Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology



+44 (0)20 3313 8353b.lenhard Website




Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318




230ICTEM buildingHammersmith Campus





The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:

  • Structure and function of gene promoters
  • Function and genomic distribution of gene regulatory elements
  • Function of transcription factors
  • Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
  • Association of different modes of regulation with epigenetic marks and their inheritance

Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.



Karimi MM, Guo Y, Cui X, et al., 2021, The order and logic of CD4 CD8 lineage choice and differentiation in mouse thymus, Nature Communications, Vol:12, ISSN:2041-1723

Yu C, Cvetesic N, Hisler V, et al., 2020, TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage, Nature Communications, Vol:11, ISSN:2041-1723

Beltran T, Pahita E, Ghosh S, et al., 2020, Integrator is recruited to promoter-proximally paused RNA Pol II to generate Caenorhabditis elegans piRNA precursors, Embo Journal, ISSN:0261-4189

Cvetesic N, Borkowska M, Hatanaka Y, et al., 2020, Global regulatory transitions at core promoters demarcate the mammalian germline cycle

Wragg JW, Roos L, Vucenovic D, et al., 2020, Embryonic tissue differentiation is characterized by transitions in cell cycle dynamic-associated core promoter regulation, Nucleic Acids Research, Vol:48, ISSN:0305-1048, Pages:8374-8392

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