The Patel group draws on expertise in stem cell differentiation, materials synthesis and pharmaceutical chemistry to develop biomaterials that facilitate gene transfer to desired cell populations, engineer mRNA transcripts for controlled protein pharmacokinetics and application of RNA therapies in chronic disease.
Asha joined the department in 2018 after completing 4 years of postdoctoral training as an EPSRC eterm fellow in the laboratories of Professors Daniel Anderson and Robert Langer at Massachusetts Institute of Technology, USA. Here, she developed biodegradable, non-viral vectors for the inhaled delivery of mRNA to the lung.
Asha graduated with a first class honours degree in Pharmacy from King's College London in 2006 and remains a member of the General Pharmaceutical Council and Royal Pharmaceutical Society. In 2014, she was awarded her PhD by the University of Nottingham as part of the Doctoral Training Centre in Regenerative Medicine where she developed biomaterials that modulate human pluripotent stem cell and cardiomyocyte behaviour, under the guidance of Professors Chris Denning, Morgan Alexander and Martyn Davies.
et al., 2019, Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium, Advanced Materials, Vol:31, ISSN:0935-9648, Pages:1-7
et al., 2018, Isogenic pairs of hiPSC-CMs with hypertrophic cardiomyopathy/LVNC-associated ACTC1 E99K mutation unveil differential functional deficits, Stem Cell Reports, Vol:11, ISSN:2213-6711, Pages:1226-1243
et al., 2016, Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs, Angewandte Chemie International Edition, Vol:55, ISSN:1521-3757, Pages:13808-13812
et al., 2016, High throughput screening for discovery of materials that control stem cell fate, Current Opinion in Solid State & Materials Science, Vol:20, ISSN:1359-0286, Pages:202-211
et al., 2015, A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays, Biomaterials, Vol:61, ISSN:0142-9612, Pages:257-265
, 2020, Bioengineering Innovative Solutions for Cancer, Elsevier, ISBN:9780128138861