Imperial College London

DrBarrySeemungal

Faculty of MedicineDepartment of Medicine

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 3311 7712b.seemungal

 
 
//

Assistant

 

Miss Lorna Stevenson +44 (0)20 3313 5525

 
//

Location

 

10L16 ()Lab BlockCharing Cross Campus

//

Summary

 

Publications

Publication Type
Year
to

83 results found

Patel M, Agarwal K, Arshad Q, Hariri M, Rea P, Seemungal BM, Golding JF, Harcourt JP, Bronstein AMet al., Intratympanic steroids vs. gentamicin in unilateral Ménière's disease: a randomised double-blind comparative effectiveness trial, Lancet, ISSN: 1474-547X

Background: Ménière’s disease (MD) is characterised by severe vertigo attacks and deafness. Intratympanic gentamicin ablates vestibular function, quells vertigo and is the standard treatment for refractory MD - but it can worsen hearing. Intratympanic corticosteroids may reduce vertigo without harming hearing but no RCT comparing steroids versus gentamicin is available.Methods: In this comparative effectiveness trial, refractory unilateral MD patients, defined according to the American Academy of Otolaryngology, were double-blindly randomised (1:1 block-design) to intratympanic methylprednisolone (n=30, 62·5mg/ml) or gentamicin (n=30, 40mg/ml) and followed-up over two years at Charing Cross Hospital (Imperial NHS, London) and Leicester Royal Infirmary, Leicester, UK. Primary outcome was vertigo frequency over the final 6-months (18-24months post-injection) compared to a 6-month pre-injection baseline. Secondary outcomes were vestibular and auditory symptoms (validated questionnaires) and hearing preservation (audiometry). ClinicalTrials.gov:NCT00802529.Findings: For intention-to-treat analysis i.e., all 60 patients, number of vertigo attacks/6months (primary outcome) fell from 19·9 to 2·5 [87%] in the gentamicin arm and 16·4 to 1·6 [90%] in the steroid arm (difference in absolute number of attacks in the final 6months -0·9; 95%CI -3·4 to 1·6). Both drugs reduced the number of vertigo attacks at 2 years (P<0·0001), with equal efficacy (P=0·51). For hearing preservation (secondary outcome), there was no difference (P=0·18) between drugs for hearing thresholds (final difference -2·45decibels, 95%CI -13·4 to 8·5). Both drugs reduced auditory and vestibular symptoms equally. As protocol, patients whose vertigo did not respond post-injection (‘non-responders’) were considered for additional injections by an unblinded physician (8 patients ge

JOURNAL ARTICLE

Arshad Q, Roberts RE, Ahmad H, Lobo R, Patel M, Ham T, Sharp DJ, Seemungal BMet al., 2017, Patients with chronic dizziness following traumatic head injury typically have multiple diagnoses involving combined peripheral and central vestibular dysfunction, CLINICAL NEUROLOGY AND NEUROSURGERY, Vol: 155, Pages: 17-19, ISSN: 0303-8467

JOURNAL ARTICLE

Cousins S, Kaski D, Cutfield N, Arshad Q, Ahmad H, Gresty MA, Seemungal BM, Golding J, Bronstein AMet al., 2017, Predictors of clinical recovery from vestibular neuritis: a prospective study, ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, Vol: 4, Pages: 340-346, ISSN: 2328-9503

JOURNAL ARTICLE

Roberts RE, Ahmad H, Arshad Q, Patel M, Dima D, Leech R, Seemungal BM, Sharp DJ, Bronstein AMet al., 2017, Functional neuroimaging of visuo-vestibular interaction., Brain Struct Funct, Vol: 222, Pages: 2329-2343

The brain combines visual, vestibular and proprioceptive information to distinguish between self- and world motion. Often these signals are complementary and indicate that the individual is moving or stationary with respect to the surroundings. However, conflicting visual motion and vestibular cues can lead to ambiguous or false sensations of motion. In this study, we used functional magnetic resonance imaging to explore human brain activation when visual and vestibular cues were either complementary or in conflict. We combined a horizontally moving optokinetic stimulus with caloric irrigation of the right ear to produce conditions where the vestibular activation and visual motion indicated the same (congruent) or opposite directions of self-motion (incongruent). Visuo-vestibular conflict was associated with increased activation in a network of brain regions including posterior insular and transverse temporal areas, cerebellar tonsil, cingulate and medial frontal gyri. In the congruent condition, there was increased activation in primary and secondary visual cortex. These findings suggest that when sensory information regarding self-motion is contradictory, there is preferential activation of multisensory vestibular areas to resolve this ambiguity. When cues are congruent, there is a bias towards visual cortical activation. The data support the view that a network of brain areas including the posterior insular cortex may play an important role in integrating and disambiguating visual and vestibular cues.

