Summary
BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
PhD 1987
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the virology and immunology of persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I) - see https://doi.org/10.26320/SCIENTIA225
. Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
Publications
Journals
Cook L, Demontis MA, Sagawe S, et al., Molecular remissions are observed in chronic adult T cell leukemia/lymphoma in patients treated with mogamulizumab, Haematologica, ISSN:0390-6078
Turpin J, Yurick D, Khoury G, et al., 2019, Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia., J Infect Dis, Vol:219, Pages:562-567
Kulkarni A, Taylor GP, Klose RJ, et al., 2018, Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1, Jci Insight, Vol:3, ISSN:2379-3708
Katsuya H, Cook LBM, Rowan AG, et al., 2018, Phosphatidylinositol 3-kinase-delta (PI3K-delta) is a potential therapeutic target in adult T-cell leukemia-lymphoma, Biomarker Research, Vol:6, ISSN:2050-7771
Melamed A, Yaguchi H, Miura M, et al., 2018, The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis, Elife, Vol:7, ISSN:2050-084X