Dr Charlotte Dean heads the Lung Development and Disease group in the National Heart and Lung Institute.
The Dean group is seeking to understand the cellular and molecular events required to generate the lungs and to use this knowledge to identify novel treatments to repair damaged lung tissue. In a number of lung diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) lung tissue repair is ineffective.
We seek to understand how developmental, environmental or medical factors contribute to adult lung disease and/or injury and ultimately to discover novel treatments to repair or induce regeneration of the lung (see research page for further details).
See website: www.lungdevelopmentandrepair.org
Charlotte Dean undertook her postdoctoral studies in New York with Richard Lang at NYU, and then with Lee Niswander at the Sloan-Kettering Institute, studying the mechanisms of branching morphogenesis in lung and lacrimal gland.
In 2004, Dr Dean returned to the UK to work at MRC Harwell as an independent post-doctoral fellow, continuing studies on lung development and the parallels with lung disease (particularly lung fibrosis and asthma). In 2005 Charlotte was awarded a British Lung Foundation fellowship and became a junior programme leader at MRC Harwell.
Charlotte moved to Imperial College in 2011 and established her group at the National Heart and Lung Institute.
et al., 2021, The Acid Injury and Repair (AIR) model: A new ex vivo tool to understand lung repair, Biomaterials, Vol:267, ISSN:0142-9612
et al., 2020, The planar polarity component Vangl2 is a key regulator of mechanosignaling, Frontiers in Cell and Developmental Biology, Vol:8, ISSN:2296-634X
et al., 2020, Mechanism of lung development in the aetiology of adult congenital pulmonary airway malformations, Thorax, Vol:75, ISSN:0040-6376, Pages:1001-1003
et al., 2020, Lung development genes and adult lung function, American Journal of Respiratory and Critical Care Medicine, Vol:202, ISSN:1073-449X, Pages:853-865
Dean C, Cheong SS, 2019, On the move: the commander IL-4 leads the cell army in collective migration, American Journal of Respiratory Cell and Molecular Biology, Vol:60, ISSN:1044-1549, Pages:377-378
et al., 2019, Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour, Nature Communications, Vol:10, ISSN:2041-1723
Henderson DJ, Long DA, Dean CH, 2018, Planar cell polarity in organ formation, Current Opinion in Cell Biology, Vol:55, ISSN:0955-0674, Pages:96-103
Dean CH, Snelgrove RJ, 2018, New rules for club development: new insights into human small airway epithelial club cell ontogeny and function, American Journal of Respiratory and Critical Care Medicine, Vol:198, ISSN:1073-449X, Pages:1355-1366
Dean CH, Lloyd CM, 2017, Lung Alveolar Repair: Not All Cells Are Equal, Trends in Molecular Medicine, Vol:23, ISSN:1471-4914, Pages:871-873
et al., 2017, Heterozygous Vangl2 looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair, Disease Models & Mechanisms, Vol:10, ISSN:1754-8403, Pages:409-423
et al., 2016, Association of Forced Vital Capacity with the Developmental Gene NCOR2, PLOS One, Vol:11, ISSN:1932-6203
et al., 2015, Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung, Disease Models & Mechanisms, Vol:8, ISSN:1754-8411, Pages:1531-1542
et al., 2010, The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis, Human Molecular Genetics, Vol:19, ISSN:0964-6906, Pages:2251-2267