Imperial College London

Dr Benjamin Mullish

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

NIHR Clinical Lecturer
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

126 results found

Segal J, McLaughlin S, Penez L, Mullish BH, Quraishi M, Ding N, Kandiah K, Samaan M, Irving P, Faiz O, Clark S, Hart Aet al., 2018, P141 Infliximab therapy for inflammatory pouch pathology: a multi-centre retrospective study, 13th Congress of ECCO – European Crohn’s and Colitis Organisation, Publisher: Oxford University Press (OUP), Pages: S167-S167, ISSN: 1873-9946

Conference paper

Ding NS, Mullish BH, McLaughlin J, Hart A, Marchesi JRet al., 2018, Meeting update: faecal microbiota transplantation--bench, bedside, courtroom?, Frontline Gastroenterol, Vol: 9, Pages: 45-48, ISSN: 2041-4137

Journal article

Forlano R, Manousou P, Mullish BH, Olaoke A, Khelifa MZ, Tsipouras MG, Yee M, Taylor-Robinson S, Lloyd J, Goldin RD, Thursz MR, Khan SAet al., 2017, Assessment of non invasive markers of fibrosis against collagen quantitation and NASH-CRN scoring in liver biopsies of NAFLD patients, The AASLD Liver Meeting 2017, Publisher: Wiley, Pages: 334A-334A, ISSN: 0270-9139

Conference paper

Mullish B, Forlano R, Yee M, Giannakeas N, Goldin RD, Taylor-Robinson SD, Khan SA, Thursz MR, Manousou Pet al., 2017, Development of an algorithm for the prediction of cardiovascular events in patients with NAFLD: the role of mean platelet volume, 68th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Publisher: WILEY, Pages: 1175A-1176A, ISSN: 0270-9139

Conference paper

King A, Mullish BH, Williams HRT, Aylin Pet al., 2017, Comparative epidemiology of Clostridium difficile infection: England and the USA, International Journal for Quality in Health Care, Vol: 29, Pages: 785-791, ISSN: 1353-4505

Journal article

Mullish BH, McDonald JAK, Thursz MR, Marchesi JRet al., 2017, Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial., Hepatology, Vol: 66, Pages: 1354-1355

Journal article

Innes AJ, Mullish BH, Fernando F, Adams G, Marchesi JR, Apperley JF, Brannigan E, Davies F, Pavlů Jet al., 2017, Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality., Bone Marrow Transplant, Vol: 52, Pages: 1452-1454

Journal article

Mullish BH, Forlano R, Yee M, Giannakeas N, Goldin R, Taylor-Robinson S, Khan S, Thursz M, Manousou Pet al., 2017, Development Of An Algorithm For The Prediction Of Cardiovascular Events In Patients With NAFLD: The Role Of Mean Platelet Volume., BASL 2017 Annual Meeting

Conference paper

Mullish BH, McDonald JAK, Kao DH, Allegretti JR, Petrof EO, Pechlivanis A, Barker GF, Atkinson SR, Williams HRT, Thursz MR, Marchesi JRet al., 2017, OC-063 Gut microbiota-host bile acid metabolism interactions in clostridium difficile infection: the explanation for the efficacy of faecal microbiota transplantation?, British Society of Gastroenterology Annual Meeting, Publisher: BMJ Publishing Group, Pages: A33-A34, ISSN: 1468-3288

Conference paper

Forlano R, Mullish BH, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Tsipouras MG, Rui F, Khan S, Taylor-Robinson S, Goldin RD, Thursz MR, Manosou Pet al., 2017, PWE-094 The severity of steatosis does not influence liver stiffness measurements in patients with non-alcoholic fatty liver disease, British Society of Gastroenterology Annual Meeting, Publisher: BMJ Publishing Group, Pages: A174-A174, ISSN: 1468-3288

Conference paper

Forlano R, Mullish BH, Maurice J, Angkathunyakul N, Goldin E, Yee M, Serviddio G, Giannakeas N, Tzallas AT, Rui F, Goldin R, Thursz M, Manousou Pet al., 2017, PWE-093 Development and validation of an automated system for assessment of liver steatosis and fibrosis in routine: histological images in patients with non-alcoholic fatty liver disease, British Society of Gastroenterology Annual Meeting, Publisher: BMJ Publishing Group, Pages: A173-A174, ISSN: 1468-3288

Conference paper

Forlano R, Maurice J, Mullish BH, Angkathunyakul N, Goldin E, Serviddio G, Yee M, Giannakeas N, Tzallas AT, Tsipouras MG, Khan S, Taylor-Robinson S, Goldin R, Thursz M, Manousou Pet al., 2017, The severity of steatosis does not influence liver stiffness measurements in patients with Non-Alcoholic Fatty Liver Disease, International Liver Conference, Publisher: Elsevier, Pages: S586-S587, ISSN: 0169-5185

Conference paper

Quraishi MN, Segal J, Mullish B, McCune VL, Hawkey P, Colville A, Williams H, Hart A, Iqbal THet al., 2017, National survey of practice of faecal microbiota transplantation for Clostridium difficile infection in the UK., J Hosp Infect, Vol: 95, Pages: 444-445

