Dr Bryn Owen is a molecular endocrinologist with training in nuclear hormone receptor (NR) signalling. He uses model systems to understand the adaptive processes that maintain whole-body energy homeostasis during periods of fluctuating nutrient availability. As a Wellcome Trust Sir Henry Dale Fellow, Dr Owen is investigating how the cellular receptor for estrogen (ER-alpha) in the hypothalamus controls the timing and progression of the ovulatory cycle. He is particularly interested in how this control is lost during nutritional challenges such as anorexia and obesity. He is developing novel transgenic, proteomic, and in vitro systems to answer this question. Dr Owen is also interested in the hypothalamic pathways responsible for the reward-value of nutrient, and the thermogenic potential of the brown adipose tissue (BAT) as a target for anti-obesity therapies.
Owen B, Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1, Scientific Reports, ISSN:2045-2322
et al., 2019, Steroidogenic control of liver metabolism through a nuclear receptor-network, Molecular Metabolism, Vol:30, ISSN:2212-8778, Pages:221-229
et al., 2018, Targeting GLP-1 receptor trafficking to improve agonist efficacy, Nature Communications, Vol:9, ISSN:2041-1723
et al., 2016, Impaired 17,20-lyase activity in male mice lacking cytochrome b5 in Leydig cells, Molecular Endocrinology, Vol:30, ISSN:1944-9917, Pages:469-478
et al., 2016, A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects, Cell Metabolism, Vol:23, ISSN:1550-4131, Pages:427-440