Imperial College London
Alternate

DrBrianRobertson

Faculty of Medicine, Department of Infectious Disease

Reader in Systems Microbiology
 
 
 
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Contact

 

b.robertson

 
 
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Location

 

3.41Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Arthur:2019:10.3390/antibiotics8010004,
author = {Arthur, PK and Amarh, V and Cramer, P and Arkaifie, GB and Blessie, EJS and Fuseini, M-S and Carilo, I and Yeboah, R and Asare, L and Robertson, BD},
doi = {10.3390/antibiotics8010004},
journal = {Antibiotics},
title = {Characterization of two new multidrug-resistant strains of mycobacterium smegmatis: tools for routine in vitro screening of novel anti-mycobacterial agents},
url = {http://dx.doi.org/10.3390/antibiotics8010004},
volume = {8},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mycobacterium tuberculosis is a pathogen of global public health concern. This threat is exacerbated by the emergence of multidrug-resistant and extremely-drug-resistant strains of the pathogen. We have obtained two distinct clones of multidrug-resistant Mycobacterium smegmatis after gradual exposure of Mycobacterium smegmatis mc² 155 to increasing concentrations of erythromycin. The resulting resistant strains of Mycobacterium smegmatis exhibited robust viability in the presence of high concentrations of erythromycin and were found to be resistant to a wide range of other antimicrobials. They also displayed a unique growth phenotype in comparison to the parental drug-susceptible Mycobacterium smegmatis mc² 155, and a distinct colony morphology in the presence of cholesterol. We propose that these two multidrug-resistant clones of Mycobacterium smegmatis could be used as model organisms at the inceptive phase of routine in vitro screening of novel antimicrobial agents targeted against multidrug-resistant Mycobacterial tuberculosis.
AU  - Arthur,PK
AU  - Amarh,V
AU  - Cramer,P
AU  - Arkaifie,GB
AU  - Blessie,EJS
AU  - Fuseini,M-S
AU  - Carilo,I
AU  - Yeboah,R
AU  - Asare,L
AU  - Robertson,BD
DO  - 10.3390/antibiotics8010004
PY  - 2019///
SN  - 2079-6382
TI  - Characterization of two new multidrug-resistant strains of mycobacterium smegmatis: tools for routine in vitro screening of novel anti-mycobacterial agents
T2  - Antibiotics
UR  - http://dx.doi.org/10.3390/antibiotics8010004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30609766
UR  - http://hdl.handle.net/10044/1/67471
VL  - 8
ER  -
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