Imperial College London

Dr Benjamin Mullish

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

NIHR Clinical Lecturer
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Segal:2019:10.1177/1756284818822250,
author = {Segal, JP and Mullish, B and Quraishi, MN and Acharjee, A and Williams, HRT and Iqbal, T and Hart, A and Marchesi, JR},
doi = {10.1177/1756284818822250},
journal = {Therapeutic Advances in Gastroenterology},
pages = {1--13},
title = {The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease},
url = {http://dx.doi.org/10.1177/1756284818822250},
volume = {12},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - The aetiopathogenesis of inflammatory bowel diseases (IBD) involves the complex interaction between a patient’s genetic predisposition, environment, gut microbiota and immune system. Currently, however, it is not known if the distinctive perturbations of the gut microbiota that appear to accompany both Crohn’s disease and ulcerative colitis are the cause of, or the result of, the intestinal inflammation that characterizes IBD.With the utilization of novel systems biology technologies, we can now begin to understand not only details about compositional changes in the gut microbiota in IBD, but increasingly also the alterations in microbiota function that accompany these. Technologies such as metagenomics, metataxomics, metatranscriptomics, metaproteomics and metabonomics are therefore allowing us a deeper understanding of the role of the microbiota in IBD. Furthermore, the integration of these systems biology technologies through advancing computational and statistical techniques are beginning to understand the microbiome interactions that both contribute to health and diseased states in IBD.This review aims to explore how such systems biology technologies are advancing our understanding of the gut microbiota, and their potential role in delineating the aetiology, development and clinical care of IBD.
AU - Segal,JP
AU - Mullish,B
AU - Quraishi,MN
AU - Acharjee,A
AU - Williams,HRT
AU - Iqbal,T
AU - Hart,A
AU - Marchesi,JR
DO - 10.1177/1756284818822250
EP - 13
PY - 2019///
SN - 1756-2848
SP - 1
TI - The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease
T2 - Therapeutic Advances in Gastroenterology
UR - http://dx.doi.org/10.1177/1756284818822250
UR - http://hdl.handle.net/10044/1/66503
VL - 12
ER -