Imperial College London

Professor Anthony Gordon

Faculty of MedicineDepartment of Surgery & Cancer

Chair in Anaesthesia and Critical Care



+44 (0)20 3313 0657anthony.gordon




ICUCharing Cross HospitalCharing Cross Campus





Professor Anthony Gordon is the Chair in Anaesthesia and Critical Care at Imperial College and is a Consultant in Intensive Care Medicine based at Charing Cross Hospital.

He received his medical degree from St Bartholomew’s Medical School in 1993 and then undertook his postgraduate medical training across the North Thames regions with an additional year spent at The Royal North Shore Hospital in Sydney, Australia. He was awarded the Fellowship of the Royal College of Anaesthetists in 1999 and returned to Barts to obtain his research doctorate examining genetic susceptibility in sepsis.

Having obtained a dual CCST in Anaesthesia and Intensive Care Medicine he was awarded the Intensive Care Society visiting fellowship in 2005 and spent two years in Vancouver at St Paul’s Hospital, University of British Columbia as a post-doctorate fellow. During this time he also worked as the Director of Medical Development of a university spin-out company developing pharmacogenetic tests for use in the ICU.

Prof Gordon returned to the Imperial AHSC in November 2007, and was a recipient of a Clinician Scientist Fellowship award from the National Institute for Health Research (NIHR) and has recently been awarded an NIHR Research Professorship.

His research is focused on clinical and translational studies in sepsis. Particularly

  • He is Chief investigator on two multi-centre trials examining alternatives to catecholamines in septic shock. Early vasopressin use in septic shock and its interaction with corticosteroids (VANISH trial) and also levosimendan for the prevention of organ failure (LeoPARDS trial).
  • He leads the "Emergency and Critical Care" therapeutic group within the Imperial Clinical Trials Unit.
  • He is a Director of Research for the Intensive Care Foundation.
  • He is leading a multidisciplinary group investigating the use of metabonomic analysis to develop novel sepsis diagnostics in peri-operative and critical care.
  • He is a member of the management committee of the UK Critical Care Genomics group. This multi-disciplinary group brings together ICU clinicians, infectious diseases experts, geneticists and bio-statisticians to study the effects of genetic polymorphisms on the progression and outcome of severe sepsis. The GAinS study (Genomics Advances in Sepsis) has recruited more than 3000 patients with sepsis admitted to the ICU.

Selected Publications

Journal Articles

Gordon AC, Perkins GD, Singer M, et al., 2016, Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis., N Engl J Med

Gordon AC, Mason AJ, Thirunavukkarasu N, et al., 2016, Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock. The VANISH Randomized Clinical Trial, Journal of the American Medical Association, Vol:316, ISSN:0002-9955, Pages:509-518

Davenport EE, Burnham KL, Radhakrishnan J, et al., 2016, Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study, Lancet Respiratory Medicine, Vol:4, ISSN:2213-2600, Pages:259-271

Herrmann IK, Bertazzo S, O'Callaghan DJP, et al., 2015, Differentiating sepsis from non-infectious systemic inflammation based on microvesicle-bacteria aggregation, Nanoscale, Vol:7, ISSN:2040-3364, Pages:13511-13520

O'Callaghan DJP, O'Dea KP, Scott AJ, et al., 2015, Monocyte Tumor Necrosis Factor-alpha-Converting Enzyme Catalytic Activity and Substrate Shedding in Sepsis and Noninfectious Systemic Inflammation, Critical Care Medicine, Vol:43, ISSN:0090-3493, Pages:1375-1385

Rautanen A, Mills TC, Gordon AC, et al., 2015, Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study, Lancet Respiratory Medicine, Vol:3, ISSN:2213-2600, Pages:53-60

Gordon AC, Mason AJ, Perkins GD, et al., 2014, The interaction of vasopressin and corticosteroids in septic shock: A pilot randomized controlled trial, Critical Care Medicine, Vol:42, ISSN:0090-3493, Pages:1325-1333

Gordon AC, Wang N, Walley KR, et al., 2012, The Cardiopulmonary Effects of Vasopressin Compared With Norepinephrine in Septic Shock, Chest, Vol:142, ISSN:0012-3692, Pages:593-605

Gordon AC, Russell JA, Walley KR, et al., 2010, The effects of vasopressin on acute kidney injury in septic shock, Intensive Care Medicine, Vol:36, ISSN:0342-4642, Pages:83-91

Wurfel MM, Gordon AC, Holden TD, et al., 2008, Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis, American Journal of Respiratory and Critical Care Medicine, Vol:178, ISSN:1073-449X, Pages:710-720

Russell JA, Walley KR, Singer J, et al., 2008, Vasopressin versus norepinephrine infusion in patients with septic shock, New England Journal of Medicine, Vol:358, ISSN:0028-4793, Pages:877-887

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