Imperial College London
Portrait Picture

Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
//

Contact

 

b.mullish

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ghani:2020:10.1099/acmi.fis2019.po0048,
author = {Ghani, R and Mullish, B and Mcdonald, J and Williams, H and Gilchrist, M and Brannigan, E and Satta, G and Taube, D and Duncan, N and Pavlu, J and Ghazy, A and Thursz, M and Davies, F and Marchesi, J},
doi = {10.1099/acmi.fis2019.po0048},
journal = {Access Microbiology},
title = {Cohort study of Faecal Microbiota Transplantation for patient’s colonised with MDROs - successful prevention of invasive disease despite low decolonisation rates},
url = {http://dx.doi.org/10.1099/acmi.fis2019.po0048},
volume = {2},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:p>Faecal Microbiota Transplantation (FMT) is widely utilised for recurrent <jats:italic>Clostridioides difficile</jats:italic> infection. Use of FMT for the intestinal eradication of multidrug-resistant organisms (MDROs) has been described in the literature with decolonisation rates from 37.5% to 87.5%. We perform FMT via naso-gastric tube using donor stool prepared anaerobically, using prevention of invasive disease as an endpoint.</jats:p>               <jats:p>FMT was considered for either; 1) Patients who were colonised with >1 MDRO (carbapenem-resistant Enterobacteriaceae, vancomycin resistant Enterococci or extended-spectrum beta lactamase (ESBL) and at risk of invasive MDRO disease or 2) patients who had recurrent MDRO-mediated invasive disease.</jats:p>               <jats:p>Sixteen MDRO colonised/infected patients underwent FMT. Nine patients had a haematological disorder. Eight of these patients had had prolonged admissions (range 6-20 weeks) complicated by septic episodes (5/9 had a MDR bacteraemia) pre-FMT. Post FMT all patients had shorter admissions including five who received higher intensity immunosuppression. Only 1/9 developed MDRO-mediated invasive disease.</jats:p>               <jats:p>Seven FMT patients had recurrent ESBL urinary tract infections (UTIs). 4/7 were renal transplant patients. Following FMT the 3 non-transplant patients had no further UTIs up to six month period. Four transplant patients had reduced number of infections, admissions and use of antibiotics.</jats:p>               <jats:p>5/13 (39%) patients were not MDRO colonised on rectal screens post-FMT (follow up range 12 weeks – 24 months).</jats:p>               <jats:p>Although decolonisation rates were low, patient outcomes post-FMT were apparently improved. Mechanisms of FMT have not fully been established, improvement of colonisation resistance by restoration of microbiota comp
AU  - Ghani,R
AU  - Mullish,B
AU  - Mcdonald,J
AU  - Williams,H
AU  - Gilchrist,M
AU  - Brannigan,E
AU  - Satta,G
AU  - Taube,D
AU  - Duncan,N
AU  - Pavlu,J
AU  - Ghazy,A
AU  - Thursz,M
AU  - Davies,F
AU  - Marchesi,J
DO  - 10.1099/acmi.fis2019.po0048
PY  - 2020///
TI  - Cohort study of Faecal Microbiota Transplantation for patient’s colonised with MDROs - successful prevention of invasive disease despite low decolonisation rates
T2  - Access Microbiology
UR  - http://dx.doi.org/10.1099/acmi.fis2019.po0048
VL  - 2
ER  -
Download