41 results found
Yates LL, Dean CH, 2011, Planar polarity: A new player in both lung development and disease., Organogenesis, Vol: 7, Pages: 209-216, ISSN: 1547-6278
The clinical burden of both adult and neonatal lung disease worldwide is substantial; in the UK alone, respiratory disease kills one in four people. It is increasingly recognized that genes and pathways that regulate lung development, may be aberrantly activated in disease and/or reactivated as part of the lungs' intrinsic repair mechanisms. Investigating the genes and signaling pathways that regulate lung growth has led to significant insights into the pathogenesis of congenital and adult lung disease. Recently, the planar cell polarity (PCP) pathway has been shown to be required for normal lung development, and data suggests that this signaling pathway is also involved in the pathogenesis of some lung diseases. In this review, we summarize current evidence indicating that the PCP pathway is required for both lung development and disease.
Yates LL, Papakrivopoulou J, Long DA, et al., 2010, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation, HUMAN MOLECULAR GENETICS, Vol: 19, Pages: 4663-4676, ISSN: 0964-6906
Paudyal A, Damrau C, Patterson VL, et al., 2010, The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear, BMC Developmental Biology, Vol: 10, ISSN: 1471-213X
Yates LL, Schnatwinkel C, Murdoch JN, et al., 2010, The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis, HUMAN MOLECULAR GENETICS, Vol: 19, Pages: 2251-2267, ISSN: 0964-6906
Yates L, McMurray F, Zhang Y, et al., 2009, ENU mutagenesis as a tool for understanding lung development and disease Biochemical Society Transactions 37: 838–842.
Warr N, Siggers P, Bogani D, et al., 2009, Sfrp1 and Sfrp2 are required for normal male sexual development in mice, DEVELOPMENTAL BIOLOGY, Vol: 326, Pages: 273-284, ISSN: 0012-1606
Dean CH, Miller LAD, Smith AN, et al., 2005, Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland, DEVELOPMENTAL BIOLOGY, Vol: 286, Pages: 270-286, ISSN: 0012-1606
Dean C, Ito M, Makarenkova HP, et al., 2004, Bmp7 regulates branching morphogenesis of the lacrimal gland by promoting mesenchymal proliferation and condensation, DEVELOPMENT, Vol: 131, Pages: 4155-4165, ISSN: 0950-1991
Alonso MBD, Zoidl G, Taveggia C, et al., 2004, Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 279, Pages: 25653-25664, ISSN: 0021-9258
Brennan A, Dean CH, Zhang AL, et al., 2000, Endothelins control the timing of Schwann cell generation in vitro and in vivo, DEVELOPMENTAL BIOLOGY, Vol: 227, Pages: 545-557, ISSN: 0012-1606
Dong Z, Dean C, Walters JE, et al., 1997, Response of Schwann cells to mitogens in vitro is determined by pre-exposure to serum, time in vitro, and developmental age., Glia, Vol: 20, Pages: 219-230, ISSN: 0894-1491
We compared the mitogenic response of Schwann cells freshly isolated from adult, neonatal, and embryonic nerves, and compared these cells with cells that had been cultured in serum for 5 days. DNA synthesis in response to growth factors was measured using bromodeoxyuridine and immunocytochemistry. Freshly isolated adult Schwann cells were unresponsive to growth factors with or without forskolin to elevate intracellular cAMP levels. After 5 days of culture in serum, or alternatively in defined medium containing fibroblast growth factor 2 plus forskolin, or neu-differentiation factor beta2, adult cells were responsive to mitogens, whereas cells cultured in defined medium alone remained unresponsive. Serum also increased expression of type 1 fibroblast growth factor receptor. Freshly isolated embryonic and neonatal Schwann cells in contrast responded to growth factors even in the absence of forskolin. This responsiveness changed with time in culture. Neonatal cells cultured for 5 days in defined medium in the presence or absence of serum no longer responded to FGF alone, but required forskolin for a mitogenic response. Thus, the response of freshly isolated cells to mitogens is developmentally regulated; extrinsic signals are required to render adult cells responsive to mitogens; and with time in culture, neonatal cells develop a requirement for cAMP elevation for mitogenic response.
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