Professor Anthony Gordon is the Chair in Anaesthesia and Critical Care at Imperial College and is a Consultant in Intensive Care Medicine based at St Mary's Hospital.
He received his medical degree from St Bartholomew’s Medical School in 1993 and then undertook his postgraduate medical training across the North Thames regions with an additional year spent at The Royal North Shore Hospital in Sydney, Australia. He was awarded the Fellowship of the Royal College of Anaesthetists in 1999 and returned to Barts to obtain his research doctorate examining genetic susceptibility in sepsis.
Having obtained a dual CCST in Anaesthesia and Intensive Care Medicine he was awarded the Intensive Care Society visiting fellowship in 2005 and spent two years in Vancouver at St Paul’s Hospital, University of British Columbia as a post-doctorate fellow. During this time he also worked as the Director of Medical Development of a university spin-out company developing pharmacogenetic tests for use in the ICU.
Prof Gordon returned to the Imperial AHSC in November 2007, and was a recipient of a Clinician Scientist Fellowship award from the National Institute for Health Research (NIHR) and is currently an NIHR Research Professor.
His research is focused on clinical and translational studies in sepsis. Particularly
- He is Chief investigator on two multi-centre trials examining alternatives to catecholamines in septic shock. Early vasopressin use in septic shock and its interaction with corticosteroids (VANISH trial) and also levosimendan for the prevention of organ failure (LeoPARDS trial).
- He leads the "Emergency and Critical Care" therapeutic group within the Imperial Clinical Trials Unit.
- He is a Director of Research for the Intensive Care Foundation.
- He is Chair of the Experimental Medicine subgroup of the NIHR Critical Care Specialty Group helping to deliver nationwide clinical studies.
- He is leading a multidisciplinary group investigating the use of metabonomic analysis to develop novel sepsis diagnostics in peri-operative and critical care.
- He is a member of the management committee of the UK Critical Care Genomics group. This multi-disciplinary group brings together ICU clinicians, infectious diseases experts, geneticists and bio-statisticians to study the effects of genetic polymorphisms on the progression and outcome of severe sepsis. The GAinS study (Genomics Advances in Sepsis) has recruited more than 3000 patients with sepsis admitted to the ICU.
et al., 2018, Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock A Systematic Review and Meta-analysis, JAMA - Journal of the American Medical Association, Vol:319, ISSN:0098-7484, Pages:1889-1900
et al., 2016, Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis, New England Journal of Medicine, Vol:375, ISSN:0028-4793, Pages:1638-1648
et al., 2016, Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock. The VANISH Randomized Clinical Trial, Journal of the American Medical Association, Vol:316, ISSN:0002-9955, Pages:509-518
et al., 2016, Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study, Lancet Respiratory Medicine, Vol:4, ISSN:2213-2600, Pages:259-271
et al., 2015, Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation, Nanoscale, Vol:7, ISSN:2040-3364, Pages:13511-13520
et al., 2015, Monocyte Tumor Necrosis Factor-alpha-Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation, Critical Care Medicine, Vol:43, ISSN:0090-3493, Pages:1375-1385
et al., 2015, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, Lancet Respiratory Medicine, Vol:3, ISSN:2213-2600, Pages:53-60
et al., 2014, The interaction of vasopressin and corticosteroids in septic shock: A pilot randomized controlled trial, Critical Care Medicine, Vol:42, ISSN:0090-3493, Pages:1325-1333
et al., 2012, The Cardiopulmonary Effects of Vasopressin Compared With Norepinephrine in Septic Shock, Chest, Vol:142, ISSN:0012-3692, Pages:593-605
et al., 2008, Vasopressin versus norepinephrine infusion in patients with septic shock, New England Journal of Medicine, Vol:358, ISSN:0028-4793, Pages:877-887
et al., 2008, Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis, American Journal of Respiratory and Critical Care Medicine, Vol:178, ISSN:1073-449X, Pages:710-720
et al., 2010, The effects of vasopressin on acute kidney injury in septic shock, Intensive Care Medicine, Vol:36, ISSN:0342-4642, Pages:83-91