Publications
90 results found
KNOCKAERT M, LOCKETT A, CLARYSSE B, et al., 2005, Do human capital and fund characteristics drive follow-up behaviour of early stage high tech VCs?
This paper uses a unique dataset to examine the neglected but important issue concerning the relationship between the human capital and fund characteristics of venture capitalists and post-investment follow-up behavior in early stage high tech investments. We found no indication that involvement in monitoring activities by the investment manager is determined by either fund or human capital characteristics. In relation to value-adding activities, human capital variables were the most important, with previous consulting experience and entrepreneurial experience contributing to a higher involvement in valueadding activities. Furthermore, the diversity of an investment manager’s portfolio was negatively related to involvement in value-adding activities. Finally, with respect to fund level characteristics, we found that investment managers of captive funds were less involved in value-adding activities.
Neyt MJ, Albrecht JA, Clarysse B, et al., 2005, Cost-effectiveness of Herceptin®:: A standard cost model for breast-cancer treatment in a Belgian university hospital, INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE, Vol: 21, Pages: 132-137, ISSN: 0266-4623
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- Citations: 24
Knockaert M, Clarysse B, Wright M, 2005, How do early stage hightechnology investors select their investments?, R&D Management
Clarysse B, Wright M, Lockett A, et al., 2005, Spinning out new ventures: a typology of incubation strategies from European research institutions, JOURNAL OF BUSINESS VENTURING, Vol: 20, Pages: 183-216, ISSN: 0883-9026
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- Citations: 417
Heirman A, Clarysse B, 2004, How and Why do Research-Based Start-Ups Differ at Founding? A Resource-Based Configurational Perspective, The Journal of Technology Transfer, Vol: 29, Pages: 247-268
This paper studies the initial resources on which new organizations are based and how these resources interact with the institutional origin and market characteristics. Using a unique hand-collected data set of research-based start-ups (RBSUs), we empirically test how technological, financial and human resources relate to each other to form distinct starting resource configurations. We find four different start- ing configurations: "venture capital-backed start-ups," "prospectors," "product start-ups" and "transitional start-ups". The results show that VC-backed start-ups are a minority while half of the firms start as prospectors. Market complexity and growth prospects influence the probability of starting with venture capital. The unclearness of the product market at founding characterizes prospectors, while product start-ups mostly have an almost market-ready product targeted at an international niche market. Transitional starters initially commercialize technical know-how through consulting and become product oriented later on. This discussion contributes to the debate concerning the interplay of environment and firm resources.
Moray N, Clarysse B, 2004, Institutional change and the resource flows going to spin out projects: the case of imec
This study takes an institutional perspective on spinning off ventures as a venue for commercialising research. The central question dealt with is the following: are the resource endowments of spin-outs at time of founding influenced by the way in which the overall technology transfer process is organised at the parent organisation? We have selected a research institute known for its international research excellence and with a track record in spinning off ventures: IMEC (Leuven, Belgium). We questioned all senior managers involved in technology transfer and the founders of the academic ventures set up between 1987 - 2002. The basic argument of the research is that changes in the internal institutional environment -- and the spin out policy in particular -- co-evolve with a changing overall tendency in the amount of resources endowed to the academic ventures. More specifically, we identify three generations of academic ventures displaying the main organisational changes in technology transfer policies pertaining to spin off companies.
Heirman A, Clarysse B, 2004, Do intangible assets and pre-founding R&D efforts matter for innovation speed in start-ups?
The launch of the first product is an important event for start-ups, because it takes the new venture closer to growth, profitability and financial independence. However, entrepreneurship literature lacks theory and data on new product development and innovation speed. Integrating insights form new product development literature with resource-based theory, we construct a conceptual framework concerning the antecedents of innovation speed in start-ups. In particular, we argue that pre-founding R&D efforts and intangible assets such as team tenure, experience of founders, and collaborations with third parties are important for innovation speed. We collected a unique dataset on 99 research-based start-ups (RBSUs) and use an event-history approach to test our model. We find that RBSUs differ significantly in their starting conditions and that these differences have a significant effect on the time it takes to launch the first product. The impact of starting conditions on innovation speed differs however between software, medical-related, telecom and other technologies. Although intuition suggests that start-ups that are further in the product development cycle at founding launch their first product faster, we find that software firms starting with a beta-version experience slower product launch. Next, it is shown that team tenure and experience of founders leads to faster product launch. Contrary to expectations, alliances with other firms do not significantly affect innovation speed and collaborations with universities lead to longer development times. The insights of this study enhance our understanding of product development processes in start-ups and the differences between slow growers and fast growers.
