Dr Seneviratne graduated with a BSc in Biomedical Sciences from Imperial College London. She was then awarded a 4 year MRes/PhD studentship by the British Heart Foundation Centre of Research Excellence at Imperial College, where under the supervision of Prof. Claudia Monaco at the Kennedy Institute of Rheumatology and Prof. Rob Krams in the Department of Bioengineering, she studied the influence of shear stress and the IRF5 transcription factor on macrophage polarisation, inflammation and the pathogenesis of atherosclerosis, focusing on the development of 'vulnerable' atherosclerotic plaques, which are associated with acute cardiovascular events.
Dr Seneviratne is now working with the Macrophage Differentiation group, which previously identified that intraplaque haemorrhage induces an ATF1-driven transcriptional pathway, generating an anti-inflammatory 'Mhem' macrophage phenotype with more efficient iron and cholesterol recycling properties, and that the anti-diabetic agent Metformin induces the Mhem phenotype via AMPK. Dr Seneviratne is now working to further characterise the ATF1-AMPK pathway in Mhem macrophages and investigate whether Metformin could potentially protect against atherosclerotic disease.
et al., 2017, Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis, Circulation, Vol:136, ISSN:0009-7322, Pages:1140-+
et al., 2016, "Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques" (vol 89B, pg 168, 2015), Journal of Molecular and Cellular Cardiology, Vol:91, ISSN:0022-2828, Pages:10-10
et al., 2013, Biomechanical factors and macrophages in plaque stability, Cardiovascular Research, Vol:99, ISSN:0008-6363, Pages:284-293