Imperial College London
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DrBrynOwen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

bryn.owen05

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bookout:2013:10.1038/nm.3249,
author = {Bookout, AL and de, Groot MHM and Owen, BM and Lee, S and Gautron, L and Lawrence, HL and Ding, X and Elmquist, JK and Takahashi, JS and Mangelsdorf, DJ and Kliewer, SA},
doi = {10.1038/nm.3249},
journal = {NATURE MEDICINE},
pages = {1147--1152},
title = {FGF21 regulates metabolism and circadian behavior by acting on the nervous system},
url = {http://dx.doi.org/10.1038/nm.3249},
volume = {19},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fibroblast growth factor 21 (FGF21) is a hepatokine that acts as a global starvation signal to modulate fuel partitioning and metabolism and repress growth1; however, the site of action of these diverse effects remains unclear. FGF21 signals through a heteromeric cell-surface receptor composed of one of three FGF receptors (FGFR1c, FGFR2c or FGFR3c) in complex with β-Klotho2,3,4, a single-pass transmembrane protein that is enriched in metabolic tissues5. Here we show that in addition to its known effects on peripheral metabolism, FGF21 increases systemic glucocorticoid levels, suppresses physical activity and alters circadian behavior, which are all features of the adaptive starvation response. These effects are mediated through β-Klotho expression in the suprachiasmatic nucleus of the hypothalamus and the dorsal vagal complex of the hindbrain. Mice lacking the gene encoding β-Klotho (Klb) in these regions are refractory to these effects, as well as those on metabolism, insulin and growth. These findings demonstrate a crucial role for the nervous system in mediating the diverse physiologic and pharmacologic actions of FGF21.
AU  - Bookout,AL
AU  - de,Groot MHM
AU  - Owen,BM
AU  - Lee,S
AU  - Gautron,L
AU  - Lawrence,HL
AU  - Ding,X
AU  - Elmquist,JK
AU  - Takahashi,JS
AU  - Mangelsdorf,DJ
AU  - Kliewer,SA
DO  - 10.1038/nm.3249
EP  - 1152
PY  - 2013///
SN  - 1078-8956
SP  - 1147
TI  - FGF21 regulates metabolism and circadian behavior by acting on the nervous system
T2  - NATURE MEDICINE
UR  - http://dx.doi.org/10.1038/nm.3249
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324083500029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/58875
VL  - 19
ER  -
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