Dr Brijesh Patel graduated with distinction honours from University College London Medical School where he was also awarded a Sir Edward Meyerstein Foundation Scholarship for best aggregate performance during basic medical sciences (years 1 and 2). He initially trained in general internal medicine at the former Royal Postgraduate Medical School (Hammersmith Hospital) attaining MRCP during this time. He subsequently pursued Senior House Officer training in Anaesthesia and Intensive Care Medicine, through Guy’s and St Thomas’ Hospitals.
He was appointed as one of the first NIHR ‘Walport’ Academic Clinical Fellows within the Imperial School of Anaesthesia. During this time he successfully attained a prestigious Wellcome Trust Clinical Research Training Fellowship to undertake a PhD within the department at Imperial College London. His PhD investigated the role of tumour necrosis factor (TNF), long implicated in acute lung injury pathogenesis, and discovered that TNF-signalling triggers alveolar epithelial dysfunction in experimental lung injury through activation of death signals. He held the prestigious Gold Medal for Research from the Intensive Care Society (UK) in 2011/12 for research undertaken during his PhD studies. He was also awarded institutional and regional prizes for his research. Having completed his PhD, he went on to complete advanced training in Intensive Care Medicine through the Royal Brompton and King’s College Hospitals. In 2014, he was appointed as a NIHR Clinical Lecturer in Anaesthesia and Intensive Care.
He is as an honorary consultant at the Royal Brompton & Harefield as well as the Chelsea & Westminster Hospital adult intensive care units. He has clinical interests in cardiorespiratory intensive care and application of extracorporeal life support (ECLS) technologies. He is a member of the ECLS team at Royal Brompton hospital where he leads the ICU research programme.
His current research focuses on the pathophysiology and basic mechanisms of cell death induced organ injury and inflammation within critical care disease states, including ARDS, sepsis and burns. He has particular interests in the optimisation and improvement of translational disease models of critical illness.
He is the an associate editor for the Journal of the Intenisve Care Society (JICS). He is an invited reviewer for grant bodies including the Medical Research Council as well as journals including Critical Care Medicine, Intensive Care Medicine – Experimental, and American Journal of Physiology: Lung Cell and Molecular Biology.
He has been funded by the Academy of Medical Sciences (UK), the National Institute of Academic Anaesthesia, the Euroepan Society of Intensive Care Medicine and industry.
He is also an elected member of the NEXT and Communications committees of the European Society of Intensive Care Medicine. He is responsible for the article reviews for the society.
He is also chairperson for the research subcommittee for the commisioned UK ECMO network for adults with sever respiratory failure.
- Apoptosis and survival mechanisms within the lung injury and inflammation, in particular, ARDS and primary graft dysfunction post-lung transplantation.
- The mechanisms of alveolar epithelial dysfunction and development of alveolar oedema.
- Translational modelling of critical illness.
- Cell death mecahnisms during ICU acquired muscle wasting.
- Mechanisms of failure to wean from mechanical ventilation.
Patel BV, Barrett NA, Vuylsteke A, 2018, Correspondance: ECMO for Severe Acute Respiratory Distress Syndrome, New England Journal of Medicine, ISSN:0028-4793, Pages:1090-1093
et al., 2018, Intracranial Hemorrhage and Early Mortality in Patients Receiving Extracorporeal Membrane Oxygenation for Severe Respiratory Failure, Seminars in Thrombosis and Hemostasis, Vol:44, ISSN:0094-6176, Pages:276-286
et al., 2018, Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury, Thorax, Vol:73, ISSN:0040-6376, Pages:350-360
et al., 2017, High-Fat Feeding Protects Mice From Ventilator-Induced Lung Injury, Via Neutrophil-Independent Mechanisms, Critical Care Medicine, Vol:45, ISSN:0090-3493, Pages:E831-E839
et al., Modulation Of Mechanical Ventilation-Induced Alveolar Epithelial Cell Death Signaling By Underlying Lung Inflammation, American Thoracic Society 2018, American Thoracic Society