The development of complex organisms critically depends upon regulation of gene activity across dozens, hundreds or millions of cells in time and space. This regulation ensures the fidelity of development of complex structures and the overall function of the organism. Its disruption therefore often leads to disease.
We study gene regulation at the genomewide level using computational genomics and epigenomics. Our major research interests focus on:
- Structure and function of gene promoters
- Function and genomic distribution of gene regulatory elements
- Function of transcription factors
- Regulation of the production of transcription factors i.e. transcriptional regulatory networks (TRNs)
- Association of different modes of regulation with epigenetic marks and their inheritance
Our recent work centres on the functional classification of core promoters, the development of methods to correctly assign regulatory elements to the genes they regulate, and the role of the epigenome in guiding development.
et al., 2019, Saccharomyces cerevisiae displays a stable transcription start site landscape in multiple conditions., Fems Yeast Res, Vol:19
et al., 2019, DNA stretching induces Cas9 off-target activity, Nature Structural & Molecular Biology, Vol:26, ISSN:1545-9993, Pages:185-+
Nash AJ, Lenhard B, 2018, A Novel Measure of Non-coding Genome Conservation Identifies Genomic Regulatory Blocks Within Primates., Bioinformatics
et al., 2018, Amphioxus functional genomics and the origins of vertebrate gene regulation, Nature, Vol:564, ISSN:0028-0836, Pages:64-+
et al., 2018, SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA, Genome Research, Vol:28, ISSN:1088-9051, Pages:1943-1956