BA Cambridge 1976
BM, BCh Oxford 1980
MRCP (UK) 1983
FRC Path 1999
Fellow of the Academy of Medical Sciences (2003)
ScD Cambridge 2006
During my medical training I carried out studies on lung function, genetic polymorphisms, endocrine function and demography in high altitude populations in Nepal. In my PhD I established a model of respiratory syncytial (RS) virus infection in the mouse, and studied the T lymphocyte response to RS virus first in the mouse and then in the human.
Since 1987 I have studied the immune response to persistent virus infections, in particular infection with the human T-cell leukaemia virus (HTLV-I). Our aim is to produce a comprehensive, coherent, qualitative and quantitative understanding of the persistence of HTLV-I and the immune response to HTLV-I, and an explanation of why certain individuals infected with HTLV-I develop fatal or disabling diseases while the majority remain asymptomatic. We use a broad range of techniques in molecular and cellular immunology, viral and host genetics, cell biology, DNA expression microarrays, proteomics and mathematics.
et al., 2016, yy CADM1/TSLC1 Identifies HTLV-1-Infected Cells and Determines Their Susceptibility to CTL-Mediated Lysis, Plos Pathogens, Vol:12, ISSN:1553-7366
et al., 2016, Rapid dissemination of human T-lymphotropic virus type 1 during primary infection in transplant recipients, Retrovirology, Vol:13, ISSN:1742-4690
et al., 2016, The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:3054-3059
Laydon DJ, Bangham CRM, Asquith B, 2015, Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach, Philosophical Transactions of the Royal Society B-biological Sciences, Vol:370, ISSN:0962-8436
et al., 2015, Immune Compromise in HIV-1/HTLV-1 Coinfection With Paradoxical Resolution of CD4 Lymphocytosis During Antiretroviral Therapy A Case Report, Medicine, Vol:94, ISSN:0025-7974