Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology



+44 (0)20 3313 8353b.lenhard Website




Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318




230ICTEM buildingHammersmith Campus





The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:

  • Structure and function of gene promoters
  • Function and genomic distribution of gene regulatory elements
  • Function of transcription factors
  • Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
  • Association of different modes of regulation with epigenetic marks and their inheritance

Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.



Börlin CS, Cvetesic N, Holland P, et al., 2019, Saccharomyces cerevisiae displays a stable transcription start site landscape in multiple conditions., Fems Yeast Res, Vol:19

Newton MD, Taylor BJ, Driessen RPC, et al., 2019, DNA stretching induces Cas9 off-target activity, Nature Structural & Molecular Biology, Vol:26, ISSN:1545-9993, Pages:185-+

Nash AJ, Lenhard B, 2018, A Novel Measure of Non-coding Genome Conservation Identifies Genomic Regulatory Blocks Within Primates., Bioinformatics

Marletaz F, Firbas PN, Maeso I, et al., 2018, Amphioxus functional genomics and the origins of vertebrate gene regulation, Nature, Vol:564, ISSN:0028-0836, Pages:64-+

Cvetesic N, Leitch HG, Borkowska M, et al., 2018, SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA, Genome Research, Vol:28, ISSN:1088-9051, Pages:1943-1956

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