Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Allegretti:2019:10.14309/01.ajg.0000592884.95396.04,
author = {Allegretti, JR and Mullish, B and Hurtado, J and Carrellas, M and Marcus, J and Phelps, E and Pettee, W and Marchesi, J and McDonald, JAK and Barker, G and Blanco, JM and Garcia, Perez I and Kelly, CR and Grinspan, A and Fischer, M},
doi = {10.14309/01.ajg.0000592884.95396.04},
journal = {American Journal of Gastroenterology},
pages = {S484--S485},
title = {837 Short Chain Fatty Acid Profiles Are Altered by Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease and Recurrent Clostridioides difficile Infection},
url = {http://dx.doi.org/10.14309/01.ajg.0000592884.95396.04},
volume = {114},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:sec>            <jats:title>INTRODUCTION:</jats:title>            <jats:p>Recurrent <jats:italic toggle="yes">C. difficile</jats:italic> infection (rCDI) is a major challenge among patients with inflammatory bowel disease (IBD). Perturbation of microbiota-mediated metabolism of short chain fatty acids (SCFA) has been reported in IBD patients. Fecal microbiota transplantation (FMT), an established therapy for rCDI, alters gut microbiota composition, but effects on SCFA are unclear. Accordingly, this study assessed SCFA profiles in IBD patients with rCDI pre- and post-FMT.</jats:p>          </jats:sec>          <jats:sec>            <jats:title>METHODS:</jats:title>            <jats:p>This open-label, prospective, single-arm multi-center cohort study enrolled patients from 4 tertiary care centers. Patients with IBD and ≥2 episodes of CDI received a single colonoscopic FMT from a universal stool bank. The primary outcome was CDI recurrence up to week 8 defined as diarrhea and EIA-positive toxin testing for <jats:italic toggle="yes">C. difficile</jats:italic>. Stool for metabolomic profiling was collected pre-FMT and week 1, 8 and 12 weeks post-FMT. A targeted gas chromatography-mass spectrometry protocol was used for the identification and quantification of SCFA. SCFA concentrations were analyzed via univariate analysis, comparing groups (e.g. pre- <jats:italic toggle="yes">vs</jats:italic> post-FMT).</jats:p>          </jats:sec>          <jats:sec>            <jats:title>RESULTS:</jats:title>            <jats:p>37 participants were enrolled, with mean age of 37.6 years (range 20-76) and primarily female (n = 21, 57%). 14 had Crohn’s disease (CD) (mean HBI = 6.4) and 23 had ulcerative colitis (UC) (mean Partial Mayo Score = 4.5). Mean baseline fecal calprotectin was 1804.8 +/- 2307.7 Overall, 3
AU  - Allegretti,JR
AU  - Mullish,B
AU  - Hurtado,J
AU  - Carrellas,M
AU  - Marcus,J
AU  - Phelps,E
AU  - Pettee,W
AU  - Marchesi,J
AU  - McDonald,JAK
AU  - Barker,G
AU  - Blanco,JM
AU  - Garcia,Perez I
AU  - Kelly,CR
AU  - Grinspan,A
AU  - Fischer,M
DO  - 10.14309/01.ajg.0000592884.95396.04
EP  - 485
PY  - 2019///
SN  - 0002-9270
SP  - 484
TI  - 837 Short Chain Fatty Acid Profiles Are Altered by Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease and Recurrent Clostridioides difficile Infection
T2  - American Journal of Gastroenterology
UR  - http://dx.doi.org/10.14309/01.ajg.0000592884.95396.04
UR  - http://hdl.handle.net/10044/1/73853
VL  - 114
ER  -
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