Imperial College London
Alternate

Professor Claudia Clopath

Faculty of Engineering, Department of Bioengineering

Professor of Computational Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 1435c.clopath Website

 
 
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Location

 

Royal School of Mines 4.09Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brzosko:2017:10.7554/eLife.27756,
author = {Brzosko, Z and Zannone, S and Schultz, W and Clopath, C and Paulsen, O},
doi = {10.7554/eLife.27756},
journal = {eLife},
pages = {1--18},
title = {Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation},
url = {http://dx.doi.org/10.7554/eLife.27756},
volume = {6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Spike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP towards synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation towards changing reward locations, as in natural foraging behavior. Thus, temporally sequenced neuromodulation of STDP enables associations to be made between actions and outcomes and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning.
AU  - Brzosko,Z
AU  - Zannone,S
AU  - Schultz,W
AU  - Clopath,C
AU  - Paulsen,O
DO  - 10.7554/eLife.27756
EP  - 18
PY  - 2017///
SN  - 2050-084X
SP  - 1
TI  - Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.27756
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28691903
UR  - https://elifesciences.org/articles/27756
UR  - http://hdl.handle.net/10044/1/51594
VL  - 6
ER  -
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