Imperial College London
Portrait Picture

ProfessorChristopherChiu

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
//

Contact

 

+44 (0)20 3313 2301c.chiu Website

 
 
//

Location

 

8N.15Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Li:2017:10.1016/j.cell.2017.04.026,
author = {Li, S and Sullivan, NL and Rouphael, N and Yu, T and Banton, S and Maddur, MS and McCausland, M and Chiu, C and Canniff, J and Dubey, S and Liu, K and Tran, V and Hagan, T and Duraisingham, S and Wieland, A and Mehta, AK and Whitaker, JA and Subramaniam, S and Jones, DP and Sette, A and Vora, K and Weinberg, A and Mulligan, MJ and Nakaya, HI and Levin, M and Ahmed, R and Pulendran, B},
doi = {10.1016/j.cell.2017.04.026},
journal = {Cell},
pages = {862--877.e17},
title = {Metabolic Phenotypes of response to vaccination in humans.},
url = {http://dx.doi.org/10.1016/j.cell.2017.04.026},
volume = {169},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Vaccination induces robust antigen-specific antibody, plasmablasts, and CD4(+) T cells yet limited CD8(+) T cell and antiviral responses. The MMRN reveals striking associations between orthogonal datasets, such as transcriptomic and metabolomics signatures, cell populations, and cytokine levels, and identifies immune and metabolic correlates of vaccine immunity. Networks associated with inositol phosphate, glycerophospholipids, and sterol metabolism are tightly coupled with immunity. Critically, the sterol regulatory binding protein 1 and its targets are key integrators of antibody and T follicular cell responses. Our approach is broadly applicable to study human immunity and can help to identify predictors of efficacy as well as mechanisms controlling immunity to vaccination.
AU  - Li,S
AU  - Sullivan,NL
AU  - Rouphael,N
AU  - Yu,T
AU  - Banton,S
AU  - Maddur,MS
AU  - McCausland,M
AU  - Chiu,C
AU  - Canniff,J
AU  - Dubey,S
AU  - Liu,K
AU  - Tran,V
AU  - Hagan,T
AU  - Duraisingham,S
AU  - Wieland,A
AU  - Mehta,AK
AU  - Whitaker,JA
AU  - Subramaniam,S
AU  - Jones,DP
AU  - Sette,A
AU  - Vora,K
AU  - Weinberg,A
AU  - Mulligan,MJ
AU  - Nakaya,HI
AU  - Levin,M
AU  - Ahmed,R
AU  - Pulendran,B
DO  - 10.1016/j.cell.2017.04.026
EP  - 877
PY  - 2017///
SN  - 0092-8674
SP  - 862
TI  - Metabolic Phenotypes of response to vaccination in humans.
T2  - Cell
UR  - http://dx.doi.org/10.1016/j.cell.2017.04.026
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28502771
UR  - https://www.sciencedirect.com/science/article/pii/S0092867417304774?via%3Dihub
VL  - 169
ER  -
Download