109 results found
Bahou K, Braddock D, Meyer A, et al., A relay strategy actuates pre-existing trisubstituted olefins in monoterpenoids for cross metathesis with trisubstituted alkenes, The Journal of Organic Chemistry, ISSN: 0022-3263
A retrosynthetic disconnection-reconnection analysis of epoxypolyenes – substrates that can undergo cyclization to podocarpane-type tricycles – reveals relay-actuated 6,7-functionalized monoterpenoid alcohols for ruthenium benzylidene catalyzed olefin cross metathesis with homoprenyl benzenes. Successful implementation of this approach provided several epoxypolyenes as expected (E:Z, ca. 2-3:1). The method is further generalized for the cross metathesis of pre-existing trisubstituted olefins in other relay-actuated 6,7-functionalized monoterpenoid alcohols with various other trisubstituted alkenes to form new trisubstituted olefins. Epoxypolyene cyclization of an enantiomerically pure, but geometrically impure, epoxypolyene substrate provides an enantiomerically pure, trans-fused, podocarpane-type tricycle (from the E-geometrical isomer).
Lo Q, Sale D, Braddock D, et al., 2019, New insights into the reaction capabilities of ionic organic bases in cu-catalysed amination, European Journal of Organic Chemistry, Vol: 2019, Pages: 1944-1951, ISSN: 1099-0690
The application of ionic organic bases in the copper‐catalyzed amination reaction (Ullmann reaction) has been studied at room temperature, with sub‐mol‐% catalyst loadings, and with more challenging amines at elevated temperatures. The cation present in the base has been shown to have little effect on the reaction at standard catalyst and ancillary ligand loadings, whereas the choice of anion is crucial for good reactivity. A substrate scope carried out at room temperature with the best performing bases, TBAM and TBPM, showed both bases to be highly effective under these mild reaction conditions. Moreover, under sub‐mol % catalyst loadings and room temperature conditions, TBPM gave good to excellent yields for a number of different amines and functionalized aryl iodides (14 examples). However, reactions involving more challenging amines gave little or no yield. By using more forceful conditions (120 °C) moderate to excellent yields of cross‐coupled products containing more challenging amines was achievable using TBPM and to a lesser extent with TBAM. As part of this work a study on the stability of the organic bases at 120 °C was undertaken. TBAM is shown to decompose to give nBu3N and mono‐butylmalonate at higher temperatures, and this can be correlated to a decrease in performance in the coupling reaction. The phosphonium cations in TBPM did not undergo analogous reactivity but were shown instead to experience some degree of deprotonation at the α‐CH2 to generate phosphonium ylides. This however did not lead to a significantly degradation in the activity of the TBPM in the cross‐coupling reaction.
Braddock DC, Lickiss PD, Rowley BC, et al., 2018, Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids, ORGANIC LETTERS, Vol: 20, Pages: 950-953, ISSN: 1523-7060
Lo QA, Sale D, Braddock DC, et al., 2018, Mechanistic and Performance Studies on the Ligand-Promoted Ullmann Amination Reaction, ACS CATALYSIS, Vol: 8, Pages: 101-109, ISSN: 2155-5435
Bahou KA, Braddock DC, Meyer AG, et al., 2017, Kinetic Benchmarking Reveals the Competence of Prenyl Groups in Ring-Closing Metathesis, ORGANIC LETTERS, Vol: 19, Pages: 5332-5335, ISSN: 1523-7060
Clarke J, Bonney KJ, Yaqoob M, et al., 2016, Epimeric Face-Selective Oxidations and Diastereodivergent Transannular Oxonium Ion Formation Fragmentations: Computational Modeling and Total Syntheses of 12-Epoxyobtusallene IV, 12-Epoxyobtusallene II, Obtusallene X, Marilzabicycloallene C, and Marilzabicycloallene D, Journal of Organic Chemistry, Vol: 81, Pages: 9539-9552, ISSN: 0022-3263
© 2016 American Chemical Society. The total syntheses of 12-epoxyobtusallene IV, 12-epoxyobtusallene II, obtusallene X, marilzabicycloallene C, and marilzabicycloallene D as halogenated C15-acetogenin 12-membered bicyclic and tricyclic ether bromoallene-containing marine metabolites from Laurencia species are described. Two enantiomerically pure C4-epimeric dioxabicyclo[8.2.1]tridecenes were synthesized by E-selective ring-closing metathesis where their absolute stereochemistry was previously set via catalytic asymmetric homoallylic epoxidation and elaborated via regioselective epoxide-ring opening and diastereoselective bromoetherification. Epimeric face-selective oxidation of their Δ12,13 olefins followed by bromoallene installation allowed access to the oppositely configured 12,13-epoxides of 12-epoxyobtusallene II and 12-epoxyobtusallene IV. Subsequent exploration of their putative biomimetic oxonium ion formation-fragmentations reactions revealed diastereodivergent pathways giving marilzabicycloallene C and obtusallene X, respectively. The original configurations of the substrates evidently control oxonium ion formation and their subsequent preferred mode of fragmentation by nucleophilic attack at C9 or C12. Quantum modeling of this stereoselectivity at the ωB97X-D/Def2-TZVPPD/SCRF = methanol level revealed that in addition to direction resulting from hydrogen bonding, the dipole moment of the ion-pair transition state is an important factor. Marilzabicycloallene D as a pentahalogenated 12-membered bicyclic ether bromoallene was synthesized by a face-selective chloronium ion initiated oxonium ion formation-fragmentation process followed by subsequent bromoallene installation.