Journal article

Mullish BH, McDonald JA, Kao DH, Allegretti JR, Petrof EO, Pechlivanis A, Atkinson SR, Williams HR, Thursz MR, Marchesi Jet al., 2017, Understanding the Mechanisms of Efficacy of Fecal Microbiota Transplantation in the Treatment of Clostridium Difficile Infection: The Potential Role of Bilemetabolising Enzymes, Publisher: Elsevier BV, Pages: S47-S47, ISSN: 0016-5085

Conference paper

Dhar A, Mullish BH, Thursz MR, 2017, Grand round: anticoagulation in chronic liver disease, Journal of Hepatology, Vol: 66, Pages: 1313-1326, ISSN: 1600-0641

In this Grand Round, we first present a case of a man with decompensated liver disease who subsequently developed a fatal pulmonary embolism, having not been prescribed prophylactic anticoagulation to prevent venous thromboembolic disease. We go on to discuss the burden of thrombotic disease in those with chronic liver disease, before a more detailed discussion regarding the current evidence, safety data, and clinical dilemmas regarding the use of anticoagulation in patients with chronic liver disease, as well as discussing potential future directions within this field.

Journal article

Guideline Development Group, 2016, Non-alcoholic fatty liver disease (NAFLD): assessment and management, Non-alcoholic fatty liver disease (NAFLD): assessment and management, NICE Guideline NG49

Report

Quraishi MN, Segal J, Mullish B, McCune V, Hawkey P, Colville A, Williams H, Hart A, Iqbal THet al., 2016, OC-040 National Survey of Practice of Faecal Microbiota Transplantation for Clostridium Difficile Infection in the United Kingdom, Publisher: BMJ, Pages: A23.2-A24, ISSN: 0017-5749

Conference paper

Mullish BH, McDonald JAK, Pechlivanis A, Rees DN, Williams HRT, Marchesi JR, Thursz MRet al., 2016, PWE-094 Understanding The Efficacy of Faecal Microbiota Transplantation in Clostridium Difficile Infection: Re-Establishment of Gut Microbiota with The Ability to Degrade Bile?, Publisher: BMJ, Pages: A184.2-A184, ISSN: 0017-5749

Conference paper

Jones A, Mullish BH, Williams HRT, Aylin Pet al., 2016, Improvements in Clostridium difficile infection in England and comparative epidemiology with the US, 33rd International Society for Quality in Health Care Conference 2016, Publisher: Oxford University Press (OUP), ISSN: 1464-3677

Conference paper

Gratton J, Phetcharaburanin J, Mullish BH, Williams HRT, Thursz M, Nicholson JK, Holmes E, Marchesi JR, Li Jet al., 2016, An optimized sample handling strategy for metabolic profiling of human feces, Analytical Chemistry, Vol: 88, Pages: 4661-4668, ISSN: 0003-2700

Fecal metabolites are being increasingly studied to unravel the host-gut microbial metabolic interactions. However, there are currently no guidelines for fecal sample collection and storage based on a systematic evaluation of the effect of time, storage temperature, storage duration and sampling strategy. Here we derive an optimized protocol for fecal sample handling with the aim of maximizing metabolic stability and minimizing sample degradation. Samples obtained from five healthy individuals were analyzed to assess topographical homogeneity of feces, and to evaluate storage duration-, temperature- and freeze-thaw cycle-induced metabolic changes in crude stool and fecal water using a 1H NMR spectroscopy-based metabolic profiling approach. Inter-individual variation was much greater than that attributable to storage conditions. Individual stool samples were found to be heterogeneous and spot sampling resulted in a high degree of metabolic variation. Crude fecal samples were remarkably unstable over time and exhibited distinct metabolic profiles at different storage temperatures. Microbial fermentation was the dominant driver in time-related changes observed in fecal samples stored at room temperature and this fermentative process was reduced when stored at 4°C. Crude fecal samples frozen at -20°C manifested elevated amino acids and nicotinate and depleted short chain fatty acids compared to crude fecal control samples. The relative concentrations of branched-chain and aromatic amino acids significantly increased in the freeze-thawed crude fecal samples, suggesting a release of microbial intracellular contents. The metabolic profiles of fecal water samples were more stable compared to crude samples. Our recommendation is that intact fecal samples should be collected, kept at 4°C or on ice during transportation, and extracted ideally within 1 h of collection, or a maximum of 24 h. Fecal water samples should be extracted from a representative amount (~15 g)

Journal article

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Neurology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 237-237, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Nephrology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 271-271, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Psychiatry, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 313-313, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Clinical sciences, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 95-95, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Geriatric medicine, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 169-169, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Rheumatology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 357-357, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Ophthalmology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 303-303, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Endocrinology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 143-143, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Clinical haematology and oncology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 27-27, ISBN: 9781909836426

Book chapter

Mannan I, Cheung V, Grout C, Mullish B, Dias Aet al., 2016, Cardiology, MRCP Part 1: 400 BOFs, Publisher: Jaypee Brothers Medical Publishers (P) Ltd., Pages: 1-1, ISBN: 9781909836426

Book chapter

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