The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., 2018, Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation, Nature Immunology, Vol:19, ISSN:1529-2908, Pages:932-+
et al., 2018, BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells, Brain, Vol:141, ISSN:0006-8950, Pages:2299-2311
Li C, Lenhard B, Luscombe NM, 2018, Integrated analysis sheds light on evolutionary trajectories of young transcription start sites in the human genome, Genome Research, Vol:28, ISSN:1088-9051, Pages:676-688
et al., 2018, Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte, Nature, Vol:555, ISSN:0028-0836, Pages:392-+
et al., 2018, Distinct core promoter codes drive transcription initiation at key developmental transitions in a marine chordate, Bmc Genomics, Vol:19, ISSN:1471-2164