Imperial College London

ProfessorBorisLenhard

Faculty of MedicineInstitute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 3313 8353b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Lewis:2020:10.1101/2020.01.27.920108,
author = {Lewis, S and Ross, L and Bain, SA and Pahita, E and Smith, SA and Cordaux, R and Miska, EM and Lenhard, B and Jiggins, FM and Sarkies, P},
doi = {10.1101/2020.01.27.920108},
publisher = {Cold Spring Harbor Laboratory},
title = {Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods},
url = {http://dx.doi.org/10.1101/2020.01.27.920108},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - UNPB
AB - <jats:title>Abstract</jats:title><jats:p>Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters of genes. In insects, DNA methylation is generally restricted to a small subset of transcribed genes, with both intergenic regions and transposable elements (TEs) depleted of methylation. The evolutionary origin and the function of these methylation patterns are poorly understood. Here we characterise the evolution of DNA methylation across the arthropod phylum. While the common ancestor of the arthropods had low levels of TE methylation and did not methylate promoters, both of these functions have evolved independently in centipedes and mealybugs. In contrast, methylation of the exons of a subset of transcribed genes is ancestral and widely conserved across the phylum, but has been lost in specific lineages. Remarkably the same set of genes are likely to be methylated in all species that retained exon-enriched methylation. We show that these genes have characteristic patterns of expression correlating to broad transcription initiation sites and well-positioned nucleosomes, providing new insights into potential mechanisms driving methylation patterns over hundreds of millions of years.</jats:p><jats:sec><jats:title>Author Summary</jats:title><jats:p>Animals develop from a single cell to form a complex organism with many specialised cells. Almost all of the fantastic variety of cells must have the same sequence of DNA, and yet they have distinct identities that are preserved even when they divide. This remarkable process is achieved by turning different sets of genes on or off in different types of cell using molecular mechanisms known as “epigenetic gene regulation”.</jats:p><jats:p>Surprisingly, though all animals need epigenetic gene
AU - Lewis,S
AU - Ross,L
AU - Bain,SA
AU - Pahita,E
AU - Smith,SA
AU - Cordaux,R
AU - Miska,EM
AU - Lenhard,B
AU - Jiggins,FM
AU - Sarkies,P
DO - 10.1101/2020.01.27.920108
PB - Cold Spring Harbor Laboratory
PY - 2020///
TI - Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods
UR - http://dx.doi.org/10.1101/2020.01.27.920108
ER -