BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653
et al., 2017, Risk stratification of adult T-cell leukemia/lymphoma using immunophenotyping., Cancer Med, Vol:6, Pages:298-309
et al., 2017, Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity., Cancer Lett, Vol:389, Pages:78-85
et al., 2017, Reducing the global burden of HTLV-1 infection: An agenda for research and action, Antiviral Research, Vol:137, ISSN:0166-3542, Pages:41-48
et al., 2016, Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients, Retrovirology, Vol:13, ISSN:1742-4690