Imperial College London

ProfessorBorisLenhard

Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 3313 8353b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

154 results found

Ghamari A, van de Corput MPC, Thongjuea S, van Cappellen WA, van IJcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FGet al., 2013, In vivo live imaging of RNA polymerase II transcription factories in primary cells (vol 27, pg 767, 2013), GENES & DEVELOPMENT, Vol: 27, Pages: 1434-1434, ISSN: 0890-9369

Journal article

Ghamari A, van de Corput MPC, Thongjuea S, van Cappellen WA, van IJcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FGet al., 2013, In vivo live imaging of RNA polymerase II transcription factories in primary cells (vol 27, pg 767, 2013), GENES & DEVELOPMENT, Vol: 27, Pages: 1216-1216, ISSN: 0890-9369

Journal article

Sheffield NC, Thurman RE, Song L, Safi A, Stamatoyannopoulos JA, Lenhard B, Crawford GE, Furey TSet al., 2013, Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions, GENOME RESEARCH, Vol: 23, Pages: 777-788, ISSN: 1088-9051

Journal article

Carvalho RH, Hou J, Haberle V, Aerts J, Grosveld F, Lenhard B, Philipsen Set al., 2013, Genomewide DNA Methylation Analysis Identifies Novel Methylated Genes in Non-Small-Cell Lung Carcinomas, JOURNAL OF THORACIC ONCOLOGY, Vol: 8, Pages: 562-573, ISSN: 1556-0864

Journal article

Mylona A, Andrieu-Soler C, Thongjuea S, Martella A, Soler E, Jorna R, Hou J, Kockx C, van Ijcken W, Lenhard B, Grosveld Fet al., 2013, Genome-wide analysis shows that Ldb1 controls essential hematopoietic genes/pathways in mouse early development and reveals novel players in hematopoiesis, BLOOD, Vol: 121, Pages: 2902-2913, ISSN: 0006-4971

Journal article

Ghamari A, van de Corput MPC, Thongjuea S, van Cappellen WA, van IJcken W, van Haren J, Soler E, Eick D, Lenhard B, Grosveld FGet al., 2013, In vivo live imaging of RNA polymerase II transcription factories in primary cells, GENES & DEVELOPMENT, Vol: 27, Pages: 767-777, ISSN: 0890-9369

Journal article

Danks G, Campsteijn C, Parida M, Butcher S, Doddapaneni H, Fu B, Petrin R, Metpally R, Lenhard B, Wincker P, Chourrout D, Thompson EM, Manak JRet al., 2013, OikoBase: a genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica, NUCLEIC ACIDS RESEARCH, Vol: 41, Pages: D845-D853, ISSN: 0305-1048

Journal article

Harmston N, Barešić A, Lenhard B, 2013, The mystery of extreme non-coding conservation, Philosophical Transactions of the Royal Society B: Biological Sciences, Vol: 368

Regions of several dozen to several hundred base pairs of extreme conservation have been found in non-coding regions in all metazoan genomes. The distribution of these elements within and across genomes has suggested that many have roles as transcriptional regulatory elements in multi-cellular organization, differentiation and development. Currently, there is no known mechanism or function that would account for this level of conservation at the observed evolutionary distances. Previous studies have found that, while these regions are under strong purifying selection, and not mutational coldspots, deletion of entire regions in mice does not necessarily lead to identifiable changes in phenotype during development. These opposing findings lead to several questions regarding their functional importance and why they are under strong selection in the first place. In this perspective, we discuss the methods and techniques used in identifying and dissecting these regions, their observed patterns of conservation, and review the current hypotheses on their functional significance.

Journal article

van Riel B, Pakozdi T, Brouwer R, Monteiro R, Tuladhar K, Franke V, Bryne JC, Jorna R, Rijkers E-J, van Ijcken W, Andrieu-Soler C, Demmers J, Patient R, Soler E, Lenhard B, Grosveld Fet al., 2012, A Novel Complex, RUNX1-MYEF2, Represses Hematopoietic Genes in Erythroid Cells, MOLECULAR AND CELLULAR BIOLOGY, Vol: 32, Pages: 3814-3822, ISSN: 0270-7306

Journal article

de Santiago I, Brookes E, Morris KJ, Carroll T, Xie SQ, Hebenstreit D, Lenhard B, Ragoussis J, Teichmann SA, Pombo Aet al., 2012, Polycomb complexes co-associate with a specific RNA polymerase II variant inES cells, Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Publisher: MARY ANN LIEBERT INC, Pages: A20-A20, ISSN: 1043-0342

