Imperial College London

Dr Andrew Thorley

Faculty of MedicineNational Heart & Lung Institute

Honorary Lecturer



+44 (0)20 7594 2990andrew.thorley Website




B140BGuy Scadding BuildingRoyal Brompton Campus





Dr Mark Griffiths, Royal Brompton and Harefield Trust, Distribution and translocation of nanoparticles in ex vivo lung perfusion model, 2013

Dr Matthew Hind, Royal Brompton and Harefield Trust, Distribution and translocation of nanoparticles in ex vivo lung perfusion model, 2013

Dr Alexandra Porter, Imperial College London, State of the art imaging of nanoparticle-cell interactions, 2010

Dr Barbara Rothen-Rutishauser, University of Bern, 2009

Professors Parmjit Jat and Michael O'Hare, UCL Ludwig Institute for Cancer Research, 2008

Professor Rachel Chambers, Centre for Respiratory Research, UCL, 2005

Guest Lectures

Nanomedicine for treatment of non-small cell lung cancer, London Centre for Nanotechnology, London, 2015

Antibody targeting in nanomedicine, British Pharmacological Society, London, 2016

Alveolar epithelial–macrophage crosstalk in response to microbial ligands, British Association for Lung Research, University of Sheffield, 2016

Modelling particle uptake in the lung, In Vitro Toxicology Society, Glasgow, 2016

Investigating the potential adverse health effects of artificial turf, SALTEX, Birmingham, 2016

Alveolar cells – State of the art research techniques from the Royal Brompton Hospital and Imperial College London, European Respiratory Society International Congress, London, 2016

Endocytosis pathways and nanomedicines in the human lung, University of Exeter, Institute of Physics, 2016

Innate immunity in the peripheral human lung, University of Ulm, Ulm, Germany, 2016

Modelling particle uptake in the lung, European Respiratory Society, 2016

Genotoxic and inflammatory effects of silver nanoparticles in the lung, NIHR Health Protection Research Unit in Health Impact of Environmental Hazards, 2016

Inhaled engineered nanoparticles – a cause for concern?, Imperial College London, 2013

Engineered nanoparticles as novel vectors for drug delivery, Imperial College London, 2014

Health effects of inhaled nanoparticles, MRC-HPA Centre for Public Health, 2012

How might engineered nanomaterials harm your lungs (and other parts of you)?, Occupational lung disease - Keeping up to date, NHLI, Imperial College, 2013

Engineered nanoparticles and the pulmonary innate immune response, University of Southampton, 2013

Nanomedicine - Solving or creating problems?, MRC Toxicology Unit, University of Leicester, 2012

Nanoparticles; Holy Grail or wholly disaster?, British Thoracic Society, 2012

Uptake of nanoparticles by the human alveolar epithelium, European Science Federation workshop on human nanotoxicology and nanomedicine, 2011

Dendritic cells and the respiratory epithelium, EuroSciCon, 2011

Factors Affecting Uptake and Toxicity of Nanoparticles in the Peripheral Human Lung, Rusnanotech, Moscow, 2010

Alveolar epithelial responses to infection and inhaled toxicants, University of Southampton, 2010

Generation of immortalised human alveolar type-I epithelial cells, Turkish Thoracic Society, University of Gaziantep, 2010

How do the physicochemical properties of nanoparticles affect their uptake by the respiratory epithelium?, HSL Headquarters, Buxton, 2010

Mechanisms of uptake of nano-sized latex beads by human alveolar type I epithelial cells, DEFRA, 2009

A study to identify physicochemical factors contolling the capacity of nanoparticles to penetrate cells of the respiratory epithelium, Advisory Committee for Hazardous Substances, DEFRA, DEFRA Headquarters, Whitehall, 2008

Research Staff


Research Student Supervision

Ogger,P, The effect of the triple tyrosine kinase inhibitor nintedanib on carbon nanotube-induced pulmonary fibrosis

Maksoudian,C, Development of antibody-labelled nanoparticles for imaging and treatment of lung cancers

Vaitkute,A, CNT-induced pulmonary fibrosis

Wong,D, Metabolomic changes induced by nanomedicines in development for the treatment of non-small cell lung cancer

Dean,L, Interaction of inhaled nanomaterials at the air-liquid interface of the respiratory unit using complex in vitro models of primary human lung cells

Ong,W, Design of nanomedicines to target GRP and V1A receptors expressed in small cell lung cancer

Cryer,A, Synthesis of cisplatin and pemetrexed-conjugated gold nanoparticles for the treatment of non-small cell lung cancer

Schofield Legorburo,M, The effect of nintedanib on carbon nanotube-induced proliferation and fibrotic responses of primary human alveolar epithelial cells, pulmonary fibroblasts and microvascular endothelial cells

Abraham Thomas,N, The effect of pulmonary surfactant on the bioreactivity of silver nanoparticles in alveolar epithelial cells

Rampuri,R, Do engineered nanofibres induce pro-fibrotic responses in human alveolar epithelial cells and fibroblasts?

Nestorowa,S, The effect of surfactant on the bioreactivity of silver nanoparticles

Simmonds,J, Role of alveolar macrophage-epithelial interactions in nanoparticle-induced toxicity and inflammation

Baker,W, Risk assessment for manufactured nanoparticles used in consumer products

Jeyapalan,S, Assessment of nanoparticle toxicity using metabonomic profiling

Zambianchi,M, A study of the effect of engineered nanoparticles on the innate immune response of the human alveolar epithelium to bacterial and viral infection

Grandolfo,D, Effect of cigarette smoke and Toll-like receptor activation on alveolar inflammation

Sweeney,S, Differential reactivity of engineered nanomaterials with human alveolar epithelium and macrophages in vitro: importance of physicochemistry

Smith,E, Investigation of the effects, and cellular translocation, of inhaled nano-sized environmental and manufactured materials at the blood-gas barrier of the lung: implications for cardiovascular reactivity

Nestorowa,S, Effect of pulmonary surfactant on the bioreactivity of silver nanoparticles in the peripheral human lung

Rampuri,R, Effect of surfactant on the pro-fibrotic response of human alveolar epithelial cells and fibroblasts to carbon nanotubes

Beverly,A, Do engineered nanoparticles induce a fibrotic response in the human peripheral lung?

Evans,D, Do engineered nanoparticles induce a pro-fibrotic response in the alveolar unit?

Evans,GL, Effect of engineered nanoparticles on the response of the alveolar epithelium to infection

Mei,E, Effect of cigarette smoke and TLR ligand-induced cytokine release by human lung alveolar epithelial cells on dendritic cell migration and maturation