Imperial College London

ProfessorBeateKampmann

Faculty of MedicineDepartment of Medicine

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 2758b.kampmann Website

 
 
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Assistant

 

Mrs Krupa Shukla +44 (0)20 7594 8839

 
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Location

 

220Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

176 results found

Lindsey BB, Armitage EP, Kampmann B, de Silva Tet al., 2019, The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review, LANCET INFECTIOUS DISEASES, Vol: 19, Pages: E110-E119, ISSN: 1473-3099

JOURNAL ARTICLE

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid Pet al., 2019, Moving toward Tuberculosis Elimination Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 199, Pages: 564-571, ISSN: 1073-449X

JOURNAL ARTICLE

White M, Idoko O, Sow S, Diallo A, Kampmann B, Borrow R, Trotter Cet al., 2019, Antibody kinetics following vaccination with MenAfriVac: an analysis of serological data from randomised trials, LANCET INFECTIOUS DISEASES, Vol: 19, Pages: 327-336, ISSN: 1473-3099

JOURNAL ARTICLE

Roy RB, Whittaker E, Seddon JA, Kampmann Bet al., 2019, Tuberculosis susceptibility and protection in children, LANCET INFECTIOUS DISEASES, Vol: 19, Pages: E96-E108, ISSN: 1473-3099

JOURNAL ARTICLE

Rice TF, Diavatopoulos DA, Smits GP, van Gageldonk PGM, Berbers GAM, van der Klis FR, Vamvakas G, Donaldson B, Bouqueau M, Holder B, Kampmann Bet al., 2019, Antibody responses to Bordetella pertussis and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy - a prospective, observational cohort study from the United Kingdom., Clin Exp Immunol

The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination programme in the United Kingdom has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate the persistence of maternal antibodies during infancy and the possible interference of maternal antibodies with infant responses to vaccines. We recruited mother-infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of immunoglobulin (Ig)G against pertussis toxin (PTx), filamentous haemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. Thirty-one mother-infant pairs were tested. Tdap-vaccinated women had significantly higher antibody against Tdap antigens, compared to unvaccinated women (DTx, P = 0·01; PTx, FHA, Prn and TTx, P < 0·001). All antibodies were actively transferred to the infants (transfer ratio  > 1) with higher transfer of DTx (P = 0·04) and TTx (P = 0·02) antibody in Tdap-vaccinated pregnancies compared to unvaccinated pregnancies. Infants from Tdap-vaccinated pregnancies had significantly elevated antibodies to all antigens at birth (P < 0.001) and at 7 weeks (FHA, Prn, TTx, P < 0·001; DTx, P = 0.01; PTx, P = 0·004) compared to infants from unvaccinated pregnancies. Infants from Tdap-vaccinated and -unvaccinated pregnancies had comparable antibody concentrations following primary pertussis immunization (PTx, P = 0·77; FHA, P = 0·58; Prn, P = 0·60; DTx, P = 0·09; TTx, P = 0·88). These results support maternal immunization as a method of protecting vulnerable infants

JOURNAL ARTICLE

Zhong Z, Haltalli M, Holder B, Rice T, Donaldson B, O'Driscoll M, Le-Doare K, Kampmann B, Tregoning JSet al., 2019, The impact of timing of maternal influenza immunization on infant antibody levels at birth, CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 195, Pages: 139-152, ISSN: 0009-9104

JOURNAL ARTICLE

Rachow A, Ivanova O, Wallis R, Charalambous S, Jani I, Bhatt N, Kampmann B, Sutherland J, Ntinginya NE, Evans D, Loennroth K, Niemann S, Schaible UE, Geldmacher C, Sanne I, Hoelscher M, Churchyard Get al., 2019, TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB - a study protocol, BMC PULMONARY MEDICINE, Vol: 19, ISSN: 1471-2466

JOURNAL ARTICLE

Seddon J, Whittaker E, Kampmann B, Lewinsohn D, Osman M, Hesseling A, Rustomjee R, Amanullah Fet al., The evolving research agenda for paediatric tuberculosis infection, Lancet Infectious Diseases, ISSN: 1473-3099

There are unique challenges facingthe diagnosis andmanagement of tuberculosis infection in children. Following exposure to aninfectioustuberculosiscase and subsequent infection, children frequently progress to tuberculosis disease more rapidly than adults.Increasingly, investigators recognize the concept of sub-clinical disease, an entity referring to early asymptomatic disease. Our understanding of the pathogenesis of tuberculosis in children remainslimitedbut could be improved through animal models, laboratory studiesevaluating the responses of blood or respiratory samplesto mycobacteria in vitro, as well as evaluating immune responses in children exposed to tuberculosis. Identifying children with sub-clinical disease, at high risk of progression toclinically apparentdisease, through biomarker discover, would mean that treatment could be targetedto those most likely to benefit.These studies could be embedded in large observational or interventional cohorts. The optimization and discovery of noveltreatments for tuberculosis infection in children need to account for mechanisms of action of tuberculosis drugs as well as child-specific factors including pharmacokinetics and appropriate formulations. In this article we present the result of discussions at a large international meeting and the series of research priorities that were developed.