Conference paper

Thurman RE, Rynes E, Humbert R, Vierstra J, Maurano MT, Haugen E, Sheffield NC, Stergachis AB, Wang H, Vernot B, Garg K, John S, Sandstrom R, Bates D, Boatman L, Canfield TK, Diegel M, Dunn D, Ebersol AK, Frum T, Giste E, Johnson AK, Johnson EM, Kutyavin T, Lajoie B, Lee B-K, Lee K, London D, Lotakis D, Neph S, Neri F, Nguyen ED, Qu H, Reynolds AP, Roach V, Safi A, Sanchez ME, Sanyal A, Shafer A, Simon JM, Song L, Vong S, Weaver M, Yan Y, Zhang Z, Zhang Z, Lenhard B, Tewari M, Dorschner MO, Hansen RS, Navas PA, Stamatoyannopoulos G, Iyer VR, Lieb JD, Sunyaev SR, Akey JM, Sabo PJ, Kaul R, Furey TS, Dekker J, Crawford GE, Stamatoyannopoulos JAet al., 2012, The accessible chromatin landscape of the human genome, NATURE, Vol: 489, Pages: 75-82, ISSN: 0028-0836

Journal article

Carvalho RH, Haberle V, Hou J, van Gent T, Thongjuea S, van IJcken W, Kockx C, Brouwer R, Rijkers E, Sieuwerts A, Foekens J, van Vroonhoven M, Aerts J, Grosveld F, Lenhard B, Philipsen Set al., 2012, Genome-wide DNA methylation profiling of non-small cell lung carcinomas, EPIGENETICS & CHROMATIN, Vol: 5

Journal article

Sleutels F, Soochit W, Bartkuhn M, Heath H, Dienstbach S, Bergmaier P, Franke V, Rosa-Garrido M, van de Nobelen S, Caesar L, van der Reijden M, Bryne JC, van IJcken W, Grootegoed JA, Delgado MD, Lenhard B, Renkawitz R, Grosveld F, Galjart Net al., 2012, The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner, EPIGENETICS & CHROMATIN, Vol: 5, ISSN: 1756-8935

Journal article

Schroder K, Irvine KM, Taylor MS, Bokil NJ, Cao K-AL, Masterman K-A, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, McLachlan GJ, Goldman N, Grimmond SM, Carninci P, Suzuki H, Hayashizaki Y, Lenhard B, Hume DA, Sweet MJet al., 2012, Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: E944-E953, ISSN: 0027-8424

Journal article

Lenhard B, Sandelin A, Carninci P, 2012, REGULATORY ELEMENTS Metazoan promoters: emerging characteristics and insights into transcriptional regulation, NATURE REVIEWS GENETICS, Vol: 13, Pages: 233-245, ISSN: 1471-0056

Journal article

Plessy C, Pascarella G, Bertin N, Akalin A, Carrieri C, Vassalli A, Lazarevic D, Severin J, Vlachouli C, Simone R, Faulkner GJ, Kawai J, Daub CO, Zucchelli S, Hayashizaki Y, Mombaerts P, Lenhard B, Gustincich S, Carninci Pet al., 2012, Promoter architecture of mouse olfactory receptor genes, GENOME RESEARCH, Vol: 22, Pages: 486-497, ISSN: 1088-9051

Journal article

Stadhouders R, Thongjuea S, Andrieu-Soler C, Palstra R-J, Bryne JC, van den Heuvel A, Stevens M, de Boer E, Kockx C, van der Sloot A, van den Hout M, van IJcken W, Eick D, Lenhard B, Grosveld F, Soler Eet al., 2012, Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development, EMBO JOURNAL, Vol: 31, Pages: 986-999, ISSN: 0261-4189

Journal article

Taniya T, Tanaka S, Yamaguchi-Kabata Y, Hanaoka H, Yamasaki C, Maekawa H, Barrero RA, Lenhard B, Datta MW, Shimoyama M, Bumgarner R, Chakraborty R, Hopkinson I, Jia L, Hide W, Auffray C, Minoshima S, Imanishi T, Gojobori Tet al., 2012, A prioritization analysis of disease association by data-mining of functional annotation of human genes, GENOMICS, Vol: 99, Pages: 1-9, ISSN: 0888-7543

Journal article

Haberle V, Lenhard B, 2012, Dissecting genomic regulatory elements in vivo., Nat Biotechnol, Vol: 30, Pages: 504-506

Journal article

de Almeida CR, Stadhouders R, de Bruijn MJW, Bergen IM, Thongjuea S, Lenhard B, van IJcken W, Grosveld F, Galjart N, Soler E, Hendriks RWet al., 2011, The DNA-Binding Protein CTCF Limits Proximal V kappa Recombination and Restricts kappa Enhancer Interactions to the Immunoglobulin kappa Light Chain Locus, IMMUNITY, Vol: 35, Pages: 501-513, ISSN: 1074-7613

