Imperial College London

ProfessorAnneLingford-Hughes

Faculty of MedicineDepartment of Medicine

Chair in Addiction Biology
 
 
 
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Contact

 

+44 (0)20 7594 8682anne.lingford-hughes Website

 
 
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Assistant

 

Mrs Gearoidin Beazley +44 (0)20 7594 7047

 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

238 results found

Taylor EM, Murphy A, Boyapati V, Ersche KD, Flechais R, Kuchibatla S, McGonigle J, Metastasio A, Nestor L, Orban C, Passetti F, Paterson L, Smith D, Suckling J, Tait R, Lingford-Hughes AR, Robbins TW, Nutt DJ, Deakin JFW, Elliott Ret al., 2016, Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach, PSYCHOPHARMACOLOGY, Vol: 233, Pages: 1487-1499, ISSN: 0033-3158

JOURNAL ARTICLE

Turton S, Lingford-Hughes A, 2016, Neurobiology and principles of addiction and tolerance, Medicine (United Kingdom), Vol: 44, Pages: 693-696, ISSN: 1357-3039

© 2016 Elsevier Ltd Substances of abuse dysregulate key brain systems involved in motivation, reward, decision-making and memory. As drug use evolves into a compulsive addiction, there are adaptations in these systems, mediated by a number of different neurotransmitters. The mesolimbic dopaminergic pathway plays a central role in the pleasurable and positive reinforcing effects of drugs. As an individual becomes addicted, there is a shift away from this positive reinforcement to the compulsive, habitual drug-seeking behaviours driven, for example, by cravings or withdrawal symptoms. Although the potential for addiction is common with all drugs of abuse, the underlying mechanisms, neurotransmission systems and adaptations vary between drugs. This review focuses on the neurobiology of addiction and tolerance for alcohol, benzodiazepines, opioids and stimulants.

JOURNAL ARTICLE

Turton S, Myers J, Mick I, Rabiner E, Gunn R, Nutt D, Lingford-Hughes Aet al., 2016, Alcohol dependent patients have blunted endogenous opioid release measured using [C-11] carfentanil PET and dexamphetamine challenge, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S676-S677, ISSN: 0924-977X

CONFERENCE PAPER

Crawford MJ, Sanatinia R, Barrett B, Byford S, Dean M, Green J, Jones R, Leurent B, Sweeting MJ, Touquet R, Greene L, Tyrer P, Ward H, Lingford-Hughes Aet al., 2015, The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial, SEXUALLY TRANSMITTED INFECTIONS, Vol: 91, Pages: 37-43, ISSN: 1368-4973

JOURNAL ARTICLE

Lingford-Hughes A, 2015, AN FMRI STUDY OF NALMEFENE ON ALCOHOL EFFECTS IN REWARD ANTICIPATION IN ALCOHOL DEPENDENCE, ALCOHOL AND ALCOHOLISM, Vol: 50, ISSN: 0735-0414

JOURNAL ARTICLE

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