Imperial College London


Faculty of MedicineDepartment of Medicine

Chair of Immunology



+44 (0)20 7594 3730c.bangham Website




Ms Linda Hollick +44 (0)20 7594 3729




115Wright Fleming WingSt Mary's Campus





BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
PhD 1987
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006

During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.

Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.



Niewiesk S, Daenke S, Parker CE, et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653

Kagdi HH, Demontis MA, Fields PA, et al., 2017, Risk stratification of adult T-cell leukemia/lymphoma using immunophenotyping., Cancer Med, Vol:6, Pages:298-309

Turpin J, Alais S, Marçais A, et al., 2017, Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity., Cancer Lett, Vol:389, Pages:78-85

Willems L, Hasegawa H, Accolla R, et al., 2017, Reducing the global burden of HTLV-1 infection: An agenda for research and action, Antiviral Research, Vol:137, ISSN:0166-3542, Pages:41-48

Cook LBM, Melamed A, Demontis MA, et al., 2016, Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients, Retrovirology, Vol:13, ISSN:1742-4690

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