Imperial College London
Alternate

Dr Chris Cantwell

Faculty of Engineering, Department of Aeronautics

Senior Lecturer in Aeronautics
 
 
 
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Contact

 

+44 (0)20 7594 5050c.cantwell Website

 
 
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Location

 

Department of Aeronautics, Room 219City and Guilds BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clayton:2020:10.1098/rsta.2019.0335,
author = {Clayton, RH and Aboelkassem, Y and Cantwell, CD and Corrado, C and Delhaas, T and Huberts, W and Lei, CL and Ni, H and Panfilov, AV and Roney, C and Dos, Santos RW},
doi = {10.1098/rsta.2019.0335},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
pages = {1--21},
title = {An audit of uncertainty in multi-scale cardiac electrophysiology models.},
url = {http://dx.doi.org/10.1098/rsta.2019.0335},
volume = {378},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Models of electrical activation and recovery in cardiac cells and tissue have become valuable research tools, and are beginning to be used in safety-critical applications including guidance for clinical procedures and for drug safety assessment. As a consequence, there is an urgent need for a more detailed and quantitative understanding of the ways that uncertainty and variability influence model predictions. In this paper, we review the sources of uncertainty in these models at different spatial scales, discuss how uncertainties are communicated across scales, and begin to assess their relative importance. We conclude by highlighting important challenges that continue to face the cardiac modelling community, identifying open questions, and making recommendations for future studies. This article is part of the theme issue 'Uncertainty quantification in cardiac and cardiovascular modelling and simulation'.
AU  - Clayton,RH
AU  - Aboelkassem,Y
AU  - Cantwell,CD
AU  - Corrado,C
AU  - Delhaas,T
AU  - Huberts,W
AU  - Lei,CL
AU  - Ni,H
AU  - Panfilov,AV
AU  - Roney,C
AU  - Dos,Santos RW
DO  - 10.1098/rsta.2019.0335
EP  - 21
PY  - 2020///
SN  - 1364-503X
SP  - 1
TI  - An audit of uncertainty in multi-scale cardiac electrophysiology models.
T2  - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
UR  - http://dx.doi.org/10.1098/rsta.2019.0335
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32448070
UR  - https://royalsocietypublishing.org/doi/10.1098/rsta.2019.0335
UR  - http://hdl.handle.net/10044/1/81032
VL  - 378
ER  -
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