Publications
324 results found
Williams TM, Davies SJC, Taylor LG, et al., 2008, Can personality traits elucidate the relationship between substance dependence and opioid receptor availability?, 21st Congress of the European-College-of-Neuropsychopharmacology, Publisher: ELSEVIER SCIENCE BV, Pages: S536-S536, ISSN: 0924-977X
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- Citations: 2
Hood S, Melichar J, Taylor L, et al., 2008, Noradrenergic function in generalised anxiety disorder (GAD): A single photon emission tomography (SPET) study, 26th Collegium Internationale Neuro-Psychopharmacologicum Congress (CINP), Publisher: CAMBRIDGE UNIV PRESS, Pages: 278-278, ISSN: 1461-1457
Hickman M, Lingford-Hughes A, Bailey C, et al., 2008, Does alcohol increase the risk of overdose death: the need for a translational approach, ADDICTION, Vol: 103, Pages: 1060-1062, ISSN: 0965-2140
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- Citations: 39
Hickman M, Lingford-Hughes A, Bailey C, et al., 2008, Understanding causal pathways: A response to the commentaries, ADDICTION, Vol: 103, Pages: 1067-1068, ISSN: 0965-2140
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- Citations: 1
Daglish MR, Williams TM, Wilson SJ, et al., 2008, Brain dopamine response in human opioid addiction, Br.J.Psychiatry, Vol: 193, Pages: 65-72
BACKGROUND: Drugs of dependence cause dopamine release in the rat striatum. Human neuroimaging studies have shown an increase in dopamine in the equivalent region in response to stimulants and other drugs. AIMS: We tested whether opioids provoke dopamine release and its relationship to the subjective experience. METHOD: In two combined studies 14 heroin addicts on methadone maintenance treatment underwent two positron emission tomography brain scans of the dopamine system using [(11)C]-raclopride following an injection of placebo and either 50 mg intravenous diamorphine or 10 mg subcutaneous hydromorphone in a double-blind, random order design. RESULTS: Both opioids produced marked subjective and physiological effects, but no measurable change in [(11)C]-raclopride binding. CONCLUSIONS: The absence of a dopamine response to opioid agonists contrasts with that found with stimulant drugs and suggests dopamine may not play the same role in addiction to opioids. This questions the role of dopamine in the subjective experience of heroin in opioid addicts
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