Imperial College London
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ProfessorChristopherChiu

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 2301c.chiu Website

 
 
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Location

 

8N.15Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jozwik:2015:10.1038/ncomms10224,
author = {Jozwik, A and Habibi, MS and Paras, A and Zhu, J and Guvenel, A and Dhariwal, J and Almond, M and Wong, EHC and Sykes, A and Maybeno, M and Del, Rosario J and Trujillo-Torralbo, M and Mallia, P and Sidney, J and Peters, B and Kon, OM and Sette, A and Johnston, SL and Openshaw, PJ and Chiu, C},
doi = {10.1038/ncomms10224},
journal = {Nature Communications},
pages = {1--17},
title = {RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection},
url = {http://dx.doi.org/10.1038/ncomms10224},
volume = {6},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination but their importance in man has not been determined. Here, using experimental human respiratory syncytial virus (RSV) infection, we investigate systemic and local virus-specific CD8+ T cell responses in adult volunteers. Having defined the immunodominance hierarchy, we analyze phenotype and function longitudinally in blood and by serial bronchoscopy. Despite rapid clinical recovery, we note surprisingly extensive lower airway inflammation with persistent viral antigen and cellular infiltrates. Pulmonary virus-specific CD8+ T cells display a CD69+CD103+ Trm phenotype and accumulate to strikingly high frequencies into convalescence without continued proliferation. These are more highly differentiated but express fewer cytotoxicity markers than in blood, but their abundance prior to infection correlates with protection from more severe disease.
AU  - Jozwik,A
AU  - Habibi,MS
AU  - Paras,A
AU  - Zhu,J
AU  - Guvenel,A
AU  - Dhariwal,J
AU  - Almond,M
AU  - Wong,EHC
AU  - Sykes,A
AU  - Maybeno,M
AU  - Del,Rosario J
AU  - Trujillo-Torralbo,M
AU  - Mallia,P
AU  - Sidney,J
AU  - Peters,B
AU  - Kon,OM
AU  - Sette,A
AU  - Johnston,SL
AU  - Openshaw,PJ
AU  - Chiu,C
DO  - 10.1038/ncomms10224
EP  - 17
PY  - 2015///
SN  - 2041-1723
SP  - 1
TI  - RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection
T2  - Nature Communications
UR  - http://dx.doi.org/10.1038/ncomms10224
UR  - https://www.nature.com/articles/ncomms10224
UR  - http://hdl.handle.net/10044/1/28447
VL  - 6
ER  -
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