Clarysse B, Moray N, 2004, A process study of entrepreneurial team formation: the case of a research-based spin-off, JOURNAL OF BUSINESS VENTURING, Vol: 19, Pages: 55-79, ISSN: 0883-9026
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- Citations: 304
Heirman A, Clarysse B, Haute VVD, 2003, Starting resource configurations of research-based start-ups and the interaction with technology, institutional background, and industrial dynamics
We study the starting resources of start-ups, which develop and market new products or services based upon a proprietary technology or skill. We define these companies as research-based start-ups (RBSUs). We look at how technological, financial and human resources at founding cluster together to form different starting resource configurations. Using a unique hand-collected dataset of RBSUs in Belgium, we find four different types of starting configurations: "Venture Capital-backed start-ups," "Prospectors," "Product start-ups" and "Transitional start-ups". This study shows that these different types of starting resource configurations are not only empirically distinct but can also be conceptually explained by internal factors such as the entrepreneurial orientation at start-up and external factors such as the origin of the firm and the characteristics of the industry in which the firm competes.
Everaert K, Delanghe J, Vanderkelen M, et al., 2003, Urinary plasma protein patterns in acute prostatitis, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol: 41, Pages: 79-84, ISSN: 1434-6621
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- Citations: 10
Vandevelde A, Dierdonck RV, Clarysse B, 2002, Is design-manufacturing integration that important?
There is limited empirical evidence to support the importance of design-manufacturing (DM) integration on the performance of new product development projects. This article focuses on the impact of integration processes and their outcomes on multidimensional project performance. When considering integration as interaction processes, we find that the degree of interaction is positively correlated with respect for time and prestige. If one succeeds in smoothing the production start-up, which is an outcome of integration, a better respect for time, budget and technical specifications is realized. Finally, we provide some insights into the perceived room to improve integration. Even though perceptions do not always correspond with reality, it is interesting to examine them since product development decisions are often taken in response to an individuals perceptions (Kleinschmidt & Cooper, 1995).
Vandevelde A, Dierdonck RV, Clarysse B, 2002, Managing the design-manufacturing interface.
This article describes the major barriers across the design-manufacturing interface and examines ways to overcome them to achieve a smooth production start-up. An integration model reveals that formalization facilitates a smooth production start-up. Independent of the degree of formalization during the early development stages, a formal approach is preferred when the new product is introduced into production. Another facilitating factor is the empathy from design towards manufacturing, which can be stimulated by managerial actions. Although the complexity and newness of product and technology hinder a smooth production start-up, their effect seems to vanish by introducing formalization and by striving for a design team that has empathy towards manufacturing.
Cincera M, Clarysse B, 2002, Belgian report on science, technology and innovation
Capron H, Cincera M, 2002, The participation of Belgium to the European R&D programmes
Potterie BVPDL, Peeters C, 2002, S&T policies, R&D and economic growth: empirical evidence and recent trends
Cincera M, Clarysse B, 2002, Further insight into the performance of the Belgian innovation system
Vandevelde A, Dierdonck RV, Clarysse B, 2001, The role of physical prototyping in the product development process.
The aim of this paper was to achieve a better understanding of the specific role of physical prototyping in the product development process. Data from a survey of 25 companies revealed that the direct effect of prototyping on multidimensional project performance is limited. However, physical prototyping appears to affect process and product concept characteristics. More particularly, it improves interdisciplinary communication, supports a concurrent, time-oriented approach and collaboration in balanced teams. It enhances the project leader's championing, and increases the support of senior management and product quality. Finally, physical prototyping indirectly affects project performance via these modified characteristics.
Clarysse B, Muldur U, 2001, Regional cohesion in Europe? An analysis of how EU public RTD support influences the techno-economic regional landscape, RESEARCH POLICY, Vol: 30, Pages: 275-296, ISSN: 0048-7333
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- Citations: 32
Clarysse B, Debackere K, Heirman A, 2001, The blurring boundaries of research: towards a property rights explanation of knowledge transfer in biotechnology, Cahiers Economiques de Bruxelles, Vol: 169, Pages: 85-113
This paper investigates how the different mechanisms for knowledge transfer are linked to the underlying technological life cycle. Following the most recent developments in the organizational economics literature, we analyze knowledge transfer from an incentive point of view. We modified the basic version of the incomplete contracts model (or property rights model) to include knowledge as an asset. The empirical hypotheses which can be derived from this model are contrasted to other streams of thought such as organizational ecology. Using this comparison as a guideline, we undertake a first empirical test of this property rights model in two technological subfields of biotechnology: monoclonal antibodies and protein engineering. The results, though tentative, are challenging: the property rights model clearly adds to our insights in spin-offs as a mechanism for knowledge transfer and in the incentive factors that influence an organization's decision to enter a technological collaboration with a university or another biotech firm.
