Dr Brijesh Patel graduated with double distinction honours from University College London Medical School where he was also awarded a Sir Edward Meyerstein Foundation Scholarship for best aggregate performance during basic medical sciences (years 1 and 2). He initially trained in general internal medicine at the former Royal Postgraduate Medical School (Hammersmith Hospital) attaining MRCP during this time. He subsequently pursued Senior House Officer training in Anaesthesia and Intensive Care Medicine, through Guy’s and St Thomas’ Hospitals.
He was appointed as one of the first NIHR ‘Walport’ Academic Clinical Fellows within the Imperial School of Anaesthesia. During this time he successfully attained a prestigious Wellcome Trust Clinical Research Training Fellowship to undertake a PhD within the department at Imperial College London. He also co-founded a forum (www.periopresearch.com) to support research training within anaesthesia, pain, perioperative, and intensive care medicine. This led to the development of a Pan-London initiative to support academic training within these specialties within London.
His PhD investigated the role of tumour necrosis factor (TNF), long implicated in acute lung injury pathogenesis, and discovered that TNF-signalling triggers alveolar epithelial dysfunction in experimental lung injury through activation of death signals. He held the prestigious Gold Medal for Research from the Intensive Care Society (UK) in 2011/12 for research undertaken during his PhD studies. He was also awarded institutional and regional prizes for his research.
Having completed his PhD, he went on to complete advanced training in Intensive Care Medicine through the Royal Brompton and King’s College Hospitals. He is as an honorary fellow within the severe respiratory failure and ECMO service at the Royal Brompton Hospital. In 2014, he was appointed as a NIHR Clinical Lecturer in Anaesthesia and Intensive Care. His current research focuses on the pathophysiology and basic mechanisms of organ injury and inflammation within critical care disease states, including the optimisation and improvement of translational disease models of critical illness.
He is an invited reviewer for grant bodies including the Medical Research Council as well as journals including Critical Care Medicine, Intensive Care Medicine – Experimental, and American Journal of Physiology: Lung Cell and Molecular Biology. Most recently, he was awarded a Starter Grant for Clinical Lecturers from the Academy of Medical Sciences, as well as BJA/RCoA project grants from the National Institute of Academic Anaesthesia. He is also an elected member of the NEXT and Communications committees of the European Society of Intensive Care Medicine. He is responsible for the article reviews for the society.
- Apoptosis and survival mechanisms within the lung injury and inflammation, in particular, ARDS and primary graft dysfunction post-lung transplantation.
- The roles of leukocytes during the resolution of injury and inflammation in ARDS.
- The mechanisms of alveolar epithelial dysfunction and development of alveolar oedema.
- Translational modelling of critical illness.
- Muscle wasting in critical illness.
et al., 2015, In vivo compartmental analysis of leukocytes in mouse lungs, American Journal of Physiology-lung Cellular and Molecular Physiology, Vol:309, ISSN:1522-1504, Pages:L639-L652
et al., 2013, TNF-Induced Death Signaling Triggers Alveolar Epithelial Dysfunction in Acute Lung Injury, Journal of Immunology, Vol:190, ISSN:0022-1767, Pages:4274-4282
Wilson MR, Patel BV, Takata M, 2012, Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice, Critical Care Medicine, Vol:40, ISSN:0090-3493, Pages:2850-2857
Patel BV, Wilson MR, Takata M, 2012, Resolution of acute lung injury and inflammation: a translational mouse model, European Respiratory Journal, Vol:39, ISSN:0903-1936, Pages:1162-1170
et al., 2011, Sources of alveolar soluble TNF receptors during acute lung injury of different etiologies, Journal of Applied Physiology, Vol:111, ISSN:8750-7587, Pages:177-184