Dr Bryn Owen is a molecular endocrinologist with training in nuclear hormone receptor (NR) signalling. He uses model systems to understand the adaptive processes that maintain whole-body energy homeostasis during periods of fluctuating nutrient availability. As a Wellcome Trust Sir Henry Dale Fellow, Dr Owen is investigating how the cellular receptor for estrogen (ER-alpha) in the hypothalamus controls the timing and progression of the ovulatory cycle. He is particularly interested in how this control is lost during nutritional challenges such as anorexia and obesity. He is developing novel transgenic, proteomic, and in vitro systems to answer this question. Dr Owen is also interested in the hypothalamic pathways responsible for the reward-value of nutrient, and the thermogenic potential of the brown adipose tissue (BAT) as a target for anti-obesity therapies.
et al., 2016, Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b(5) in Leydig Cells, Molecular Endocrinology, Vol:30, ISSN:0888-8809, Pages:469-478
et al., 2016, FGF21 Regulates Sweet and Alcohol Preference, Cell Metabolism, Vol:23, ISSN:1550-4131, Pages:344-349
et al., 2016, A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects, Cell Metabolism, Vol:23, ISSN:1550-4131, Pages:427-440
Fernandes-Freitas I, Owen BM, 2015, Metabolic roles of endocrine fibroblast growth factors, Current Opinion in Pharmacology, Vol:25, ISSN:1471-4892, Pages:30-35
Owen BM, Mangelsdorf DJ, Kliewer SA, 2015, Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21., Trends Endocrinol Metab, Vol:26, Pages:22-29