238 results found
Taylor EM, Murphy A, Boyapati V, et al., 2016, Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach, PSYCHOPHARMACOLOGY, Vol: 233, Pages: 1487-1499, ISSN: 0033-3158
Turton S, Lingford-Hughes A, 2016, Neurobiology and principles of addiction and tolerance, Medicine (United Kingdom), Vol: 44, Pages: 693-696, ISSN: 1357-3039
© 2016 Elsevier Ltd Substances of abuse dysregulate key brain systems involved in motivation, reward, decision-making and memory. As drug use evolves into a compulsive addiction, there are adaptations in these systems, mediated by a number of different neurotransmitters. The mesolimbic dopaminergic pathway plays a central role in the pleasurable and positive reinforcing effects of drugs. As an individual becomes addicted, there is a shift away from this positive reinforcement to the compulsive, habitual drug-seeking behaviours driven, for example, by cravings or withdrawal symptoms. Although the potential for addiction is common with all drugs of abuse, the underlying mechanisms, neurotransmission systems and adaptations vary between drugs. This review focuses on the neurobiology of addiction and tolerance for alcohol, benzodiazepines, opioids and stimulants.
Turton S, Myers J, Mick I, et al., 2016, Alcohol dependent patients have blunted endogenous opioid release measured using [C-11] carfentanil PET and dexamphetamine challenge, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S676-S677, ISSN: 0924-977X
Crawford MJ, Sanatinia R, Barrett B, et al., 2015, The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial, SEXUALLY TRANSMITTED INFECTIONS, Vol: 91, Pages: 37-43, ISSN: 1368-4973
Lingford-Hughes A, 2015, AN FMRI STUDY OF NALMEFENE ON ALCOHOL EFFECTS IN REWARD ANTICIPATION IN ALCOHOL DEPENDENCE, ALCOHOL AND ALCOHOLISM, Vol: 50, ISSN: 0735-0414
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