Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ghani:2020:10.1099/acmi.fis2019.po0047,
author = {Ghani, R and Mullish, B and Thursz, M and Marchesi, J and Ghazy, A and Davies, F},
doi = {10.1099/acmi.fis2019.po0047},
journal = {Access Microbiology},
title = {Case-control study of recurrent Extended-Spectrum Beta Lactamase Enterobacteriaceae Urinary Tract Infections (ESBL UTIs): the management challenges},
url = {http://dx.doi.org/10.1099/acmi.fis2019.po0047},
volume = {2},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Recurrent UTIs are associated with increased hospitalisation and antibiotic use. We investigated patients with recurrent ESBL versus non-ESBL UTIs to identify risk factors and potential treatments.</jats:p>               <jats:p>A30 month retrospective case-control study was performed in patients with recurrent EBSL versus non-ESBL UTI. Definition :1) > three in a year (>two weeks apart) or 2) > two in six months (>one week apart) with the same profile. 3) ESBL UTIs were Enterobacteriaceae resistant to cefalexin AND ceftazadime/ceftriaxone.</jats:p>               <jats:p>281/1449 “recurrent UTI” patients were ESBLs. Patients were more likely to be older, male, with associated bacteraemia, colonisation with carbapenemase-producing Enterobacteriaceae (CPE) and higher resistance rates to non beta-lactam antibiotics. 75% of renal patients were transplant cases, 81% of urology patients had a tube insertion.</jats:p>               <jats:p>Recurrent ESBL UTIRecurrent non-ESBL UTIp value</jats:p>               <jats:p>Number (%)Number (%)(Chi-squared test)</jats:p>               <jats:p>Patients  281   1168</jats:p>               <jats:p>Organism  Klebsiella spp (%)42 (14.9) 10 (0.8)  <0.001</jats:p>               <jats:p>E coli (%)199 (70.8)811 (69.4)0.665</jats:p>               <jats:p>Demographics  Age (mean, SD)64.1, 19  58.7, 22  <0.001</jats:p>               <jats:p>Male  137 (48.8)328 (28)  <0.001</jats:p>               <jats:p>Associations  Gram negative bacteraemia 35 (12.4) 37 (3.1)  0.001</jats:p>               <jats:p>Colonisation with CPE 21 (7.5)  31 (2.7)  <0.001</jats:p>               <jats:p>Speciality Renal 84 (30.0) 196 (16.8)<0.001</jats:p>               <jats:p>Urology   47 (16.7) 104 (8.9) <0.001</jats
AU  - Ghani,R
AU  - Mullish,B
AU  - Thursz,M
AU  - Marchesi,J
AU  - Ghazy,A
AU  - Davies,F
DO  - 10.1099/acmi.fis2019.po0047
PY  - 2020///
TI  - Case-control study of recurrent Extended-Spectrum Beta Lactamase Enterobacteriaceae Urinary Tract Infections (ESBL UTIs): the management challenges
T2  - Access Microbiology
UR  - http://dx.doi.org/10.1099/acmi.fis2019.po0047
VL  - 2
ER  -
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