BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
et al., The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis, Elife, ISSN:2050-084X
et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653
et al., 2018, Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model (vol 7, 6913, 2017), Scientific Reports, Vol:8, ISSN:2045-2322
Kulkarni A, Bangham CRM, 2018, HTLV-1: Regulating the Balance Between Proviral Latency and Reactivation, Frontiers in Microbiology, Vol:9, ISSN:1664-302X
et al., 2018, Long-term clinical remission maintained after cessation of zidovudine and interferon-alpha therapy in chronic adult T-cell leukemia/lymphoma, International Journal of Hematology, Vol:107, ISSN:0925-5710, Pages:378-382