Imperial College London


Faculty of MedicineDepartment of Medicine

Chair in Addiction Biology



+44 (0)20 7594 8682anne.lingford-hughes Website




Ms Nicole Hickey +44 (0)20 3313 4161




Burlington DanesHammersmith Campus





Professor Anne Lingford-Hughes is Head, Centre for Psychiatry and Professor of Addiction Biology at Imperial College London. She is also a Consultant Psychiatrist with a particular interest in pharmacological treatments of alcohol problems and other substance addictions at Central North West London NHS Foundation Trust. Her research has focused on using neuroimaging and neuropharmacological challenges to characterize the neurobiology of addiction. In particular she has used positron emission tomography (PET) and MR to characterize the dopamine (DRD2, DRD3), opioid (mu), GABA-benzodiazepine (a5 subtype), GABA-B, NK1 receptor systems in a range of substance addictions including alcoholism, cocaine and opiate dependence as well disordered gambling. More recently she has been exploring neuroinflammatory processes and amyloid deposition in alcoholism. The aim of her research programme is to better understand neurobiology underpinning these disorders to improve treatment.

If you are interested in finding out more about our studies into alcoholism and participating if you are abstinent and well, please email for more information.

Professor Anne Lingford-Hughes leads the MRC Addiction Research Clinical Training Programme (MARC) with Prof Colin Drummond, IOPPN, KCL and Prof Matt Hickman, University of Bristol. For events and opportunities associated with MARC see Please contact us if you are a clinician interested in exploring the possibility of conducting a PhD in the area of addiction to develop your career in this vital clinical area.

Prof Lingford-Hughes is past Hon. General Secretary of the British Association for Psychopharmacology. She co-developed and wrote their guidelines about the pharmacological management of substance misuse and addiction and comorbidity with psychiatric disorders. She has also contributed to NICE guidance regarding pharmacotherapy of opiate detoxification and alcohol misuse and dependence.

She is currently Chair of the Academic Faculty of RCPsych.

She graduated in medicine from Oxford University, completed her PhD at Cambridge University, and trained in psychiatry at The Bethlem and Maudsley Hospitals and Institute of Psychiatry.



Palmer E, Tyacke R, Sastre M, et al., 2019, Alcohol Hangover: Underlying Biochemical, Inflammatory and Neurochemical Mechanisms., Alcohol Alcohol

De Beaurepaire R, Sinclair JMA, Heydtmann M, et al., 2019, The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective, Frontiers in Psychiatry, Vol:9, ISSN:1664-0640

Lingford-Hughes A, Watson S, Young A, 2019, Treatment-resistant mood disorders: towards better understanding and treatment, British Journal of Psychiatry, Vol:214, ISSN:0007-1250, Pages:A3-A5

Durant CF, Paterson LM, Turton S, et al., 2018, Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures, Frontiers in Psychiatry, Vol:9, ISSN:1664-0640

Agabio R, Sinclair JMA, Addolorato G, et al., 2018, Baclofen for the treatment of alcohol use disorder: the Cagliari Statement, Lancet Psychiatry, Vol:5, ISSN:2215-0374, Pages:957-960

More Publications