Everaert K, Delanghe J, Vande Wiele C, et al., 1998, Urinary α<sub>1</sub>-microglobulin detects uropathy.: A prospective study in 483 urological patients, CLINICAL CHEMISTRY AND LABORATORY MEDICINE, Vol: 36, Pages: 309-315, ISSN: 1434-6621
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- Citations: 25
Debackere K, Clarysse B, 1998, Advanced bibliometric methods to model the relationship between entry behavior and networking in emerging technological communities, 4th International Conference on Science and Technology Indicators, Publisher: WILEY, Pages: 49-58, ISSN: 0002-8231
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- Citations: 7
Debackere K, Clarysse B, 1997, The impact of networking on innovative performance of new biotechnology firms: a combined econometric and scientometric analysis.
This paper examines the impact of firm resources and network capabilities on innovative performance in a population of 117 biotech companies. After controlling for the traditional size and scope effects, the managerial focus of the firms' R&D activities and their collaboration activities with external partners (in majority universir-ties) become the central variables in ou study. A (unbalanced) panel nalysis of the firms over a twenty-year period shows the highly significant impact of research focus and networking activities on innovative performance.
Debackere K, Clarysse B, 1997, On the design of knowledge tranfer mechanism: applying the incomplete contracts model to developments in biotechnology.
This paper proposes a framework on how different mechanisms for knowledge transfer can be linked to the underlying technological life-cycle. Drawing on recent insights from the organizational economics literature, we analyze the design of knowledge transfer mechanisms and structures from an incentive point of view. The basic version of the incomplete contracts model (or property rights model) was adapted to include knowledge as an asset. Several empirical hypotheses can be derived from this model. They are contrasted with other theoretical approaches to model organizational growth and development, as we are specifically interested in the use of new ventures creation as a technology transfer mechanism. Using this framework as a starting point, a limited empirical test is two sub-fields of modern biotechnology : monoclonal antibodies and protein engineering. The results are interesting: the property rights model may add to current insights on spin-offs as a mechanism for knowledge transfer as well as to a better understanding of the incentive structures that influence an organization's decision to enter a technological collaboration with a university or another biotech firm.
Debackere K, Clarysse B, 1997, Towards an ecological understanding of firm founding and growth in emergent populations.
Organizational ecology is a fast growing domain in organization theory. During the past few years, the theory has evolved from a collection of rather unrelated concepts towards an integrated model of failure and founding, which has been tested with advanced empirical techniques. Despite this increasing convergence within the ecological boundaries, little integration occurs with other intellectual streams which can either be considered as complementary to a density dependence model or as a challenge to the basic assumptions of this model. This paper presents both a review of the theoretical and empirical methods developed during the past five years and an assessment of future research opportunities : can institutional theory, strategic management and industrial economics enrich and stretch the boundaries of the ecological model?
Debackere K, Clarysse B, Rappa MA, 1996, Dismantling the ivory tower: The influence of networks on innovative output in emerging technologies, TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE, Vol: 53, Pages: 139-154, ISSN: 0040-1625
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- Citations: 18
Clarysse B, Debackere K, Rappa MA, 1996, Modeling the persistence of organizations in an emerging field: The case of hepatitis C, RESEARCH POLICY, Vol: 25, Pages: 671-687, ISSN: 0048-7333
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- Citations: 8
Clarysse B, Debackere K, Van Dierdonck R, 1996, Research Networks And Organisational Mobility In An Emerging Technological Field: The Case Of Plant Biotechnology, Economics of Innovation and New Technology, Vol: 4, Pages: 77-96
This paper builds on social network theory to understand technological development. Based on the empirical evidence of 367 research organisations in plant biotechnology over a nineteen-year period, we demonstrate how a structural analysis of the research network within the technological community is used to identify four collaboration-based strategic groups of research organisations. The emergence of these groups can be linked to technological breakthroughs in the field. Analyses of the four clusters point to the influence of research collaborations on stratification within an evolving technological domain. Finally, as archival data sources are used to detect incidences of collaborative research and to trace the evolution of R&D networks in an emerging field, we conclude with a discussion of the potential contribution of bibliometric data to understand the development of new technologies in their early, pre-commercial phases.
Debackere K, Clarysse B, VanDierdonck R, 1995, Technology dynamics: Implications for regional development, International Symposium on Management of Technology and Regional Development in a Global Environment - An International Perspectives, Publisher: PAUL CHAPMAN PUBL LTD, Pages: 13-28
DEBACKERE K, RAPPA MA, CLARYSSE B, 1995, Autonomy and persistence in industrial research: The dilemma revisited, 55th Annual Meeting of the Academy-of-Management - Best Papers Proceedings, Publisher: ACAD MANAGEMENT, Pages: 417-421, ISSN: 0065-0668
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- Citations: 1
DEBACKERE K, CLARYSSE B, WIJNBERG NM, et al., 1994, SCIENCE AND INDUSTRY - A THEORY OF NETWORKS AND PARADIGMS, TECHNOLOGY ANALYSIS & STRATEGIC MANAGEMENT, Vol: 6, Pages: 21-37, ISSN: 0953-7325
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- Citations: 25
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