Chris Chiu is a Clinical Senior Lecturer and Honorary Consultant in the Department of Infectious Diseases. He underwent his basic medical training at Cambridge and Oxford Universities, and later was awarded a Wellcome Trust Clinical Research Training fellowship to undertake a PhD with Charles Bangham and Margaret Callan at Imperial College, investigating gene transcription signatures of the early CD8+ T cell response to acute viral infection. On completion of his specialist clinical training, he was awarded an MRC Clinician Scientist fellowship and furthered his research by working with Rafi Ahmed's group at Emory University, examining adaptive immune responses to influenza and varicella zoster virus vaccines.
His research interests focus mainly on B and T cell immunity to recurrent viral infections, including respiratory syncytial virus (RSV), influenza and herpesviruses, with a particular emphasis on the development of better vaccines. He leads a group primarily using experimental infection of volunteers to investigate systemic and mucosal immunity against influenza and RSV. These highly specialised models provide a unique opportunity to examine correlates and mechanisms of protection and disease severity in human beings. The work now encompasses early phase clinical vaccine trials as well as fundamental studies of human immunity, which together enhance our understanding of how colds and flu-like illnesses may be prevented.
et al., 2020, Epitope-specific airway-resident CD4+ T-cell dynamics during experimental human RSV infection, Journal of Clinical Investigation, Vol:130, ISSN:0021-9738, Pages:523-538
et al., 2019, Local and systemic immunity against RSV induced by a novel intranasal vaccine: A randomised, double- blind, placebo-controlled trial, American Journal of Respiratory and Critical Care Medicine, Vol:200, ISSN:1073-449X, Pages:481-492
et al., 2018, A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection, Nature Communications, Vol:9, ISSN:2041-1723
Ascough SC, Paterson S, Chiu C, 2018, Induction and subversion of human protective immunity: contrasting influenza and respiratory syncytial virus, Frontiers in Immunology, Vol:9, ISSN:1664-3224
et al., 2016, Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection, Nature Communications, Vol:7, ISSN:2041-1723
et al., 2015, Impaired Antibody-mediated Protection and Defective IgA B Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus., American Journal of Respiratory and Critical Care Medicine, ISSN:1535-4970
Chiu C, Openshaw PJ, 2015, Antiviral B cell and T cell immunity in the lungs, Nature Immunology, Vol:16, ISSN:1529-2908, Pages:18-26
et al., 2014, Broadly Reactive Human CD8 T Cells that Recognize an Epitope Conserved between VZV, HSV and EBV, PLOS Pathogens, Vol:10, ISSN:1553-7366
et al., 2012, Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells., Proc Natl Acad Sci U S A, Vol:109, Pages:9047-9052
et al., 2007, Early acquisition of cytolytic function and transcriptional changes in a primary CD8(+) T-cell response in vivo, Blood, Vol:109, ISSN:0006-4971, Pages:1086-1094