The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., 2018, JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework., Nucleic Acids Res, Vol:46, Pages:D260-D266
et al., 2017, Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation, Nature Communications, Vol:8, ISSN:2041-1723
Cvetesic N, Lenhard B, 2017, Core promoters across the genome, Nature Biotechnology, Vol:35, ISSN:1087-0156, Pages:123-124
et al., 2017, Conserved non-coding elements: developmental gene regulation meets genome organization., Nucleic Acids Res, Vol:45, Pages:12611-12624
et al., 2017, Transcriptional memory of cells of origin overrides beta-catenin requirement of MLL cancer stem cells, Embo Journal, Vol:36, ISSN:0261-4189, Pages:3139-3155