I use a novel combination of experimental, mathematical and bioinformatic techniques to investigate cell-mediated immunity. My aim is to develop a predictive mathematical model of the human in vivo CD8+ T cell response in order to prevent and alleviate viral infection.
Members of the GrouP
Ulrich Kadolsky (email@example.com)
Aidan Macnamara (firstname.lastname@example.org)
Sukhdeep Singh (email@example.com)
My initial training was in theoretical physics. I have a BSc in Physics (1st class hons. University College London), an MSc in Mathematics (distinction, Imperial College London) and a PhD in Theoretical Particle Physics (title: "Non Commutative Geometry", University of Durham). I then worked as a mathematical modeller for the UK government for 2 years before crossing disciplines to Mathematical Immunology. I held a Wellcome Trust Fellowship at Imperial College London and then a Leverhulme Trust Fellowship at the University of Oxford before returning to Imperial as a lecturer.
For research interests and selected publications please see my group webpage.
Funded PhD positions available:
Please contact me if you wish to discuss these opportunities further.
Asquith R, Inhibitory killer-cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV and HTLV-1, Science Immunology
et al., 2018, Human T-SCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness, Plos Biology, Vol:16, ISSN:1545-7885
et al., 2018, Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2(+) HLA-C in Two Indigenous Human Populations in Southern Africa, Journal of Immunology, Vol:200, ISSN:0022-1767, Pages:2640-2655
et al., 2017, The fate and lifespan of human monocyte subsets in steady state and systemic inflammation, Journal of Experimental Medicine, Vol:214, ISSN:0022-1007, Pages:1913-1923
et al., 2017, HIV-1 adaptation to NK cell-mediated immune pressure, Plos Pathogens, Vol:13, ISSN:1553-7366