Journal article

Luis Royo J, Hidalgo C, Roncero Y, Angeles Seda M, Akalin A, Lenhard B, Casares F, Luis Gomez-Skarmeta Jet al., 2011, Dissecting the Transcriptional Regulatory Properties of Human Chromosome 16 Highly Conserved Non-Coding Regions, PLOS ONE, Vol: 6, ISSN: 1932-6203

Journal article

Engelen E, Akinci U, Bryne JC, Hou J, Gontan C, Moen M, Szumska D, Kockx C, van IJcken W, Dekkers DHW, Demmers J, Rijkers E-J, Bhattacharya S, Philipsen S, Pevny LH, Grosveld FG, Rottier RJ, Lenhard B, Poot RAet al., 2011, Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes, NATURE GENETICS, Vol: 43, Pages: 607-U153, ISSN: 1061-4036

Journal article

Ragvin A, Moro E, Fredman D, Navratilova P, Drivenes Ø, Engström PG, Alonso ME, Mustienes EDLC, Gómez Skarmeta JL, Tavares MJ, Casares F, Manzanares M, Van Heyningen V, Molven A, Njølstad PR, Argenton F, Lenhard B, Becker TSet al., 2011, Erratum: Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3 (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 2, (775-780) DOI: 10.1073/pnas.0911591107), Proceedings of the National Academy of Sciences of the United States of America, Vol: 108, ISSN: 0027-8424

Journal article

Fredman D, Dong X, Lenhard B, 2011, Making enhancers from spare parts of the genome., Genome Biol, Vol: 12

New studies show that novel long-range enhancers of developmental genes can emerge by exaptation of protein-coding sequences with no previous regulatory function.

Journal article

Denoeud F, Henriet S, Mungpakdee S, Aury J-M, Da Silva C, Brinkmann H, Mikhaleva J, Olsen LC, Jubin C, Canestro C, Bouquet J-M, Danks G, Poulain J, Campsteijn C, Adamski M, Cross I, Yadetie F, Muffato M, Louis A, Butcher S, Tsagkogeorga G, Konrad A, Singh S, Jensen MF, Cong EH, Eikeseth-Otteraa H, Noel B, Anthouard V, Porcel BM, Kachouri-Lafond R, Nishino A, Ugolini M, Chourrout P, Nishida H, Aasland R, Huzurbazar S, Westhof E, Delsuc F, Lehrach H, Reinhardt R, Weissenbach J, Roy SW, Artiguenave F, Postlethwait JH, Manak JR, Thompson EM, Jaillon O, Du Pasquier L, Boudinot P, Liberles DA, Volff J-N, Philippe H, Lenhard B, Roest Crollius H, Wincker P, Chourrout Det al., 2010, Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate, SCIENCE, Vol: 330, Pages: 1381-1385, ISSN: 0036-8075

Journal article

Soler E, Andrieu-Soler C, De Boer E, Bryne JC, Thongjuea S, Stadhouders R, Palstra RJ, Stevens M, Kockx C, Van Ijcken W, Hou J, Steinhoff C, Rijkers E, Lenhard B, Grosveld Fet al., 2010, The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation (Genes & Development (2010) 24, (277-289)), Genes and Development, Vol: 24, ISSN: 0890-9369

Journal article

Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest ARR, Gough J, Grimmond S, Han J-H, Hashimoto T, Hide W, Hofmann O, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, Ogawa C, Teasdale RD, Tegner J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Yet al., 2010, An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man, CELL, Vol: 140, Pages: 744-752, ISSN: 0092-8674

Journal article

Dong X, Navratilova P, Fredman D, Drivenes O, Becker TS, Lenhard Bet al., 2010, Exonic remnants of whole-genome duplication reveal cis-regulatory function of coding exons, NUCLEIC ACIDS RESEARCH, Vol: 38, Pages: 1071-1085, ISSN: 0305-1048

Journal article

Soler E, Andrieu-Soler C, de Boer E, Christian Bryne J, Thongjuea S, Stadhouders R, Palstra R, Stevens M, Kockx C, van IJcken W, Hou J, Steinhoff C, Rijkers E, Lenhard B, Grosveld Fet al., 2010, Erratum: The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation., Genes & development, Vol: 24, Pages: 623-623, ISSN: 0890-9369

Journal article

Soler E, Andrieu-Soler C, de Boer E, Bryne JC, Thongjuea S, Stadhouders R, Palstra R-J, Stevens M, Kockx C, van IJcken W, Hou J, Steinhoff C, Rijkers E, Lenhard B, Grosveld Fet al., 2010, The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation, GENES & DEVELOPMENT, Vol: 24, Pages: 277-289, ISSN: 0890-9369

Journal article

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