Imperial College London
Portrait Picture

ProfessorBorisLenhard

Faculty of Medicine, Institute of Clinical Sciences

Professor of Computational Biology
 
 
 
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Contact

 

+44 (0)20 7594 0911b.lenhard Website

 
 
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Assistant

 

Mr Alastair Douglas Ivor Williams +44 (0)20 3313 4318

 
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Location

 

6.12CLMS BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cheung:2016:10.1016/j.ccell.2015.12.007,
author = {Cheung, N and Fung, TK and Zeisig, BB and Holmes, K and Rane, JK and Mowen, KA and Finn, MG and Lenhard, B and Chan, LC and So, CWE},
doi = {10.1016/j.ccell.2015.12.007},
journal = {Cancer Cell},
pages = {32--48},
title = {Targeting aberrant epigenetic networks mediated by PRMT1 and KDM4C in acute myeloid leukemia},
url = {http://dx.doi.org/10.1016/j.ccell.2015.12.007},
volume = {29},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Transcriptional deregulation plays a major role in acute myeloid leukemia, and therefore identification of epigenetic modifying enzymes essential for the maintenance of oncogenic transcription programs holds the key to better understanding of the biology and designing effective therapeutic strategies for the disease. Here we provide experimental evidence for the functional involvement and therapeutic potential of targeting PRMT1, an H4R3 methyltransferase, in various MLL and non-MLL leukemias. PRMT1 is necessary but not sufficient for leukemic transformation, which requires co-recruitment of KDM4C, an H3K9 demethylase, by chimeric transcription factors to mediate epigenetic reprogramming. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions and MOZ-TIF2, revealing a tractable aberrant epigenetic circuitry mediated by KDM4C and PRMT1 in acute leukemia.
AU  - Cheung,N
AU  - Fung,TK
AU  - Zeisig,BB
AU  - Holmes,K
AU  - Rane,JK
AU  - Mowen,KA
AU  - Finn,MG
AU  - Lenhard,B
AU  - Chan,LC
AU  - So,CWE
DO  - 10.1016/j.ccell.2015.12.007
EP  - 48
PY  - 2016///
SN  - 1878-3686
SP  - 32
TI  - Targeting aberrant epigenetic networks mediated by PRMT1 and KDM4C in acute myeloid leukemia
T2  - Cancer Cell
UR  - http://dx.doi.org/10.1016/j.ccell.2015.12.007
UR  - http://hdl.handle.net/10044/1/32993
VL  - 29
ER  -
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