Imperial College London

Dr Charlotte Dean

Faculty of MedicineNational Heart & Lung Institute

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 3174c.dean

 
 
//

Location

 

360Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Minelli:2016:10.1371/journal.pone.0147388,
author = {Minelli, C and Dean, CH and Hind, M and Couto, Alves A and Amaral, AFS and Siroux, V and Huikari, V and Soler, Artigas M and Evans, DM and Loth, DW and Bossé, Y and Postma, DS and Sin, D and Thompson, J and Demenais, F and Henderson, J and Bouzigon, E and Jarvis, D and Jarvelin, M and Burney, P and Minelli, C},
doi = {10.1371/journal.pone.0147388},
journal = {PLOS One},
title = {Association of Forced Vital Capacity with the Developmental Gene NCOR2},
url = {http://dx.doi.org/10.1371/journal.pone.0147388},
volume = {11},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundForced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absenceof chronic respiratory conditions. Epidemiological evidence highlights the role of early lifefactors on adult FVC, pointing to environmental exposures and genes affecting lung developmentas risk factors for low FVC later in life. Although highly heritable, a small number ofgenes have been found associated with FVC, and we aimed at identifying further geneticvariants by focusing on lung development genes.PLOS ONE | DOI:10.1371/journal.pone.0147388 February 2, 2016 1 / 17OPEN ACCESSCitation: Minelli C, Dean CH, Hind M, Alves AC,Amaral AFS, Siroux V, et al. (2016) Association ofForced Vital Capacity with the Developmental GeneNCOR2. PLoS ONE 11(2): e0147388. doi:10.1371/journal.pone.0147388Editor: Philipp Latzin, University Children's HospitalBasel, SWITZERLANDReceived: August 28, 2015Accepted: January 4, 2016Published: February 2, 2016Copyright: © 2016 Minelli et al. This is an openaccess article distributed under the terms of theCreative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.Data Availability Statement: All relevant data arewithin the paper and its Supporting Information files.Funding: The authors have no support or funding toreport.Competing Interests: The authors have declaredthat no competing interests exist.MethodsPer-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP forthe top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and5,062 children (ALSPAC). Associations were considered replicated if the replication p-valuesurvived Bonferroni correction (p<0.002; 0.05/25), with a nominal p-value considered assuggestive evidence. For SNPs with evidence of replication, effects on the expression levelsof n
AU - Minelli,C
AU - Dean,CH
AU - Hind,M
AU - Couto,Alves A
AU - Amaral,AFS
AU - Siroux,V
AU - Huikari,V
AU - Soler,Artigas M
AU - Evans,DM
AU - Loth,DW
AU - Bossé,Y
AU - Postma,DS
AU - Sin,D
AU - Thompson,J
AU - Demenais,F
AU - Henderson,J
AU - Bouzigon,E
AU - Jarvis,D
AU - Jarvelin,M
AU - Burney,P
AU - Minelli,C
DO - 10.1371/journal.pone.0147388
PY - 2016///
SN - 1932-6203
TI - Association of Forced Vital Capacity with the Developmental Gene NCOR2
T2 - PLOS One
UR - http://dx.doi.org/10.1371/journal.pone.0147388
UR - http://hdl.handle.net/10044/1/28988
VL - 11
ER -