The first stable bromoallene oxides were obtained by the DMDO epoxidation of 1-bromo-1,3-di-tert-alkylallenes, producing the first crystalline allene oxide of any kind. The epoxidations are regioselective for the bromine-bearing Δ1,2 alkene, and also face selective producing single diastereomer E-olefin products.
Sung S, Sale D, Braddock DC, et al., 2016, Mechanistic Studies on the Copper-Catalyzed N-Arylation of Alkylamines Promoted by Organic Soluble Ionic Bases, ACS CATALYSIS, Vol: 6, Pages: 3965-3974, ISSN: 2155-5435
Campbell J, Burgal JDS, Szekely G, et al., 2016, Hybrid polymer/MOF membranes for Organic Solvent Nanofiltration (OSN): Chemical modification and the quest for perfection, Journal of Membrane Science, Vol: 503, Pages: 166-176, ISSN: 0376-7388
© 2016 Elsevier B.V.. One of the main challenges in the field of Organic Solvent Nanofiltration (OSN) is to improve the selectivity of membranes, allowing the separation of closely related solutes. This objective might be achieved by constructing membranes with uniform porous structures. Hybrid Polymer/Metal Organic Framework (MOF) membranes were prepared by in-situ growth (ISG) of HKUST-1 within the pores of polyimide membranes. To improve the performances of ISG membranes, chemical modification was performed. Aryl carboxylic acid moieties were introduced to polyimide P84 ultrafiltration membranes allowing coordination of the HKUST-1 directly on to the polymer. Chemically modified ISG membranes outperformed non-modified ISG membranes in both solute retentions and permeance. Retentions of polystyrene solute in acetone were used to calculate theoretical pore size distributions for each of the membranes tested. It was found that the chemically modified ISG membrane had he narrowest calculated pore size distribution.
Sung S, Braddock DC, Armstrong A, et al., 2015, Synthesis, Characterisation and Reactivity of Copper(I) Amide Complexes and Studies on Their Role in the Modified Ullmann Amination Reaction, CHEMISTRY-A EUROPEAN JOURNAL, Vol: 21, Pages: 7179-7192, ISSN: 0947-6539
Campbell J, Davies RP, Braddock DC, et al., 2015, Improving the permeance of hybrid polymer/metal-organic framework (MOF) membranes for organic solvent nanofiltration (OSN) - development of MOF thin films via interfacial synthesis, JOURNAL OF MATERIALS CHEMISTRY A, Vol: 3, Pages: 9668-9674, ISSN: 2050-7488
Kim M-S, Buisson LA, Heathcote DA, et al., 2014, Approaches to design non-covalent inhibitors for human granzyme B (hGrB), ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 12, Pages: 8952-8965, ISSN: 1477-0520
Braddock DC, Gao AX, White AJP, et al., 2014, Studies towards the synthesis of halomon: asymmetric hexafunctionalisation of myrcene, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 13725-13728, ISSN: 1359-7345
Braddock DC, Sbircea D-T, 2014, Proof-of-principle direct double cyclisation of a linear C-15-precursor to a dibrominated bicyclic medium-ring ether relevant to Laurencia species, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 12691-12693, ISSN: 1359-7345
Campbell J, Szekely G, Davies RP, et al., 2014, Fabrication of hybrid polymer/metal organic framework membranes: mixed matrix membranes versus in situ growth, JOURNAL OF MATERIALS CHEMISTRY A, Vol: 2, Pages: 9260-9271, ISSN: 2050-7488
Armstrong A, Braddock DC, Jones AX, et al., 2013, Catalytic asymmetric bromolactonization reactions using (DHQD)(2)PHAL-benzoic acid combinations, TETRAHEDRON LETTERS, Vol: 54, Pages: 7004-7008, ISSN: 0040-4039
