Imperial College London
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ProfessorBorisLenhard

Faculty of Medicine, Institute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 7594 0911b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

6.12CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Martín-Durán:2020:10.1101/2020.05.07.078311,
author = {Martín-Durán, JM and Vellutini, BC and Marlétaz, F and Cetrangolo, V and Cvetesic, N and Thiel, D and Henriet, S and Grau-Bové, X and Carrillo-Baltodano, AM and Gu, W and Kerbl, A and Marquez, Y and Bekkouche, N and Chourrout, D and Gómez-Skarmeta, JL and Irimia, M and Lenhard, B and Worsaae, K and Hejnol, A},
doi = {10.1101/2020.05.07.078311},
title = {Conservative route to genome compaction in a miniature annelid},
url = {http://dx.doi.org/10.1101/2020.05.07.078311},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - <jats:title>Summary</jats:title><jats:p>The causes and consequences of genome reduction in animals are unclear, because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact 73.8 Mb genome of <jats:italic>Dimorphilus gyrociliatus</jats:italic>, a meiobenthic segmented worm. The <jats:italic>D. gyrociliatus</jats:italic> genome retains traits classically associated with larger and slower-evolving genomes, such as an ordered, intact Hox cluster, a generally conserved developmental toolkit, and traces of ancestral bilaterian linkage. Unlike some other animals with small genomes, the analysis of the <jats:italic>D. gyrociliatus</jats:italic> epigenome revealed canonical features of genome regulation, excluding the presence of operons and <jats:italic>trans</jats:italic>-splicing. Instead, the gene dense <jats:italic>D. gyrociliatus</jats:italic> genome presents a divergent Myc pathway, a key physiological regulator of growth, proliferation, and genome stability in animals. Altogether, our results uncover a conservative route to genome compaction in annelids, reminiscent of that observed in the vertebrate <jats:italic>Takifugu rubripes</jats:italic>.</jats:p>
AU  - Martín-Durán,JM
AU  - Vellutini,BC
AU  - Marlétaz,F
AU  - Cetrangolo,V
AU  - Cvetesic,N
AU  - Thiel,D
AU  - Henriet,S
AU  - Grau-Bové,X
AU  - Carrillo-Baltodano,AM
AU  - Gu,W
AU  - Kerbl,A
AU  - Marquez,Y
AU  - Bekkouche,N
AU  - Chourrout,D
AU  - Gómez-Skarmeta,JL
AU  - Irimia,M
AU  - Lenhard,B
AU  - Worsaae,K
AU  - Hejnol,A
DO  - 10.1101/2020.05.07.078311
PY  - 2020///
TI  - Conservative route to genome compaction in a miniature annelid
UR  - http://dx.doi.org/10.1101/2020.05.07.078311
ER  -
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