BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653
Billman MR, Rueda D, Bangham CRM, 2017, Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1., Wellcome Open Res, Vol:2, ISSN:2398-502X
Gillet NA, Melamed A, Bangham CRM, 2017, High-Throughput Mapping and Clonal Quantification of Retroviral Integration Sites., Methods Mol Biol, Vol:1582, Pages:127-141
et al., 2017, Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1., Cell Chem Biol
et al., 2017, The impact of HTLV-1 on the cellular genome., Curr Opin Virol, Vol:26, Pages:125-131