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@article{Fernandes-Freitas:2020:10.1038/s41598-020-58788-9,
author = {Fernandes-Freitas, I and Milona, A and Murphy, KG and Dhillo, WS and Owen, B},
doi = {10.1038/s41598-020-58788-9},
journal = {Scientific Reports},
title = {Live birth in sex-reversed XY mice lacking the nuclear receptor Dax1},
url = {http://dx.doi.org/10.1038/s41598-020-58788-9},
volume = {10},
year = {2020}
}

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TY  - JOUR
AB  - The nuclear hormone receptor Dax1 functions during development as a testes-determining gene. However, the phenotype of male mice lacking Dax1 is strain-dependent due to the background-specific abundance of male-determining Sry gene-transcripts. We hypothesised that inter-individual variation in Sry mRNA-abundance would result in a spectrum of phenotypes even within-strain. We found that while all XY C57BL/6J mice lacking Dax1 presented as phenotypic females, there was a marked inter-individual variability in measures of fertility. Indeed, we report rare occasions where sex-reversed mice had measures of fertility comparable to those in control females. On two occasions, these sex-reversed XY mice were able to give birth to live offspring following mating to stud-males. As such, this work documents within-strain variability in phenotypes of XY mice lacking Dax1, and reports for the first time a complete sex-reversal capable of achieving live birth in these mice.
AU  - Fernandes-Freitas,I
AU  - Milona,A
AU  - Murphy,KG
AU  - Dhillo,WS
AU  - Owen,B
DO  - 10.1038/s41598-020-58788-9
PY  - 2020///
SN  - 2045-2322
TI  - Live birth in sex-reversed XY mice lacking the nuclear receptor Dax1
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-58788-9
UR  - http://hdl.handle.net/10044/1/76796
VL  - 10
ER  -

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