXACERBATED BY VIRAL LIGANDS IN VITRO, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A52-A52, ISSN: 0040-6376

CONFERENCE PAPER

Beverly A, Tetley TD, Thorley AJ, 2012, PRO-FIBROTIC EFFECTS OF MULTI-WALLED CARBON NANOTUBE EXPOSURE ON PRIMARY HUMAN ALVEOLAR TYPE II EPITHELIAL CELLS AND FIBROBLASTS, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A60-A60, ISSN: 0040-6376

CONFERENCE PAPER

Misra SK, Tetley TD, Thorley A, Boccaccini AR, Valsami-Jones Eet al., 2012, Engineered Nanomaterials, Pollutants, Human Health and the Environment: A Risk Based Approach, Pages: 287-318, ISBN: 9780470742617

BOOK CHAPTER

Ruenraroengsak P, Novak P, Berhanu D, Thorley AJ, Valsami-Jones E, Gorelik J, Korchev YE, Tetley TDet al., 2012, Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles, NANOTOXICOLOGY, Vol: 6, Pages: 94-108, ISSN: 1743-5390

JOURNAL ARTICLE

Bolasco G, Tracey-White DC, Tolmachova T, Thorley AJ, Tetley TD, Seabra MC, Hume ANet al., 2011, Loss of Rab27 function results in abnormal lung epithelium structure in mice, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Vol: 300, Pages: C466-C476, ISSN: 0363-6143

JOURNAL ARTICLE

Thorley AJ, Grandolfo D, Lim E, Goldstraw P, Young A, Tetley TDet al., 2011, Innate Immune Responses to Bacterial Ligands in the Peripheral Human Lung - Role of Alveolar Epithelial TLR Expression and Signalling, PLOS ONE, Vol: 6, ISSN: 1932-6203

JOURNAL ARTICLE

Grandolfo D, Thorley AJ, Salmon GP, Tetley TDet al., 2010, Differential Effect Of Toll-like Receptor Activation On Primary Human Alveolar Epithelium And Alveolar Macrophage Mediator Release In Vitro; Synergistic Effect Of Co-culture, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 181, ISSN: 1073-449X

JOURNAL ARTICLE

Maher TM, Evans IC, Bottoms SE, Mercer PF, Thorley AJ, Nicholson AG, Laurent GJ, Tetley TD, Chambers RC, McAnulty RJet al., 2010, Diminished Prostaglandin E-2 Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 182, Pages: 73-82, ISSN: 1073-449X

JOURNAL ARTICLE

Nuseibeh S, Thorley AJ, Tetley TD, 2010, Effect of serum proteins on the cytotoxic and pro-inflammatory response of human alveolar type I epithelial cells to metal oxide nanoparticles, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Ruenraroengsak P, Thorley AJ, Tetley TD, 2010, Induction of oxidative stress and cell death in human alveolar epithelium following nanoparticle exposure depends on surface charge, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Sweeney SS, Ruenraroengsak P, Berhanu D, Valsami-Jones E, Thorley AJ, Tetley TDet al., 2010, Differential reactivity of nano-TiO2 with human lung alveolar epithelium in vitro: importance of physicochemistry, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Thorley AJ, Tetley TD, 2010, Mechanisms of uptake of nano-sized latex beads by human alveolar type I epithelial (ATI) cells, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Koenigshoff M, Howell DCJ, McAnulty RJ, Das A, Thorley AJ, Tetley TD, Eickelberg O, Chambers RCet al., 2009, Pulmonary Epithelium Is a Prominent Source of Proteinase-activated Receptor-1-inducible CCL2 in Pulmonary Fibrosis, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, Pages: 414-425, ISSN: 1073-449X

JOURNAL ARTICLE

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