JOURNAL ARTICLE

Munoz FM, Van Damme P, Dinleyici E, Clarke E, Kampmann B, Heath PT, Levy O, Leuridan E, Cutland C, Sobanjo-ter Meulen A, Marchant Aet al., 2018, The Fourth International Neonatal and Maternal Immunization Symposium (INMIS 2017): Toward Integrating Maternal and Infant Immunization Programs, MSPHERE, Vol: 3, ISSN: 2379-5042

JOURNAL ARTICLE

Whittaker E, Nicol MP, Zar HJ, Tena-Coki NG, Kampmann Bet al., 2018, Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Praharaj I, Parker EPK, Giri S, Allen DJ, Silas S, Revathi R, Kaliappan SP, John J, Prasad JH, Kampmann B, Iturriza-Gómara M, Grassly NC, Kang Get al., 2018, Influence of non-polio enteroviruses and the bacterial gut microbiota on oral poliovirus vaccine response: a study from south India., J Infect Dis

Background: Oral poliovirus vaccine (OPV) is less immunogenic in LMIC countries. We tested whether bacterial and viral components of the intestinal microbiota are associated with this phenomenon. Methods: We assessed prevalence of enteropathogens using TaqMan array cards 14 days before and at vaccination in 704 Indian infants (6-11 months) receiving monovalent type3 OPV (CTRI/2014/05/004588). Non-polio enterovirus (NPEV) serotypes were identified by VP1 sequencing. In 120 infants, pre-vaccination bacterial microbiota was characterised by 16S rRNA sequencing. Results: We detected 56 NPEV serotypes on the day of vaccination. Concurrent NPEVs were associated with a reduction in OPV seroconversion, consistent across species (odds ratios and 95% CIs of 0·57[0·36-0·90], 0·61[0·43-0·86], and 0·69[0·41-1·16] for species A, B, and C, respectively). Recently acquired enterovirus infections,detected at vaccination, but not 14 days earlier had greater interfering effect on mOPV3 sero-response compared to persistent infections,with enterovirus detected at both time points (44/127[35%] vs 63/129[49%] seroconversion,p=0.021). Abundance of specific bacterial taxa did not differ significantly according to OPV response, although microbiota diversity was higher in non-responders at the time of vaccination. Conclusion: Enteric viruses have greater impact on OPV response than the bacterial microbiota with recent enterovirus infections having greater inhibitory effect than persistent infections.

JOURNAL ARTICLE

Rice TF, Donaldson B, Bouqueau M, Kampmann B, Holder Bet al., 2018, Macrophage- but not monocyte-derived extracellular vesicles induce placental pro-inflammatory responses, PLACENTA, Vol: 69, Pages: 92-95, ISSN: 0143-4004

JOURNAL ARTICLE

Whittaker EA, Nicol M, Zar H, Tena-Coki G, Kampmann Bet al., Evidence of waning BCG responses in healthy children; time to introduce a booster?, Scientific Reports, ISSN: 2045-2322

JOURNAL ARTICLE

Usuf E, Mackenzie G, Ceesay L, Sowe D, Kampmann B, Roca Aet al., 2018, Vaccine wastage in The Gambia: a prospective observational study, BMC PUBLIC HEALTH, Vol: 18, ISSN: 1471-2458

JOURNAL ARTICLE

Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Chiotan DI, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Mendez-Echevarria A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Saleem-ur-Rehman, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim J-J, Furin J, Hesseling ACet al., 2018, Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis, PLOS MEDICINE, Vol: 15, ISSN: 1549-1676

JOURNAL ARTICLE

Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, Williams B, Williams A, Liebeschutz S, Riddell A, Bernatoniene J, Patel S, Martinez N, McMaster P, Basu-Roy R, Welch SBet al., 2018, Evaluating UK National Guidance for Screening of Children for Tuberculosis A Prospective Multicenter Study, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 197, Pages: 1058-1064, ISSN: 1073-449X

JOURNAL ARTICLE

Armitage ET, Camara J, Bah S, Forster AS, Clarke E, Kampmann B, de Silva TIet al., 2018, Acceptability of intranasal live attenuated influenza vaccine; influenza knowledge and vaccine intent in The Gambia, VACCINE, Vol: 36, Pages: 1772-1780, ISSN: 0264-410X