Braddock DC, Marklew JS, Foote KM, et al., 2013, An Enantiospecific Polyene Cyclization Initiated by an Enantiomerically Pure Bromonium Ion, CHIRALITY, Vol: 25, Pages: 692-700, ISSN: 0899-0042
Braddock DC, Clarke J, Rzepa HS, 2013, Epoxidation of bromoallenes connects red algae metabolites by an intersecting bromoallene oxide - Favorskii manifold, CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 11176-11178, ISSN: 1359-7345
Bonney KJ, Braddock DC, 2012, A Unifying Stereochemical Analysis for the Formation of Halogenated C-15-Acetogenin Medium-Ring Ethers From Laurencia Species via Intramolecular Bromonium Ion Assisted Epoxide Ring-Opening and Experimental Corroboration with a Model Epoxide, JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 9574-9584, ISSN: 0022-3263
Braddock DC, Roy D, Lenoir D, et al., 2012, Verification of stereospecific dyotropic racemisation of enantiopure D and L-1,2-dibromo-1,2-diphenylethane in non-polar media, CHEMICAL COMMUNICATIONS, Vol: 48, Pages: 8943-8945, ISSN: 1359-7345
Barrett TN, Braddock DC, Monta A, et al., 2011, Total Synthesis of the Marine Metabolite (+/-)-Polysiphenol via Highly Regioselective Intramolecular Oxidative Coupling, JOURNAL OF NATURAL PRODUCTS, Vol: 74, Pages: 1980-1984, ISSN: 0163-3864
Bonney KJ, Braddock DC, White AJP, et al., 2011, Intramolecular Bromonium Ion Assisted Epoxide Ring-Opening: Capture of the Oxonium Ion with an Added External Nucleophile, JOURNAL OF ORGANIC CHEMISTRY, Vol: 76, Pages: 97-104, ISSN: 0022-3263
Braddock DC, Marklew JS, Thomas AJF, 2011, Enantiospecific bromonium ion generation and intramolecular capture: a model system for asymmetric bromonium ion-induced polyene cyclisations, CHEMICAL COMMUNICATIONS, Vol: 47, Pages: 9051-9053, ISSN: 1359-7345
Braddock DC, Cailleau T, Cansell G, et al., 2010, The reaction of aromatic dialdehydes with enantiopure 1,2-diamines: an expeditious route to enantiopure tricyclic amidines, TETRAHEDRON-ASYMMETRY, Vol: 21, Pages: 2911-2919, ISSN: 0957-4166
Braddock DC, Pouwer RH, Burton JW, et al., 2009, Clarification of the Stereochemical Course of Nucleophilic Substitution of Arylsulfonate-Based Nucleophile Assisting Leaving Groups, JOURNAL OF ORGANIC CHEMISTRY, Vol: 74, Pages: 6042-6049, ISSN: 0022-3263
Braddock DC, Millan DS, Perez-Fuertes Y, et al., 2009, Bromonium Ion Induced Transannular Oxonium Ion Formation-Fragmentation in Model Obtusallene Systems and Structural Reassignment of Obtusallenes V-VII, JOURNAL OF ORGANIC CHEMISTRY, Vol: 74, Pages: 1835-1841, ISSN: 0022-3263
Braddock DC, Hermitage SA, Kwok L, et al., 2009, The generation and trapping of enantiopure bromonium ions, CHEMICAL COMMUNICATIONS, Pages: 1082-1084, ISSN: 1359-7345
Braddock DC, Rzepa HS, 2008, Structural reassignment of obtusallenes V, VI, and VII by GIAO-based density functional prediction, JOURNAL OF NATURAL PRODUCTS, Vol: 71, Pages: 728-730, ISSN: 0163-3864
Braddock DC, Bhuva R, Perez-Fuertes Y, et al., 2008, The stereochemical course of bromoetherification of enynes, CHEMICAL COMMUNICATIONS, Pages: 1419-1421, ISSN: 1359-7345
Ahmad SM, Braddock DC, Cansell G, et al., 2007, Amidines as potent nucleophilic organocatalysts for the transfer of electrophilic bromine from N-bromosuccinimide to alkenes, TETRAHEDRON LETTERS, Vol: 48, Pages: 5948-5952, ISSN: 0040-4039
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