Imperial College London
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Professor Anthony Gordon

Faculty of Medicine, Department of Surgery & Cancer

Chair in Anaesthesia and Critical Care
 
 
 
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Contact

 

anthony.gordon

 
 
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Location

 

ICUQueen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{DeMerle:2021:10.1097/CCM.0000000000004842,
author = {DeMerle, KM and Angus, DC and Baillie, JK and Brant, E and Calfee, CS and Carcillo, J and Chang, C-CH and Dickson, R and Evans, I and Gordon, AC and Kennedy, J and Knight, JC and Lindsell, CJ and Liu, V and Marshall, JC and Randolph, AG and Scicluna, BP and Shankar-Hari, M and Shapiro, NI and Sweeney, TE and Talisa, VB and Tang, B and Thompson, BT and Tsalik, EL and van, der Poll T and van, Vught LA and Wong, HR and Yende, S and Zhao, H and Seymour, CW},
doi = {10.1097/CCM.0000000000004842},
journal = {Critical Care Medicine},
pages = {748--759},
title = {Sepsis subclasses: a framework for development and interpretation},
url = {http://dx.doi.org/10.1097/CCM.0000000000004842},
volume = {49},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Sepsis is defined as a dysregulated host response to infection that leads to life-threatening acute organ dysfunction. It afflicts approximately 50 million people worldwide annually and is often deadly, even when evidence-based guidelines are applied promptly. Many randomized trials tested therapies for sepsis over the past 2 decades, but most have not proven beneficial. This may be because sepsis is a heterogeneous syndrome, characterized by a vast set of clinical and biologic features. Combinations of these features, however, may identify previously unrecognized groups, or "subclasses" with different risks of outcome and response to a given treatment. As efforts to identify sepsis subclasses become more common, many unanswered questions and challenges arise. These include: 1) the semantic underpinning of sepsis subclasses, 2) the conceptual goal of subclasses, 3) considerations about study design, data sources, and statistical methods, 4) the role of emerging data types, and 5) how to determine whether subclasses represent "truth." We discuss these challenges and present a framework for the broader study of sepsis subclasses. This framework is intended to aid in the understanding and interpretation of sepsis subclasses, provide a mechanism for explaining subclasses generated by different methodologic approaches, and guide clinicians in how to consider subclasses in bedside care.
AU  - DeMerle,KM
AU  - Angus,DC
AU  - Baillie,JK
AU  - Brant,E
AU  - Calfee,CS
AU  - Carcillo,J
AU  - Chang,C-CH
AU  - Dickson,R
AU  - Evans,I
AU  - Gordon,AC
AU  - Kennedy,J
AU  - Knight,JC
AU  - Lindsell,CJ
AU  - Liu,V
AU  - Marshall,JC
AU  - Randolph,AG
AU  - Scicluna,BP
AU  - Shankar-Hari,M
AU  - Shapiro,NI
AU  - Sweeney,TE
AU  - Talisa,VB
AU  - Tang,B
AU  - Thompson,BT
AU  - Tsalik,EL
AU  - van,der Poll T
AU  - van,Vught LA
AU  - Wong,HR
AU  - Yende,S
AU  - Zhao,H
AU  - Seymour,CW
DO  - 10.1097/CCM.0000000000004842
EP  - 759
PY  - 2021///
SN  - 0090-3493
SP  - 748
TI  - Sepsis subclasses: a framework for development and interpretation
T2  - Critical Care Medicine
UR  - http://dx.doi.org/10.1097/CCM.0000000000004842
UR  - https://www.ncbi.nlm.nih.gov/pubmed/33591001
UR  - https://journals.lww.com/ccmjournal/Fulltext/2021/05000/Sepsis_Subclasses__A_Framework_for_Development_and.4.aspx
UR  - http://hdl.handle.net/10044/1/87165
VL  - 49
ER  -
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