JOURNAL ARTICLE

Arshad Q, Seemungal BM, 2016, Age-Related Vestibular Loss: Current Understanding and Future Research Directions, FRONTIERS IN NEUROLOGY, Vol: 7, ISSN: 1664-2295

JOURNAL ARTICLE

Braga RM, Fu RZ, Seemungal BM, Wise RJS, Leech Ret al., 2016, Eye Movements during Auditory Attention Predict Individual Differences in Dorsal Attention Network Activity, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 10, ISSN: 1662-5161

JOURNAL ARTICLE

Kaski D, Quadir S, Nigmatullina Y, Malhotra PA, Bronstein AM, Seemungal BMet al., 2016, Temporoparietal encoding of space and time during vestibular-guided orientation, BRAIN, Vol: 139, Pages: 392-403, ISSN: 0006-8950

JOURNAL ARTICLE

Murdin L, Seemungal BM, Bronstein AM, 2016, Dizziness, Medicine (United Kingdom), Vol: 44, Pages: 484-487, ISSN: 1357-3039

JOURNAL ARTICLE

Patel M, Agarwal K, Arshad Q, Hariri M, Rea P, Seemungal BM, Golding JF, Harcourt JP, Bronstein AMet al., 2016, Intratympanic methylprednisolone versus gentamicin in patients with unilateral Meniere's disease: a randomised, double-blind, comparative effectiveness trial, LANCET, Vol: 388, Pages: 2753-2762, ISSN: 0140-6736

JOURNAL ARTICLE

Seemungal BM, 2016, Screening for BPPV in falls: an easy but big clinical "win", BMJ-BRITISH MEDICAL JOURNAL, Vol: 353, ISSN: 1756-1833

JOURNAL ARTICLE

Yousif N, Bhatt H, Bain PG, Nandi D, Seemungal BMet al., 2016, The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 23, Pages: 668-670, ISSN: 1351-5101

JOURNAL ARTICLE

Yousif N, Fu RZ, Bourquin BA-E-E, Bhrugubanda V, Schultz SR, Seemungal BMet al., 2016, Dopamine Activation Preserves Visual Motion Perception Despite Noise Interference of Human V5/MT, JOURNAL OF NEUROSCIENCE, Vol: 36, Pages: 9303-9312, ISSN: 0270-6474

JOURNAL ARTICLE

Cousins S, Kaski D, Cutfield N, Ahmad H, Arshad Q, Seemungal B, Golding J, Gresty M, Bronstein Aet al., 2015, Clinical recovery after acute vestibular neuritis, 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY-BLACKWELL, Pages: 364-364, ISSN: 1351-5101

CONFERENCE PAPER

Li L, Leech R, Seemungal B, Malhotra P, Sharp Det al., 2015, A SENSE OF DIRECTION: BRAIN STIMULATION IN LATERALISED BRAIN FUNCTION, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Vol: 86, ISSN: 0022-3050

JOURNAL ARTICLE

Li LM, Leech R, Scott G, Malhotra P, Seemungal B, Sharp DJet al., 2015, The effect of oppositional parietal transcranial direct current stimulation on lateralized brain functions, EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 42, Pages: 2904-2914, ISSN: 0953-816X

JOURNAL ARTICLE

Nigmatullina Y, Arshad Q, Wu K, Seemungal BM, Bronstein AM, Soto Det al., 2015, HOW IMAGERY CHANGES SELF-MOTION PERCEPTION, NEUROSCIENCE, Vol: 291, Pages: 46-52, ISSN: 0306-4522

