Imperial College London

Prof Claire S. Adjiman FREng

Faculty of EngineeringDepartment of Chemical Engineering

Professor of Chemical Engineering



+44 (0)20 7594 6638c.adjiman Website




Ms Sevgi Thompson +44 (0)20 7594 1478




608Roderic Hill BuildingSouth Kensington Campus






BibTex format

author = {Chen, Q and Paulavicius, R and Adjiman, CSJ and Garcia-Munoz, S},
doi = {10.1002/aic.16214},
journal = {AIChE Journal},
pages = {3944--3957},
title = {An optimization framework to combine operable space maximization with design of experiments.},
url = {},
volume = {64},
year = {2018}

RIS format (EndNote, RefMan)

AB - The introduction of Quality by Design in the pharmaceutical industry stimulates practitioners to better understand the relationship of materials, processes and products. One way to achieve this is through the use of targeted experimentation. In this study, we present an optimization framework to design experiments that effectively leverage parameterized process models to maximize the space covered in the output variables while also obtaining an orthogonal bracketing study in the process input factors. The framework considers both multiobjective and bilevel optimization methods for relating the two maximization objectives. Results are presented for two case studies—a spray coating process and a continuously stirred reactor cascade—demonstrating the ability to generate and identify efficient designs with fitforpurpose tradeoffs between bracketed orthogonality in the input factors and volume explored in the process output space.
AU - Chen,Q
AU - Paulavicius,R
AU - Adjiman,CSJ
AU - Garcia-Munoz,S
DO - 10.1002/aic.16214
EP - 3957
PY - 2018///
SN - 0001-1541
SP - 3944
TI - An optimization framework to combine operable space maximization with design of experiments.
T2 - AIChE Journal
UR -
UR -
VL - 64
ER -