Summary
BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
PhD 1987
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
Publications
Journals
Bangham CRM, Melamed A, Yaguchi H, et al., The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis, Elife, ISSN:2050-084X
Niewiesk S, Daenke S, Parker CE, et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653
Satou Y, Katsuya H, Fukuda A, et al., 2018, Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model (vol 7, 6913, 2017), Scientific Reports, Vol:8, ISSN:2045-2322
Kulkarni A, Bangham CRM, 2018, HTLV-1: Regulating the Balance Between Proviral Latency and Reactivation, Frontiers in Microbiology, Vol:9, ISSN:1664-302X
Cook LB, Rowan AG, Demontis MA, et al., 2018, Long-term clinical remission maintained after cessation of zidovudine and interferon-alpha therapy in chronic adult T-cell leukemia/lymphoma, International Journal of Hematology, Vol:107, ISSN:0925-5710, Pages:378-382