Imperial College London
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Dr. Beth Holder

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer in Maternal and Fetal Health
 
 
 
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Contact

 

+44 (0)20 7594 1773b.holder Website

 
 
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Location

 

3 008Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wilcox:2017:10.3389/fimmu.2017.01294,
author = {Wilcox, CR and Holder, E and Jones, CE},
doi = {10.3389/fimmu.2017.01294},
journal = {Frontiers in Immunology},
title = {Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy},
url = {http://dx.doi.org/10.3389/fimmu.2017.01294},
volume = {8},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life. Transcytosis of IgG occurs via binding with the neonatal Fc receptor (FcRn) in the placental synctiotrophoblast. As maternal vaccination becomes an increasingly important strategy for the protection of young infants, improving our understanding of transplacental transfer and the factors that may affect this will become increasingly important, especially in low-income countries where the burden of morbidity and mortality is highest. This review highlights factors of relevance to maternal vaccination that may modulate placental transfer—IgG subclass, glycosylation of antibody, total maternal IgG concentration, maternal disease, infant gestational age, and birthweight—and outlines the conflicting evidence and questions that remain regarding the complexities of these relationships. Furthermore, the intricacies of the Ab–FcRn interaction remain poorly understood and models that may help address future research questions are described.
AU  - Wilcox,CR
AU  - Holder,E
AU  - Jones,CE
DO  - 10.3389/fimmu.2017.01294
PY  - 2017///
SN  - 1664-3224
TI  - Factors affecting the FcRn-mediated transplacental transfer of antibodies and implications for vaccination in pregnancy
T2  - Frontiers in Immunology
UR  - http://dx.doi.org/10.3389/fimmu.2017.01294
UR  - http://hdl.handle.net/10044/1/51322
VL  - 8
ER  -
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