Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nicola:2019:10.1038/s41593-019-0415-2,
author = {Nicola, W and Clopath, C},
doi = {10.1038/s41593-019-0415-2},
journal = {Nature Neuroscience},
pages = {1168--1181},
title = {A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus},
url = {http://dx.doi.org/10.1038/s41593-019-0415-2},
volume = {22},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The hippocampus is able to rapidly learn incoming information, even if that information is only observed once.  Further, this information can be replayed in a compressed format in either forward or reverse modes during Sharp Wave Ripples (SPW-Rs).  We leveraged state-of-the-art techniques in training recurrent spiking networks to demonstrate how primarily interneuron networks can:  1) generate internal theta sequences to bind externally elicited spikes in the presence of inhibition from Medial Septum, 2) compress learned spike sequences in the form of a SPW-R when septal inhibition is removed, 3) generate and refine high-frequency assemblies during SPW-R mediated compression,  and 4) regulate the inter-SPW-interval timing between SPW-Rs in ripple clusters. From the fast timescale of neurons to the slow timescale of behaviours, interneuron networks serve as the scaffolding for one-shot learning by replaying, reversing, refining, and regulating spike sequences.
AU  - Nicola,W
AU  - Clopath,C
DO  - 10.1038/s41593-019-0415-2
EP  - 1181
PY  - 2019///
SN  - 1097-6256
SP  - 1168
TI  - A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus
T2  - Nature Neuroscience
UR  - http://dx.doi.org/10.1038/s41593-019-0415-2
UR  - https://www.nature.com/articles/s41593-019-0415-2
UR  - http://hdl.handle.net/10044/1/70274
VL  - 22
ER  -
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