Imperial College London

ProfessorCharlesBangham

Faculty of MedicineDepartment of Medicine

Chair of Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3730c.bangham Website

 
 
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Assistant

 

Ms Linda Hollick +44 (0)20 7594 3729

 
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Location

 

115Wright Fleming WingSt Mary's Campus

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Summary

 

Summary

BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
PhD 1987
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006

During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.

Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.

Publications

Journals

Niewiesk S, Daenke S, Parker CE, et al., Naturally occurring variants of HTLV-I tax protein impair its recognition by CTL and the transactivation function of Tax., Journal of Virology, Vol:69, ISSN:1098-5514, Pages:2649-2653

Billman MR, Rueda D, Bangham CRM, 2017, Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1., Wellcome Open Res, Vol:2, ISSN:2398-502X

Gillet NA, Melamed A, Bangham CRM, 2017, High-Throughput Mapping and Clonal Quantification of Retroviral Integration Sites., Methods Mol Biol, Vol:1582, Pages:127-141

Kulkarni A, Mateus M, Thinnes CC, et al., 2017, Glucose Metabolism and Oxygen Availability Govern Reactivation of the Latent Human Retrovirus HTLV-1., Cell Chem Biol

Cook L, Melamed A, Yaguchi H, et al., 2017, The impact of HTLV-1 on the cellular genome., Curr Opin Virol, Vol:26, Pages:125-131

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