Imperial College London


Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology



+44 (0)20 3313 8353b.lenhard Website




Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318




230ICTEM buildingHammersmith Campus






BibTex format

author = {Ferreirós-Vidal, I and Carroll, T and Zhang, T and Lagani, V and Ramirez, RN and Ing-Simmons, E and Garcia, A and Cooper, L and Liang, Z and Papoutsoglou, G and Dharmalingam, G and Guo, Y and Tarazona, S and Fernandes, SJ and Noori, P and SIlberberg, G and Fisher, AG and Tsamardinos, I and Mortazavi, A and Lenhard, B and Conesa, A and Tegner, J and Merkenschlager, M and Gomez-Cabrero, D},
doi = {10.1371/journal.pbio.2006506},
journal = {PLoS Biology},
title = {Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation},
url = {},
volume = {17},
year = {2019}

RIS format (EndNote, RefMan)

AB - The differentiation of self-renewingprogenitor cells requires not only the regulation of lineage-and developmental stage-specific genes, but also the coordinated adaptation of housekeeping functionsfrom a metabolically active, proliferative state towards quiescence. How metabolic and cell cycle states are coordinated with the regulation of cell type-specific genes is an important question, as dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell progenitor differentiation. We find that the coordinated regulation of housekeeping functions and tissue-specific gene expressionrequires afeedforward circuit whereby Ikarosdownregulates the expression of Myc. Our findings show how coordination between differentiation and housekeeping statescan be achieved by interconnected regulators. Similar principles likely coordinate differentiation and housekeeping functions during progenitor cell differentiation in other cell lineages.
AU - Ferreirós-Vidal,I
AU - Carroll,T
AU - Zhang,T
AU - Lagani,V
AU - Ramirez,RN
AU - Ing-Simmons,E
AU - Garcia,A
AU - Cooper,L
AU - Liang,Z
AU - Papoutsoglou,G
AU - Dharmalingam,G
AU - Guo,Y
AU - Tarazona,S
AU - Fernandes,SJ
AU - Noori,P
AU - SIlberberg,G
AU - Fisher,AG
AU - Tsamardinos,I
AU - Mortazavi,A
AU - Lenhard,B
AU - Conesa,A
AU - Tegner,J
AU - Merkenschlager,M
AU - Gomez-Cabrero,D
DO - 10.1371/journal.pbio.2006506
PY - 2019///
SN - 1544-9173
TI - Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation
T2 - PLoS Biology
UR -
UR -
VL - 17
ER -