JOURNAL ARTICLE

Nigmatullina Y, Hellyer PJ, Nachev P, Sharp DJ, Seemungal BMet al., 2015, The Neuroanatomical Correlates of Training-Related Perceptuo-Reflex Uncoupling in Dancers, CEREBRAL CORTEX, Vol: 25, Pages: 554-562, ISSN: 1047-3211

JOURNAL ARTICLE

Seemungal B, Kaski D, Antonio Lopez-Escamez J, 2015, Early Diagnosis and Management of Acute Vertigo from Vestibular Migraine and Meniere's Disease, NEUROLOGIC CLINICS, Vol: 33, Pages: 619-+, ISSN: 0733-8619

JOURNAL ARTICLE

Seemungal BM, 2015, The Components of Vestibular Cognition-Motion Versus Spatial Perception, MULTISENSORY RESEARCH, Vol: 28, Pages: 507-524, ISSN: 2213-4794

JOURNAL ARTICLE

Seemungal BM, Arshad Q, Paine H, Milburn J, Wolstenholme S, Collins K, Marcus HJ, Wilson Met al., 2015, What is post-concussion dizziness? Expert neuro-otological assessment in acute Traumatic Brain Injury (TBI), 1st Congress of the European-Academy-of-Neurology, Publisher: WILEY-BLACKWELL, Pages: 52-52, ISSN: 1351-5101

CONFERENCE PAPER

Cousins S, Cutfield NJ, Kaski D, Palla A, Seemungal BM, Golding JF, Staab JP, Bronstein AMet al., 2014, Visual Dependency and Dizziness after Vestibular Neuritis, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Kaski D, Quadir S, Nigmatullina Y, Malhotra P, Bronstein AM, Seemungal BMet al., 2014, Human angular path integration, timing and temporoparietal junction, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 283-283, ISSN: 1351-5101

CONFERENCE PAPER

Kaski D, Quadir S, Nigmatullina Y, Malhotra P, Bronstein AM, Seemungal BMet al., 2014, Human angular path integration, timing and the temporoparietal junction, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S194-S194, ISSN: 0340-5354

CONFERENCE PAPER

Kaski DM, Tahtis VM, Seemungal BM, 2014, The effect of single session bi-cephalic transcranial direct current stimulation on gait performance in sub-acute stroke, EUROPEAN JOURNAL OF NEUROLOGY, Vol: 21, Pages: 239-239, ISSN: 1351-5101

JOURNAL ARTICLE

Kaski DM, Tahtis VM, Seemungal BM, 2014, The effect of single session bi-cephalic transcranial direct current stimulation on gait performance in subacute stroke, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S165-S165, ISSN: 0340-5354

CONFERENCE PAPER

Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker Det al., 2014, Vestibular migraine: Diagnostic criteria. Consensus document of the Barany Society and the International headache society, REVUE NEUROLOGIQUE, Vol: 170, Pages: 401-406, ISSN: 0035-3787

JOURNAL ARTICLE

Nada Y, Hetvi B, Bain P, Nandi D, Seemungal BMet al., 2014, Pedunculopontine nucleus DBS modulates visual-vestibular integration, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 280-280, ISSN: 1351-5101

CONFERENCE PAPER

Nada Y, Hetvi B, Bain P, Nandi D, Seemungal BMet al., 2014, Pedunculopontine nucleus DBS modulates visual-vestibular integration, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S192-S192, ISSN: 0340-5354

CONFERENCE PAPER

Nigmatullina Y, Ferguson V, Yousif N, Seemungal BMet al., 2014, The cortical mechanisms of oscillopsia and its suppression in asymptomatic infantile nystagmus and symptomatic nystagmus in neurological patients, Joint Congress of European Neurology, Publisher: WILEY-BLACKWELL, Pages: 74-74, ISSN: 1351-5101

CONFERENCE PAPER

Nigmatullina Y, Ferguson V, Yousif N, Seemungal BMet al., 2014, The cortical mechanisms of oscillopsia and its suppression in asymptomatic infantile nystagmus and symptomatic nystagmus in neurological patients, Joint Congress of European Neurology, Publisher: SPRINGER HEIDELBERG, Pages: S55-S55, ISSN: 0340-5354

CONFERENCE PAPER

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00341396&limit=30&person=true