The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation, Plos Biology, ISSN:1544-9173
et al., 2019, Saccharomyces cerevisiae displays a stable transcription start site landscape in multiple conditions, Fems Yeast Research, Vol:19, ISSN:1567-1356
et al., 2019, DNA stretching induces Cas9 off-target activity, Nature Structural and Molecular Biology, Vol:26, ISSN:1545-9985, Pages:185-192
Lenhard B, Sternberg MJE, 2019, Computation Resources for Molecular Biology: Special Issue 2019, Journal of Molecular Biology, ISSN:0022-2836