Imperial College London
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Dr Benjamin Mullish

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

IPPRF Research Fellow
 
 
 
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Contact

 

b.mullish

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Forlano:2020:10.1371/journal.pone.0240400,
author = {Forlano, R and Mullish, BH and Mukherjee, SK and Nathwani, R and Harlow, C and Crook, P and Judge, R and Soubieres, A and Middleton, P and Daunt, A and Perez-Guzman, P and Selvapatt, N and Lemoine, M and Dhar, A and Thursz, MR and Nayagam, S and Manousou, P},
doi = {10.1371/journal.pone.0240400},
journal = {PLoS One},
title = {In-hospital mortality is associated with inflammatory response in NAFLD patients admitted for COVID-19},
url = {http://dx.doi.org/10.1371/journal.pone.0240400},
volume = {15},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background & aimsAlthough metabolic risk factors are associated with more severe COVID-19, there is little evidence on outcomes in patients with non-alcoholic fatty liver disease (NAFLD). We here describe the clinical characteristics and outcomes of NAFLD patients in a cohort hospitalised for COVID-19.MethodsThis study included all consecutive patients admitted for COVID-19 between February and April 2020 at Imperial College Healthcare NHS Trust, with either imaging of the liver available dated within one year from the admission or a known diagnosis of NAFLD. Clinical data and early weaning score (EWS) were recorded. NAFLD diagnosis was based on imaging or past medical history and patients were stratified for Fibrosis-4 (FIB-4) index. Clinical endpoints were admission to intensive care unit (ICU)and in-hospital mortality.Results561 patients were admitted. Overall, 193 patients were included in the study. Fifty nine patients (30%) died, 9 (5%) were still in hospital, and 125 (65%) were discharged. The NAFLD cohort (n = 61) was significantly younger (60 vs 70.5 years, p = 0.046) at presentation compared to the non-NAFLD (n = 132). NAFLD diagnosis was not associated with adverse outcomes. However, the NAFLD group had higher C reactive protein (CRP) (107 vs 91.2 mg/L, p = 0.05) compared to non-NAFLD(n = 132). Among NAFLD patients, male gender (p = 0.01), ferritin (p = 0.003) and EWS (p = 0.047) were associated with in-hospital mortality, while the presence of intermediate/high risk FIB-4 or liver cirrhosis was not.ConclusionThe presence of NAFLD per se was not associated with worse outcomes in patients hospitalised for COVID-19. Though NAFLD patients were younger on admission, disease stage was not associated with clinical outcomes. Yet, mortality was associated with gender and a pronounced inflammatory response in the NAFLD group.
AU  - Forlano,R
AU  - Mullish,BH
AU  - Mukherjee,SK
AU  - Nathwani,R
AU  - Harlow,C
AU  - Crook,P
AU  - Judge,R
AU  - Soubieres,A
AU  - Middleton,P
AU  - Daunt,A
AU  - Perez-Guzman,P
AU  - Selvapatt,N
AU  - Lemoine,M
AU  - Dhar,A
AU  - Thursz,MR
AU  - Nayagam,S
AU  - Manousou,P
DO  - 10.1371/journal.pone.0240400
PY  - 2020///
SN  - 1932-6203
TI  - In-hospital mortality is associated with inflammatory response in NAFLD patients admitted for COVID-19
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0240400
UR  - http://hdl.handle.net/10044/1/83363
VL  - 15
ER  -
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