Imperial College London
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DrBrynOwen

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

bryn.owen05

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fernandes-Freitas:2015:10.1016/j.coph.2015.09.014,
author = {Fernandes-Freitas, I and Owen, BM},
doi = {10.1016/j.coph.2015.09.014},
journal = {Current Opinion in Pharmacology},
pages = {30--35},
title = {Metabolic roles of endocrine fibroblast growth factors},
url = {http://dx.doi.org/10.1016/j.coph.2015.09.014},
volume = {25},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Considerable effort is currently being devoted to understanding the physiological and pharmacological action of the endocrine fibroblast growth factors (FGFs). These three proteins (FGF15/19, FGF21 and FGF23) act in a tissue-specific manner through a membrane-complex consisting of an FGF-receptor and α/βKlotho. FGF15/19 is produced in the intestine and regulates postprandial liver metabolism and gallbladder filling. FGF21 is largely liver-derived and co-ordinates adaptive changes in response to nutritional and physiological stresses. FGF23 signals from the bone to the kidney to maintain phosphate homeostasis. In pharmacological settings, FGF15/19, FGF21, and the prototypical FGF1, potentially represent novel treatments for obesity and diabetes. This review summarises the recent advances in our understanding of the biology of these important metabolic regulators.
AU  - Fernandes-Freitas,I
AU  - Owen,BM
DO  - 10.1016/j.coph.2015.09.014
EP  - 35
PY  - 2015///
SN  - 1471-4892
SP  - 30
TI  - Metabolic roles of endocrine fibroblast growth factors
T2  - Current Opinion in Pharmacology
UR  - http://dx.doi.org/10.1016/j.coph.2015.09.014
VL  - 25
ER  -
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