JOURNAL ARTICLE

Parker EPK, Praharaj I, Zekavati A, Lazarus RP, Giri S, Operario DJ, Liu J, Houpt E, Iturriza-Gomara M, Kampmann B, John J, Kang G, Grassly NCet al., 2018, Influence of the intestinal microbiota on the immunogenicity of oral rotavirus vaccine given to infants in south India, VACCINE, Vol: 36, Pages: 264-272, ISSN: 0264-410X

JOURNAL ARTICLE

Nonyane BAS, Nicol MP, Andreas NJ, Rimmele S, Schneiderhan-Marra N, Workman LJ, Perkins MD, Joos T, Broger T, Ellner JJ, Alland D, Kampmann B, Dorman SE, Zar HJet al., 2018, Serologic Responses in Childhood Pulmonary Tuberculosis, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 37, Pages: 1-9, ISSN: 0891-3668

JOURNAL ARTICLE

Mensah VA, Roetynck S, Kanteh EK, Bowyer G, Ndaw A, Oko F, Bliss CM, Jagne YJ, Cortese R, Nicosia A, Roberts R, D'Alessio F, Leroy O, Faye B, Kampmann B, Cisse B, Bojang K, Gerry S, Viebig NK, Lawrie AM, Clarke E, Imoukhuede EB, Ewer KJ, Hill AVS, Afolabi MOet al., 2017, Safety and Immunogenicity of Malaria Vectored Vaccines Given with Routine Expanded Program on Immunization Vaccines in Gambian Infants and Neonates: A Randomized Controlled Trial, FRONTIERS IN IMMUNOLOGY, Vol: 8, ISSN: 1664-3224

JOURNAL ARTICLE

Le Doare K, O'Driscoll M, Turner K, Seedat F, Russell NJ, Seale AC, Heath PT, Lawn JE, Baker CJ, Bartlett L, Cutland C, Gravett MG, Ip M, Madhi SA, Rubens CE, Saha SK, Schrag S, Sobanjo-ter Meulen A, Vekemans J, Kampmann Bet al., 2017, Intrapartum Antibiotic Chemoprophylaxis Policies for the Prevention of Group B Streptococcal Disease Worldwide: Systematic Review, CLINICAL INFECTIOUS DISEASES, Vol: 65, Pages: S143-S151, ISSN: 1058-4838

JOURNAL ARTICLE

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin Met al., 2017, Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Saso A, Kampmann B, 2017, Vaccine responses in newborns, SEMINARS IN IMMUNOPATHOLOGY, Vol: 39, Pages: 627-642, ISSN: 1863-2297

JOURNAL ARTICLE

Saso A, Donaldson B, Kampmann B, 2017, Uptake of Pertussis and Influenza Vaccinations in Pregnancy, Publisher: SPRINGER, Pages: 1508-1508, ISSN: 0340-6199

CONFERENCE PAPER

Le Doare K, Bellis K, Faal A, Birt J, Munblit D, Humphries H, Taylor S, Warburton F, Heath PT, Kampmann B, Gorringe Aet al., 2017, SIgA, TGF-beta 1, IL-10, and TNF alpha in Colostrum Are Associated with Infant Group B Streptococcus Colonization, FRONTIERS IN IMMUNOLOGY, Vol: 8, ISSN: 1664-3224

JOURNAL ARTICLE

de Silva TI, Gould V, Mohammed NI, Cope A, Meijer A, Zutt U, Reimerink J, Kampmann B, Hoschler K, Zambon M, Tregoning JSet al., 2017, Comparison of mucosal lining fluid sampling methods and influenza-specific IgA detection assays for use in human studies of influenza immunity, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 449, Pages: 1-6, ISSN: 0022-1759

JOURNAL ARTICLE

Turkova A, Kampmann B, 2017, Short course treatment for MDR TB: jumping the gun?, THORAX, Vol: 72, Pages: 773-773, ISSN: 0040-6376

JOURNAL ARTICLE

Bibby J, Saidu Y, Umesi A, Moneke-Anyanwoke N, Bashorun AO, Hydara MB, Adigweme I, Adetifa JU, Okoye M, Roberts E, Clemens R, Bandyopadhyay AS, Muhammad AK, Mulwa S, Royals M, Jarrahian C, Jeffries D, Kampmann B, Clarke Eet al., 2017, The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb, CLINICAL INFECTIOUS DISEASES, Vol: 65, Pages: 851-854, ISSN: 1058-4838

JOURNAL ARTICLE

Parker EPK, Praharaj I, John J, Kaliappan SP, Kampmann B, Kang G, Grassly NCet al., 2017, Changes in the intestinal microbiota following the administration of azithromycin in a randomised placebo-controlled trial among infants in south India, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

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