I use a novel combination of experimental, mathematical and bioinformatic techniques to investigate cell-mediated immunity. My aim is to develop a predictive mathematical model of the human in vivo CD8+ T cell response in order to prevent and alleviate viral infection.
Members of the GrouP
Ulrich Kadolsky (email@example.com)
Aidan Macnamara (firstname.lastname@example.org)
Sukhdeep Singh (email@example.com)
My initial training was in theoretical physics. I have a BSc in Physics (1st class hons. University College London), an MSc in Mathematics (distinction, Imperial College London) and a PhD in Theoretical Particle Physics (title: "Non Commutative Geometry", University of Durham). I then worked as a mathematical modeller for the UK government for 2 years before crossing disciplines to Mathematical Immunology. I held a Wellcome Trust Fellowship at Imperial College London and then a Leverhulme Trust Fellowship at the University of Oxford before returning to Imperial as a lecturer.
For research interests and selected publications please see my group webpage.
Funded PhD positions available:
Please contact me if you wish to discuss these opportunities further.
Macallan D, Busch R, Asquith B, 2019, Current estimates of T cell kinetics in humans, Current Opinion in Systems Biology, ISSN:2452-3100
et al., 2018, Inhibitory killer-cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV and HTLV-1, Science Immunology, Vol:3, ISSN:2470-9468
et al., 2018, Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness, Plos Biology, Vol:16, ISSN:1544-9173
et al., 2018, Different selected mechanisms attenuated the inhibitory interaction of KIR2DL1 with C2+ HLA-C in two indigenous human populations in Southern Africa, Journal of Immunology, ISSN:1550-6606
et al., 2017, The fate and lifespan of human monocyte subsets in steady state and systemic inflammation, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1913-1923